Kmt2a (Rattus norvegicus)
CxxC

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02008 (zf-CXXC) IPR002857 ENSRNOG00000015133 T168290_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable several functions, including lysine-acetylated histone binding activity; protein homodimerization activity; and protein methyltransferase activity. Involved in membrane depolarization and response to potassium ion. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of MLL1 complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
KMT2A
M01912_2.00 		Homo sapiens
NHNCGNBNNN
NNNVNCGNDN		 PBM
Weirauch et al.(2014)
pTH7031 		1.000 1.000
kmt2a
M01921_2.00 		Xenopus tropicalis
NNNNNDCGNN
NNCGHNNNNN		 PBM
Weirauch et al.(2014)
pTH8559 		0.958 0.958
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000020573 CxxC 1002 1049

Links

Other CxxC family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

73 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action