|
HHAL007380-PA
(Halyomorpha halys)
Homeodomain
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF00046 (Homeobox) |
IPR001356 |
HHAL007380-PA |
T229852_2.00 |
Misc (2018-Jan-19) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
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|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
mirr
M06514_2.00 |
Drosophila melanogaster |
WWACA |
TGTWW |
B1H
Mathelier et al.(2014)
MA0233.1
|
0.867
|
1.000
|
mirr
M06305_2.00 |
Drosophila melanogaster |
NDNWWACA |
TGTWWNHN |
B1H
Zhu et al.(2011)
Mirr_Cell_FBgn0014343
|
0.867
|
1.000
|
mirr
M06306_2.00 |
Drosophila melanogaster |
DDWACA |
TGTWHH |
B1H
Zhu et al.(2011)
Mirr_SOLEXA_FBgn0014343
|
0.867
|
1.000
|
SNAPOd2T00005194001
M02229_2.00 |
Oikopleura dioica |
NNTACATGTDN |
NHACATGTANN |
PBM
Weirauch et al.(2014)
pTH5976
|
0.841
|
0.789
|
Irx3
M00453_2.00 |
Mus musculus |
NNDACAHNNN |
NNNDTGTHNN |
PBM
Berger et al.(2008)
Irx3_0920
|
0.834
|
0.947
|
Irx3
M00454_2.00 |
Mus musculus |
NNDACWHN |
NDWGTHNN |
PBM
Berger et al.(2008)
Irx3_2226
|
0.834
|
0.947
|
Irx3
M03266_2.00 |
Mus musculus |
WWTKTCATGTWR |
YWACATGAMAWW |
SELEX
Jolma et al.(2013)
Irx3_1
|
0.834
|
0.947
|
IRX1
M05283_2.00 |
Homo sapiens |
DDCRHNNNNNNNNDYGHH |
DDCRHNNNNNNNNDYGHH |
SELEX
Yin et al.(2017)
IRX1_eDBD_HT-SELEX
|
0.834
|
0.947
|
IRX3
M05319_2.00 |
Homo sapiens |
DACAHGNWWWWNCDTGTH |
DACAHGNWWWWNCDTGTH |
SELEX
Yin et al.(2017)
IRX3_eDBD_HT-SELEX
|
0.834
|
0.947
|
IRX1
M05284_2.00 |
Homo sapiens |
NNCRHNNNNNNNNDYVHN |
NDBRHNNNNNNNNDYGNN |
SELEX
Yin et al.(2017)
IRX1_eDBD_Methyl-HT-SELEX
|
0.834
|
0.947
|
IRX3
M05320_2.00 |
Homo sapiens |
DACRYRHNWWNDYKCGTW |
WACGMRHNWWNDYRYGTH |
SELEX
Yin et al.(2017)
IRX3_eDBD_Methyl-HT-SELEX
|
0.834
|
0.947
|
For this family, TFs with SR scores > 0.599 will likely have a similar motif |