CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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IRX5
(
Homo sapiens
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSG00000176842
T209912_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
IRX5
M03222_2.00
Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN
SELEX
Jolma et al.(2013)
IRX5_1
(Direct)
(Direct)
IRX5
M05315_2.00
Homo sapiens
NBDTGTHNDACAYVN
NBRTGTHNDACAHVN
SELEX
Yin et al.(2017)
IRX5_eDBD_HT-SELEX
(Direct)
(Direct)
IRX5
M05316_2.00
Homo sapiens
WYRYGHHNHAYRYRY
RYRYRTDNDDCRYRW
SELEX
Yin et al.(2017)
IRX5_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Irx2
M00386_2.00
Mus musculus
NNDACAHNN
NNDTGTHNN
PBM
Berger et al.(2008)
Irx2_0900
0.867
1.000
Irx5
M00455_2.00
Mus musculus
NNNDACAHN
NDTGTHNNN
PBM
Berger et al.(2008)
Irx5_2385
0.867
1.000
IRX2
M03212_2.00
Homo sapiens
NDACAYRACAHN
NDTGTYRTGTHN
SELEX
Jolma et al.(2013)
IRX2_1
0.867
1.000
ara
M06518_2.00
Drosophila melanogaster
WWACA
TGTWW
B1H
Mathelier et al.(2014)
MA0210.1
0.815
0.930
ara
M06313_2.00
Drosophila melanogaster
TGTWWWNN
NNWWWACA
B1H
Zhu et al.(2011)
Ara_Cell_FBgn0015904
0.815
0.930
ara
M06314_2.00
Drosophila melanogaster
DWWACA
TGTWWH
B1H
Zhu et al.(2011)
Ara_SOLEXA_FBgn0015904
0.815
0.930
caup
M06519_2.00
Drosophila melanogaster
WAACA
TGTTW
B1H
Mathelier et al.(2014)
MA0217.1
0.806
0.877
caup
M06315_2.00
Drosophila melanogaster
HWDWAACA
TGTTWHWD
B1H
Zhu et al.(2011)
Caup_Cell_FBgn0015919
0.806
0.877
caup
M06316_2.00
Drosophila melanogaster
NDDACA
TGTHHN
B1H
Zhu et al.(2011)
Caup_SOLEXA_FBgn0015919
0.806
0.877
Irx4
M00416_2.00
Mus musculus
NNNDAMAH
DTKTHNNN
PBM
Berger et al.(2008)
Irx4_2242
0.780
0.877
Irx6
M00456_2.00
Mus musculus
NNDAHWN
NWDTHNN
PBM
Berger et al.(2008)
Irx6_2623
0.780
0.860
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000316250
Homeodomain
114
173
PAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
ENSP00000378132
Homeodomain
114
173
PAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
ENSP00000453725
Homeodomain
48
107
PAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKK
Links
Other
Homeodomain
family TFs
Other
Homo sapiens
TFs
388 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy