MCINX010888 (Melitaea cinxia)
Ets

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00178 (Ets) IPR000418 MCINX010888 T177455_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Ets98B
M03727_2.00
Drosophila melanogaster
TAMCGGATGCN

NGCATCCGKTA
SELEX
Nitta et al.(2015)
Ets98B_1
0.968 0.865
Ets98B
M03728_2.00
Drosophila melanogaster
TKGCGGATGCN

NGCATCCGCMA
SELEX
Nitta et al.(2015)
Ets98B_2
0.968 0.865
Ets98B
M03729_2.00
Drosophila melanogaster
ATGATCCGGGACN

NGTCCCGGATCAT
SELEX
Nitta et al.(2015)
Ets98B_3
0.968 0.865
Ets98B
M03730_2.00
Drosophila melanogaster
GSATMCGKTA

TAMCGKATSC
SELEX
Nitta et al.(2015)
Ets98B_4
0.968 0.865
Ets98B
M03731_2.00
Drosophila melanogaster
ATGATCCGGGASN

NSTCCCGGATCAT
SELEX
Nitta et al.(2015)
Ets98B_5
0.968 0.865
Ets98B
M06191_2.00
Drosophila melanogaster
ASCCGGAWC

GWTCCGGST
B1H
Zhu et al.(2011)
Ets98B_SANGER_10_FBgn0005659
0.968 0.865
Spdef
M00159_2.00
Mus musculus
NNVMGGAHNN

NNDTCCKBNN
PBM
Badis et al.(2009)
Spdef_0905
0.940 0.743
Spdef
M01488_2.00
Mus musculus
NDNVMGGAHN

NDTCCKBNHN
PBM
Wei et al.(2010)
Spdef
0.940 0.743
SPDEF
M02973_2.00
Homo sapiens
AMCCGGATRTD

HAYATCCGGKT
SELEX
Jolma et al.(2013)
SPDEF_1
0.940 0.743
SPDEF
M02974_2.00
Homo sapiens
ATRATCCGGGAMMHY

RDKKTCCCGGATYAT
SELEX
Jolma et al.(2013)
SPDEF_2
0.940 0.743
SPDEF
M02975_2.00
Homo sapiens
RCAGDAAGAAGTAWWM

KWWTACTTCTTHCTGY
SELEX
Jolma et al.(2013)
SPDEF_3
0.940 0.743
SPDEF
M02976_2.00
Homo sapiens
AMCCGGATRTD

HAYATCCGGKT
SELEX
Jolma et al.(2013)
SPDEF_4
0.940 0.743
SPDEF
M02977_2.00
Homo sapiens
WTRATCCGGGACCMC

GKGGTCCCGGATYAW
SELEX
Jolma et al.(2013)
SPDEF_5
0.940 0.743
SPDEF
M02978_2.00
Homo sapiens
RCAGDAAGAMGTAWHM

KDWTACKTCTTHCTGY
SELEX
Jolma et al.(2013)
SPDEF_6
0.940 0.743
SPDEF
M04748_2.00
Homo sapiens
NWVCCGGATRYN

NRYATCCGGBWN
SELEX
Yin et al.(2017)
SPDEF_eDBD_HT-SELEX
0.940 0.743
SPDEF
M04750_2.00
Homo sapiens
NWVCCGGATRYN

NRYATCCGGBWN
SELEX
Yin et al.(2017)
SPDEF_FL_HT-SELEX
0.940 0.743
SPDEF
M09530_2.00
Homo sapiens
WVCMGGAWVY

RBWTCCKGBW
Misc
Heinz et al.(2010)
VCaP-SPDEF_SRA014231
0.940 0.743
SPDEF
M04749_2.00
Homo sapiens
NAVCMGGATRYD

HRYATCCKGBTN
SELEX
Yin et al.(2017)
SPDEF_eDBD_Methyl-HT-SELEX
0.940 0.743
SPDEF
M04751_2.00
Homo sapiens
NAVCMGKATRYD

HRYATMCKGBTN
SELEX
Yin et al.(2017)
SPDEF_FL_Methyl-HT-SELEX
0.940 0.743
Ets96B
M03733_2.00
Drosophila melanogaster
DCCGKAAGYN

NRCTTMCGGH
SELEX
Nitta et al.(2015)
Ets96B_1
0.721 0.554
Ets96B
M06193_2.00
Drosophila melanogaster
RCCGGAAGYVV

BBRCTTCCGGY
B1H
Zhu et al.(2011)
Ets96B_SANGER_5_FBgn0039225
0.721 0.554
For this family, TFs with SR scores > 0.717 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
MCINX010888-PA Ets 393 467

Links

Other Ets family TFs
Other Melitaea cinxia TFs

246 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
KGM_21536 Danaus plexippus KGM_21536 I 0.990
BGIBMGA001296 Bombyx mori BGIBMGA001296 I 0.990
GB50829 Apis mellifera GB50829 I 0.987
Cflo_02996--XP_396511.3_APIME Camponotus floridanus Cflo_02996--XP_396511.3_APIME I 0.987
ACEP13202 Atta cephalotes ACEP13202 I 0.987
Hsal_06802--XP_396511.3_APIME Harpegnathos saltator Hsal_06802--XP_396511.3_APIME I 0.987
NV12052 Nasonia vitripennis NV12052 I 0.987
DAPPUDRAFT_8447 Daphnia pulex DAPPUDRAFT_8447 I 0.985
ISCW005284 Ixodes scapularis ISCW005284 I 0.985
PHUM503640 Pediculus humanus PHUM503640 I 0.985
LLOJ008642 Lutzomyia longipalpis LLOJ008642 I 0.984
SMAR015178 Strigamia maritima SMAR015178 I 0.983
PPAI004682 Phlebotomus papatasi PPAI004682 I 0.981
CLEC002637 Cimex lectularius CLEC002637 I 0.979
AATE008235 Anopheles atroparvus AATE008235 I 0.977
TC008243 Tribolium castaneum TC008243 I 0.976
RPRC004402 Rhodnius prolixus RPRC004402 I 0.976
ACUA005433 Anopheles culicifacies ACUA005433 I 0.973
ACOM037974 Anopheles coluzzii ACOM037974 I 0.973
ADIR002130 Anopheles dirus ADIR002130 I 0.973
tetur10g01220 Tetranychus urticae tetur10g01220 I 0.973
AARA006222 Anopheles arabiensis AARA006222 I 0.973
AALB004027 Anopheles albimanus AALB004027 I 0.973
AEPI002241 Anopheles epiroticus AEPI002241 I 0.973
AMIN004239 Anopheles minimus AMIN004239 I 0.973
AMEC015581 Anopheles melas AMEC015581 I 0.973
AQUA002229 Anopheles quadriannulatus AQUA002229 I 0.973
AGAP011341 Anopheles gambiae AGAP011341 I 0.973
ASTEI04247 Anopheles stephensi ASTEI04247 I 0.973
ASIS007112 Anopheles sinensis ASIS007112 I 0.973
AMAM008021 Anopheles maculatus AMAM008021 I 0.973
AMEM008533 Anopheles merus AMEM008533 I 0.973
AFAF002698 Anopheles farauti AFAF002698 I 0.973
AFUN007103 Anopheles funestus AFUN007103 I 0.973
YQE_03066 Dendroctonus ponderosae YQE_03066 I 0.972
AAEL005147 Aedes aegypti AAEL005147 I 0.971
GM16357 Drosophila sechellia FBgn0171272 I 0.968
GE23760 Drosophila yakuba FBgn0240917 I 0.968
GD21351 Drosophila simulans FBgn0192788 I 0.968
Ets98B Drosophila melanogaster FBgn0005659 D 0.968
GH16564 Drosophila grimshawi FBgn0124035 I 0.968
GG11574 Drosophila erecta FBgn0103871 I 0.968
CapteG171657 Capitella teleta CapteG171657 I 0.967
LCUP001713 Lucilia cuprina LCUP001713 I 0.967
MDOA013732 Musca domestica MDOA013732 I 0.967
GJ10475 Drosophila virilis FBgn0197755 I 0.962
GL13714 Drosophila persimilis FBgn0151319 I 0.962
GA27000 Drosophila pseudoobscura FBgn0248371 I 0.962
GF16302 Drosophila ananassae FBgn0093324 I 0.962
GI22028 Drosophila mojavensis FBgn0144757 I 0.962
Ocbimv22034220m.g Octopus bimaculoides Ocbimv22034220m.g I 0.957
GK11770 Drosophila willistoni FBgn0213781 I 0.955
HelroG127646 Helobdella robusta HelroG127646 I 0.952
Afo_R002084 Aptenodytes forsteri Afo_R002084 I 0.950
Sakowv30001869m.g Saccoglossus kowalevskii Sakowv30001869m.g I 0.949
LotgiG140186 Lottia gigantea LotgiG140186 I 0.946
CGI_10015192 Crassostrea gigas CGI_10015192 I 0.945
BGLB000499 Biomphalaria glabrata BGLB000499 I 0.944
ENSPSIG00000004860 Pelodiscus sinensis ENSPSIG00000004860 I 0.940
SPDEF Pan troglodytes ENSPTRG00000018065 I 0.940
Spdef Rattus norvegicus ENSRNOG00000000491 I 0.940
SPDEF Pteropus vampyrus ENSPVAG00000015594 I 0.940
ENSSHAG00000004899 Sarcophilus harrisii ENSSHAG00000004899 I 0.940
Aan_R003780 Calypte anna Aan_R003780 I 0.940
SPDEF Taeniopygia guttata ENSTGUG00000001781 I 0.940
SPDEF Tursiops truncatus ENSTTRG00000007816 I 0.940
ENSSTOG00000028807 Ictidomys tridecemlineatus ENSSTOG00000028807 I 0.940
ENSSARG00000011301 Sorex araneus ENSSARG00000011301 I 0.940
SPDEF Microcebus murinus ENSMICG00000013437 I 0.940
SPDEF Gallus gallus ENSGALG00000002792 I 0.940
SPDEF Homo sapiens ENSG00000124664 D 0.940
SPDEF Felis catus ENSFCAG00000015357 I 0.940
SPDEF Gorilla gorilla ENSGGOG00000000383 I 0.940
fgenesh2_pg.scaffold_297000075 Branchiostoma floridae fgenesh2_pg.scaffold_297000075 I 0.940
ENSLACG00000017022 Latimeria chalumnae ENSLACG00000017022 I 0.940
Pvit_06029 Pogona vitticeps Pvit_06029 I 0.940
ENSFALG00000003770 Ficedula albicollis ENSFALG00000003770 I 0.940
SPDEF Echinops telfairi ENSETEG00000005883 I 0.940
SPDEF Canis familiaris ENSCAFG00000001227 I 0.940
SPDEF Bos taurus ENSBTAG00000021993 I 0.940
SPDEF Anolis carolinensis ENSACAG00000015770 I 0.940
SPDEF Callithrix jacchus ENSCJAG00000015294 I 0.940
ENSCSAG00000009798 Chlorocebus sabaeus ENSCSAG00000009798 I 0.940
spdef Xenopus tropicalis XB-GENE-491205 I 0.940
Spdef Dipodomys ordii ENSDORG00000016134 I 0.940
SPDEF Loxodonta africana ENSLAFG00000002253 I 0.940
ENSLOCG00000009979 Lepisosteus oculatus ENSLOCG00000009979 I 0.940
SPDEF Otolemur garnettii ENSOGAG00000011260 I 0.940
ENSP00000363149 Macaca fascicularis ENSP00000363149 I 0.940
ENSP00000363149-D1 Bos grunniens ENSP00000363149-D1 I 0.940
Cmyd_10011181 Chelonia mydas Cmyd_10011181 I 0.940
ENSPANG00000016482 Papio anubis ENSPANG00000016482 I 0.940
Alligator_sinensis_CCG020447.1 Alligator sinensis Alligator_sinensis_CCG020447.1 I 0.940
Myotis_brandtii_SPDEF_10017789 Myotis brandtii Myotis_brandtii_SPDEF_10017789 I 0.940
ENSNLEG00000008374 Nomascus leucogenys ENSNLEG00000008374 I 0.940
ENSMMUG00000007812 Macaca mulatta ENSMMUG00000007812 I 0.940
SPDEF Myotis lucifugus ENSMLUG00000025914 I 0.940
Ogr09009 Ophisaurus gracilis Ogr09009 I 0.940
SPDEF Monodelphis domestica ENSMODG00000013916 I 0.940
ENSMPUG00000003167 Mustela putorius furo ENSMPUG00000003167 I 0.940
ENSPPYG00000016518 Pongo abelii ENSPPYG00000016518 I 0.940
Spdef Mus musculus ENSMUSG00000024215 D 0.940
ENSSSCG00000024531 Sus scrofa ENSSSCG00000024531 I 0.939
SPU_008528 Strongylocentrotus purpuratus SPU_008528 I 0.938
ENSCING00000003158 Ciona intestinalis ENSCING00000003158 I 0.937
CGI_10015191 Crassostrea gigas CGI_10015191 I 0.936
e_gw.6.372.1 Branchiostoma floridae e_gw.6.372.1 I 0.933
ENSONIG00000014752 Oreochromis niloticus ENSONIG00000014752 I 0.932
SPDEF Ochotona princeps ENSOPRG00000009328 I 0.932
ENSPFOG00000015137 Poecilia formosa ENSPFOG00000015137 I 0.932
SPDEF Tetraodon nigroviridis ENSTNIG00000018309 I 0.932
ENSGACG00000004912 Gasterosteus aculeatus ENSGACG00000004912 I 0.932
SPDEF Cavia porcellus ENSCPOG00000020697 I 0.932
ENSAMXG00000016751 Astyanax mexicanus ENSAMXG00000016751 I 0.932
SPDEF Equus caballus ENSECAG00000021717 I 0.932
SPDEF Takifugu rubripes ENSTRUG00000001430 I 0.932
ENSGMOG00000000105 Gadus morhua ENSGMOG00000000105 I 0.932
SPDEF Ornithorhynchus anatinus ENSOANG00000008044 I 0.931
ENSAMEG00000000981 Ailuropoda melanoleuca ENSAMEG00000000981 I 0.928
SPDEF Takifugu rubripes ENSTRUG00000011048 I 0.925
SPDEF Tetraodon nigroviridis ENSTNIG00000001703 I 0.925
SNAPOd2T00009984001 Oikopleura dioica SNAPOd2T00009984001 I 0.920
ENSMGAG00000002725 Meleagris gallopavo ENSMGAG00000002725 I 0.914
CGOC_0000920101 Cylicostephanus goldi CGOC_0000920101 I 0.907
SVUK_0000082401 Strongylus vulgaris SVUK_0000082401 I 0.907
DICVIV_08502 Dictyocaulus viviparus DICVIV_08502 I 0.907
HCOI01123400 Haemonchus contortus HCOI01123400 I 0.907
NECAME_17353 Necator americanus NECAME_17353 I 0.907
ENSORLG00000007287 Oryzias latipes ENSORLG00000007287 I 0.904
ENSGACG00000003298 Gasterosteus aculeatus ENSGACG00000003298 I 0.894
ENSOARG00000010751 Ovis aries ENSOARG00000010751 I 0.894
fgenesh2_pg.scaffold_113000046 Branchiostoma floridae fgenesh2_pg.scaffold_113000046 I 0.886
ENSVPAG00000011404 Vicugna pacos ENSVPAG00000011404 I 0.886
ENSGMOG00000010043 Gadus morhua ENSGMOG00000010043 I 0.864
ACAC_0000355601 Angiostrongylus cantonensis ACAC_0000355601 I 0.863
OESDEN_05539 Oesophagostomum dentatum OESDEN_05539 I 0.863
HCOI00762500 Haemonchus contortus HCOI00762500 I 0.863
ANCCAN_05238 Ancylostoma caninum ANCCAN_05238 I 0.863
ANCCEY_07824 Ancylostoma ceylanicum ANCCEY_07824 I 0.863
ANCDUO_13439 Ancylostoma duodenale ANCDUO_13439 I 0.863
SPDEF Oryctolagus cuniculus ENSOCUG00000009812 I 0.862
L893_g26809 Steinernema glaseri L893_g26809 I 0.850
WUBG_02585 Wuchereria bancrofti WUBG_02585 I 0.850
L898_g2231 Steinernema monticolum L898_g2231 I 0.850
nAv.1.0.1.g03172 Acanthocheilonema viteae nAv.1.0.1.g03172 I 0.850
Bm3502 Brugia malayi Bm3502 I 0.850
L892_g3915 Steinernema scapterisci L892_g3915 I 0.850
GPUH_0000363301 Gongylonema pulchrum GPUH_0000363301 I 0.850
nAv.1.0.1.g05129 Acanthocheilonema viteae nAv.1.0.1.g05129 I 0.850
ASU_11081 Ascaris suum ASU_11081 I 0.850
EEL_0000969001 Elaeophora elaphi EEL_0000969001 I 0.850
EVEC_0001170101 Enterobius vermicularis EVEC_0001170101 I 0.850
L596_g5779 Steinernema carpocapsae L596_g5779 I 0.850
BTMF_0001332301 Brugia timori BTMF_0001332301 I 0.850
L889_g30192 Steinernema feltiae L889_g30192 I 0.850
nAv.1.0.1.g05865 Acanthocheilonema viteae nAv.1.0.1.g05865 I 0.850
SPAL_0001077000 Strongyloides papillosus SPAL_0001077000 I 0.850
PTRK_0001608800 Parastrongyloides trichosuri PTRK_0001608800 I 0.850
OFLC_0001252601 Onchocerca flexuosa OFLC_0001252601 I 0.850
LOAG_13336 Loa loa LOAG_13336 I 0.850
SVE_1980500 Strongyloides venezuelensis SVE_1980500 I 0.850
WBGene00242060 Onchocerca volvulus WBGene00242060 I 0.850
TCNE_0000935601 Toxocara canis TCNE_0000935601 I 0.850
TCLT_0000444401 Thelazia callipaeda TCLT_0000444401 I 0.850
nOo.2.0.1.g02415 Onchocerca ochengi nOo.2.0.1.g02415 I 0.850
SSTP_0001090100 Strongyloides stercoralis SSTP_0001090100 I 0.850
nLs.2.1.2.g03354 Litomosoides sigmodontis nLs.2.1.2.g03354 I 0.850
nDi.2.2.2.g02599 Dirofilaria immitis nDi.2.2.2.g02599 I 0.850
DME_0000328201 Dracunculus medinensis DME_0000328201 I 0.849
RSKR_0000577300 Rhabditophanes kr3021 RSKR_0000577300 I 0.838
PXEA_0001691201 Protopolystoma xenopodis PXEA_0001691201 I 0.834
BXY_0473000 Bursaphelenchus xylophilus BXY_0473000 I 0.834
Ppa-ets-4 Pristionchus pacificus PPA05668 I 0.830
Brh_R004752 Buceros rhinoceros Brh_R004752 I 0.822
ets-4 Caenorhabditis elegans WBGene00017687 I 0.817
CBN23969 Caenorhabditis brenneri CBN23969 I 0.817
CBG10834 Caenorhabditis briggsae CBG10834 I 0.817
TTAC_0000221001 Hydatigera taeniaeformis TTAC_0000221001 I 0.801
CRE00614 Caenorhabditis remanei CRE00614 I 0.801
ENSGMOG00000002811 Gadus morhua ENSGMOG00000002811 I 0.787
MhA1_Contig367.frz3.gene4 Meloidogyne hapla MhA1_Contig367.frz3.gene4 I 0.782
Minc17377 Meloidogyne incognita Minc17377 I 0.782
Minc12522 Meloidogyne incognita Minc12522 I 0.782
genemark-nMf.1.1.scaf01112-processed-gene-0.4 Meloidogyne floridensis genemark-nMf.1.1.scaf01112-processed-gene-0.4 I 0.782
XP_002153910.1 Hydra magnipapillata XP_002153910.1 I 0.769
ETV1 Erinaceus europaeus ENSEEUG00000002018 I 0.769
ENSDORG00000008580 Dipodomys ordii ENSDORG00000008580 I 0.769
ETV1 Ochotona princeps ENSOPRG00000003861 I 0.769
TMUE_s0025002400 Trichuris muris TMUE_s0025002400 I 0.759
D918_08596 Trichuris suis D918_08596 I 0.759
AAEL010488 Aedes aegypti AAEL010488 I 0.758
ASTEI09980 Anopheles stephensi ASTEI09980 I 0.758
AMEC001201 Anopheles melas AMEC001201 I 0.758
AMAM021336 Anopheles maculatus AMAM021336 I 0.758
ACUA014807 Anopheles culicifacies ACUA014807 I 0.758
AMEC018562 Anopheles melas AMEC018562 I 0.758
ADIR006115 Anopheles dirus ADIR006115 I 0.758
CPIJ014720 Culex quinquefasciatus CPIJ014720 I 0.758
AFAF014053 Anopheles farauti AFAF014053 I 0.758
AFUN003294 Anopheles funestus AFUN003294 I 0.758
AMEM005008 Anopheles merus AMEM005008 I 0.758
AMIN001779 Anopheles minimus AMIN001779 I 0.758
AATE014059 Anopheles atroparvus AATE014059 I 0.758
AARA000252 Anopheles arabiensis AARA000252 I 0.758
CpipJ_CPIJ014720 Culex pipiens CpipJ_CPIJ014720 I 0.758
AGAP009350 Anopheles gambiae AGAP009350 I 0.758
ACHR002069 Anopheles christyi ACHR002069 I 0.758
ACUA006469 Anopheles culicifacies ACUA006469 I 0.758
AQUA003328 Anopheles quadriannulatus AQUA003328 I 0.758
AEPI002395 Anopheles epiroticus AEPI002395 I 0.758
L889_g5244 Steinernema feltiae L889_g5244 I 0.751
ENSCSAG00000003449 Chlorocebus sabaeus ENSCSAG00000003449 I 0.746
TTRE_0000457801 Trichuris trichiura TTRE_0000457801 I 0.737
SMU15002081 Schmidtea mediterranea SMU15002081 I 0.731
ADAC010205 Anopheles darlingi ADAC010205 I 0.730
AALB000421 Anopheles albimanus AALB000421 I 0.730
NEMVEDRAFT_v1g16815 Nematostella vectensis NEMVEDRAFT_v1g16815 I 0.730
CLEC003449 Cimex lectularius CLEC003449 I 0.729
RPRC011718 Rhodnius prolixus RPRC011718 I 0.729
HHAL010647-PA Halyomorpha halys HHAL010647-PA I 0.729
LDEC012729 Leptinotarsa decemlineata LDEC012729 I 0.729
NECAME_08455 Necator americanus NECAME_08455 I 0.729
PPAI000920 Phlebotomus papatasi PPAI000920 I 0.729
SNAPOd2T00019016001 Oikopleura dioica SNAPOd2T00019016001 I 0.727
Minc06986 Meloidogyne incognita Minc06986 I 0.723
Ets96B Drosophila melanogaster FBgn0039225 D 0.721
GG11319 Drosophila erecta FBgn0103620 I 0.721
GH19112 Drosophila grimshawi FBgn0126579 I 0.721
GF23047 Drosophila ananassae FBgn0100041 I 0.721
ACYPI52048 Acyrthosiphon pisum ACYPI52048 I 0.721
GJ23541 Drosophila virilis FBgn0210638 I 0.721
GI23566 Drosophila mojavensis FBgn0146292 I 0.721
GE23515 Drosophila yakuba FBgn0240694 I 0.721
GA19934 Drosophila pseudoobscura FBgn0079930 I 0.721
CLEC004830 Cimex lectularius CLEC004830 I 0.721
GM26627 Drosophila sechellia FBgn0181480 I 0.721
GK14107 Drosophila willistoni FBgn0216113 I 0.721
MDOA002896 Musca domestica MDOA002896 I 0.721
GL13628 Drosophila persimilis FBgn0151233 I 0.721
LCUP000690 Lucilia cuprina LCUP000690 I 0.721
GD21130 Drosophila simulans FBgn0192582 I 0.721
CapteG46009 Capitella teleta CapteG46009 I 0.721
HHAL009028-PA Halyomorpha halys HHAL009028-PA I 0.721
ISCW002717 Ixodes scapularis ISCW002717 I 0.720
ACYPI34471 Acyrthosiphon pisum ACYPI34471 I 0.719
ENSGACG00000008646 Gasterosteus aculeatus ENSGACG00000008646 I 0.718