grh-1 (Caenorhabditis elegans)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 WBGene00001707 T199479_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables sequence-specific DNA binding activity. Involved in aging. Located in nucleus. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to several human genes including GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
Y48G8AR.1a Grainyhead 166 387
Y48G8AR.1b Grainyhead 166 387

Links

Other Grainyhead family TFs
Other Caenorhabditis elegans TFs

40 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
NBR_0001111401 Nippostrongylus brasiliensis NBR_0001111401 I 0.923
CBG08484 Caenorhabditis briggsae CBG08484 N 0.919
CBN22200 Caenorhabditis brenneri CBN22200 N 0.914
CRE28107 Caenorhabditis remanei CRE28107 N 0.905
ACAC_0000008501 Angiostrongylus cantonensis ACAC_0000008501 N 0.838
ANCCAN_14716 Ancylostoma caninum ANCCAN_14716 N 0.832
DICVIV_02142 Dictyocaulus viviparus DICVIV_02142 N 0.823
MhA1_Contig3342.frz3.fgene1 Meloidogyne hapla MhA1_Contig3342.frz3.fgene1 I 0.819
NECAME_01451 Necator americanus NECAME_01451 N 0.815
ACOC_0000493901 Angiostrongylus costaricensis ACOC_0000493901 N 0.814
TELCIR_08176 Teladorsagia circumcincta TELCIR_08176 N 0.811
HPLM_0001248301 Haemonchus placei HPLM_0001248301 N 0.811
GPUH_0000076201 Gongylonema pulchrum GPUH_0000076201 N 0.809
ANCCEY_13935 Ancylostoma ceylanicum ANCCEY_13935 N 0.791
WBGene00238278 Onchocerca volvulus WBGene00238278 N 0.791
ALUE_0000347301 Ascaris lumbricoides ALUE_0000347301 N 0.787
ASU_10686 Ascaris suum ASU_10686 N 0.787
nAv.1.0.1.g04294 Acanthocheilonema viteae nAv.1.0.1.g04294 N 0.786
TCNE_0000897001 Toxocara canis TCNE_0000897001 N 0.786
ASIM_0001085501 Anisakis simplex ASIM_0001085501 N 0.786
nOo.2.0.1.g11935 Onchocerca ochengi nOo.2.0.1.g11935 N 0.776
nLs.2.1.2.g09328 Litomosoides sigmodontis nLs.2.1.2.g09328 N 0.773
OESDEN_24323 Oesophagostomum dentatum OESDEN_24323 N 0.771
CJA15586 Caenorhabditis japonica CJA15586 N 0.769
SMUV_0000990001 Syphacia muris SMUV_0000990001 N 0.766
nDi.2.2.2.g12300 Dirofilaria immitis nDi.2.2.2.g12300 I 0.764
PTRK_0001384100 Parastrongyloides trichosuri PTRK_0001384100 N 0.749
ANCDUO_02893 Ancylostoma duodenale ANCDUO_02893 N 0.748
DME_0000295201 Dracunculus medinensis DME_0000295201 N 0.744
LOAG_15534 Loa loa LOAG_15534 N 0.740
SSTP_0000594700 Strongyloides stercoralis SSTP_0000594700 N 0.735
SPAL_0001441800 Strongyloides papillosus SPAL_0001441800 N 0.731
Bm6679 Brugia malayi Bm6679 N 0.714
nOo.2.0.1.g10313 Onchocerca ochengi nOo.2.0.1.g10313 N 0.713
nOo.2.0.1.g10305 Onchocerca ochengi nOo.2.0.1.g10305 N 0.713
EEL_0000257001 Elaeophora elaphi EEL_0000257001 N 0.711
nDi.2.2.2.g12190 Dirofilaria immitis nDi.2.2.2.g12190 N 0.711
HCOI00042900 Haemonchus contortus HCOI00042900 N 0.711
BXY_1053400 Bursaphelenchus xylophilus BXY_1053400 N 0.700