Kmt2a (Mus musculus)
CxxC

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSMUSG00000002028 T168117_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA binding activity; chromatin binding activity; and histone methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
KMT2A
M01912_2.00 		Homo sapiens
NHNCGNBNNN
NNNVNCGNDN		 PBM
Weirauch et al.(2014)
pTH7031 		0.979 0.979
kmt2a
M01921_2.00 		Xenopus tropicalis
NNNNNDCGNN
NNCGHNNNNN		 PBM
Weirauch et al.(2014)
pTH8559 		0.979 0.979
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000002095 CxxC 1144 1191
ENSMUSP00000110337 CxxC 1144 1191
ENSMUSP00000122541 CxxC 1177 1224
ENSMUSP00000138767 CxxC 356 403

Links

Other CxxC family TFs
Other Mus musculus TFs

Invalid Input OrderBy

74 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action