CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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TOS8
(
Saccharomyces cerevisiae
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
YGL096W
T224761_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables chromatin binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin. Human ortholog(s) of this gene implicated in cleft palate, cardiac defects, and intellectual disabillity. Orthologous to several human genes including PKNOX1 (PBX/knotted 1 homeobox 1) and PKNOX2 (PBX/knotted 1 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TOS8
M00057_2.00
Saccharomyces cerevisiae
NNNCRYGNNN
NNNCRYGNNN
PBM
Badis et al.(2008)
TOS8_2100
(Direct)
(Direct)
TOS8
M02192_2.00
Saccharomyces cerevisiae
NNNTKACGTMW
WKACGTMANNN
PBM
Weirauch et al.(2014)
pTH5696
(Direct)
(Direct)
TOS8
M07486_2.00
Saccharomyces cerevisiae
NWTGACAB
VTGTCAWN
PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0408.1
(Direct)
(Direct)
TOS8
M08574_2.00
Saccharomyces cerevisiae
NWTGACAB
VTGTCAWN
Misc
DeBoer et al.(2011)
YGL096W_494
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
CUP9
M00059_2.00
Saccharomyces cerevisiae
TGACABHW
WDVTGTCA
PBM
Badis et al.(2008)
CUP9_4508
0.804
0.800
CUP9
M01553_2.00
Saccharomyces cerevisiae
NWGACAYWWH
DWWRTGTCWN
PBM
Zhu et al.(2009)
Cup9
0.804
0.800
CUP9
M07488_2.00
Saccharomyces cerevisiae
TGACAYAWW
WWTRTGTCA
PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0288.1
0.804
0.800
CUP9
M08576_2.00
Saccharomyces cerevisiae
TGACAYAWW
WWTRTGTCA
Misc
DeBoer et al.(2011)
YPL177C_480
0.804
0.800
CAGL0H02959g
M02060_2.00
Candida glabrata
NDTDACRBNN
NNVYGTHAHN
PBM
Weirauch et al.(2014)
pTH6455
0.640
0.745
For this family, TFs with SR scores >
0.599
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00057_2.00
Homeodomain
51
108
HGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRRK
M02192_2.00
Homeodomain
1
58
HGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRRK
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
YGL096W
Homeodomain
195
252
HGKRSNLPKATVSILNKWLHEHVNNPYPTVQEKRELLAKTGLTKLQISNWFINARRRK
Links
Other
Homeodomain
family TFs
Other
Saccharomyces cerevisiae
TFs
55 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy