|
|
Foxn1
(Mus musculus)
Forkhead
|
TF Information |
|---|
| Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
| PF00250 (Forkhead) |
IPR001766 |
ENSMUSG00000002057 |
T186341_2.00 |
Ensembl (2018-Dec-8) |
Link out |
| NCBI Gene Info:The protein encoded by this gene is part of the forkhead family or "winged-helix" transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013] |
Directly determined binding motifs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
Foxn1
M01010_2.00 |
Mus musculus |
NAHRCNNNNN |
NNNNNGYDTN |
PBM
Nakagawa et al.(2013)
Foxn1 |
(Direct) |
(Direct) |
Motifs from related TFs |
|---|
| Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR
Score |
DBD
Identity |
FOXN1
M10531_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$WHN_B
|
0.849
|
0.988
|
Foxn4
M01011_2.00 |
Mus musculus |
NNNVACGCNN |
NNGCGTBNNN |
PBM
Nakagawa et al.(2013)
Foxn4
|
0.798
|
0.884
|
jumu
M01012_2.00 |
Drosophila melanogaster |
NNNNVACGCN |
NGCGTBNNNN |
PBM
Nakagawa et al.(2013)
Jumeau
|
0.734
|
0.698
|
| For this family, TFs with SR scores > 0.664 will likely have a similar motif |