TF Information

HHAL007461-PA *(Halyomorpha halys)* Homeodomain
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source
PF00046 (Homeobox)	IPR001356	HHAL007461-PA	T229855_2.00	Misc (2018-Jan-19)
NCBI Gene Info: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
No direct experiments
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
vnd M06551_2.00	Drosophila melanogaster	WYTCAAGTR	YACTTGARW	B1H Mathelier et al.(2014) MA0253.1	0.863	0.930
vnd M06377_2.00	Drosophila melanogaster	WYTCAAGTR	YACTTGARW	B1H Zhu et al.(2011) Vnd_Cell_FBgn0003986	0.863	0.930
vnd M06378_2.00	Drosophila melanogaster	KYTSAAGWGY	RCWCTTSARM	B1H Zhu et al.(2011) vnd_FlyReg_FBgn0003986	0.863	0.930
vnd M06379_2.00	Drosophila melanogaster	BTBAAGTR	YACTTVAV	B1H Zhu et al.(2011) Vnd_SOLEXA_FBgn0003986	0.863	0.930
vnd M09683_2.00	Drosophila melanogaster	TCAAGTGB	VCACTTGA	Misc Kulakovskiy et al.(2009) vnd	0.863	0.930
Nkx2-2 M00438_2.00	Mus musculus	NNNRAGDRN	NYHCTYNNN	PBM Berger et al.(2008) Nkx2-2_2823	0.847	0.930
Nkx2-2 M09190_2.00	Mus musculus	NTBRAGWGBBN	NVVCWCTYVAN	Misc Kulakovskiy et al.(2013) NKX22_MOUSE.H11MO.0.A	0.847	0.930
NKX2-2 M10681_2.00	Homo sapiens	WTAAGTRBTT	AAVYACTTAW	Transfac Matys et al.(2006) V$NKX22_01	0.847	0.930
NKX2-2 M10682_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$NKX2B_Q3_01	0.847	0.930
NKX2-2 M10683_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$NKX2B_Q3	0.847	0.930
Nkx2-9 M00520_2.00	Mus musculus	NNNRAGDRBN	NVYHCTYNNN	PBM Berger et al.(2008) Nkx2-9_3082	0.841	0.877
Nkx2-9 M00800_2.00	Mus musculus	NNRAGDRBNN	NNVYHCTYNN	PBM Weirauch et al.(2013) pTH2842	0.841	0.877
Nkx2-9 M09215_2.00	Mus musculus	BTCAAGKRB	VYMCTTGAV	Misc Kulakovskiy et al.(2013) NKX28_MOUSE.H11MO.0.C	0.841	0.877
ceh-22 M00376_2.00	Caenorhabditis elegans	WBRAGTRBNN	NNVYACTYVW	PBM Berger et al.(2006) Ceh-22	0.820	0.825
NKX2-8 M00302_2.00	Homo sapiens	NNRAGDRB	VYHCTYNN	PBM Barrera et al.(2016) NKX2-8_REF	0.809	0.877
NKX2-8 M05149_2.00	Homo sapiens	BTSRAGTGBN	NVCACTYSAV	SELEX Yin et al.(2017) NKX2-8_FL_HT-SELEX	0.809	0.877
NKX2-8 M09145_2.00	Homo sapiens	BTCAAGKRB	VYMCTTGAV	Misc Kulakovskiy et al.(2013) NKX28_HUMAN.H11MO.0.C	0.809	0.877
NKX2-8 M00301_2.00	Homo sapiens	NNRAKDRB	VYHMTYNN	PBM Barrera et al.(2016) NKX2-8_A94T	0.809	0.877
NKX2-8 M05150_2.00	Homo sapiens	GCARTAACGACATC	GATGTCGTTAYTGC	SELEX Yin et al.(2017) NKX2-8_FL_Methyl-HT-SELEX_1	0.809	0.877
NKX2-8 M05151_2.00	Homo sapiens	BTSAAGTGBN	NVCACTTSAV	SELEX Yin et al.(2017) NKX2-8_FL_Methyl-HT-SELEX_2	0.809	0.877
NKX2-8 M05152_2.00	Homo sapiens	BTBAACGAB	VTCGTTVAV	SELEX Yin et al.(2017) NKX2-8_FL_Methyl-HT-SELEX_3	0.809	0.877
scro M03854_2.00	Drosophila melanogaster	NNBRMGTGB	VCACKYVNN	SELEX Nitta et al.(2015) scro_1	0.799	0.877
Nkx2-1 M00385_2.00	Mus musculus	NNRAGDRN	NYHCTYNN	PBM Berger et al.(2008) Titf1_1722	0.783	0.860
Nkx2-4 M00514_2.00	Mus musculus	NNRAGDRBNN	NNVYHCTYNN	PBM Berger et al.(2008) Nkx2-4_3074	0.783	0.860
NKX2-1 M09146_2.00	Homo sapiens	BTKGAGWGBN	NVCWCTCMAV	Misc Kulakovskiy et al.(2013) NKX21_HUMAN.H11MO.0.A	0.783	0.860
Nkx2-1 M09171_2.00	Mus musculus	NBTKGAGWGB	VCWCTCMAVN	Misc Kulakovskiy et al.(2013) NKX21_MOUSE.H11MO.0.A	0.783	0.860
Nkx2-1 M09563_2.00	Mus musculus	BTBRAGWGBH	DVCWCTYVAV	Misc Heinz et al.(2010) LungAC-Nkx2.1_GSE43252	0.783	0.860
NKX2-1 M10694_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$TITF1_Q3	0.783	0.860
NKX2-1 M10695_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$TTF1_Q5_01	0.783	0.860
NKX2-1 M10696_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$TTF1_Q5	0.783	0.860
NKX2-1 M10697_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$TTF1_Q6	0.783	0.860
ceh-24 M02181_2.00	Caenorhabditis elegans	NNRAKWRNN	NNYWMTYNN	PBM Weirauch et al.(2014) pTH6327	0.781	0.772
Nkx2-3 M00497_2.00	Mus musculus	NNRAGDRNN	NNYHCTYNN	PBM Berger et al.(2008) Nkx2-3_3435	0.742	0.807
NKX2-3 M05042_2.00	Homo sapiens	NNBAAGTGBN	NVCACTTVNN	SELEX Yin et al.(2017) NKX2-3_eDBD_HT-SELEX	0.742	0.807
NKX2-3 M05045_2.00	Homo sapiens	BNBAAGTGBN	NVCACTTVNV	SELEX Yin et al.(2017) NKX2-3_FL_HT-SELEX	0.742	0.807
NKX2-3 M05043_2.00	Homo sapiens	BNBAAGTGBN	NVCACTTVNV	SELEX Yin et al.(2017) NKX2-3_eDBD_Methyl-HT-SELEX_1	0.742	0.807
NKX2-3 M05044_2.00	Homo sapiens	SDYAACGHB	VDCGTTRHS	SELEX Yin et al.(2017) NKX2-3_eDBD_Methyl-HT-SELEX_2	0.742	0.807
NKX2-3 M05046_2.00	Homo sapiens	BNBAAGTGBN	NVCACTTVNV	SELEX Yin et al.(2017) NKX2-3_FL_Methyl-HT-SELEX_1	0.742	0.807
NKX2-3 M05047_2.00	Homo sapiens	SWYAACSHB	VDSGTTRWS	SELEX Yin et al.(2017) NKX2-3_FL_Methyl-HT-SELEX_2	0.742	0.807
NKX2-5 M00323_2.00	Homo sapiens	NWYAAGTGSNN	NNSCACTTRWN	PBM Barrera et al.(2016) NKX2-5_REF	0.741	0.754
Nkx2-5 M00404_2.00	Mus musculus	NNNRAGDRBN	NVYHCTYNNN	PBM Berger et al.(2008) Nkx2-5_3436	0.741	0.754
NKX2-5 M05346_2.00	Homo sapiens	BHYAAGTGBN	NVCACTTRDV	SELEX Yin et al.(2017) NKX2-5_FL_HT-SELEX	0.741	0.754
Nkx2-5 M02686_2.00	Mus musculus	WTAAKWK	MWMTTAW	SELEX Mathelier et al.(2014) MA0063.1	0.741	0.754
Nkx2-5 M08136_2.00	Mus musculus	SYTGAGWGSYH	DRSCWCTCARS	ChIP-seq Mathelier et al.(2014) MA0503.1	0.741	0.754
NKX2-5 M09163_2.00	Homo sapiens	BKRAGWGV	BCWCTYMV	Misc Kulakovskiy et al.(2013) NKX25_HUMAN.H11MO.0.B	0.741	0.754
Nkx2-5 M09177_2.00	Mus musculus	NBYBRAGTGS	SCACTYVRVN	Misc Kulakovskiy et al.(2013) NKX25_MOUSE.H11MO.0.A	0.741	0.754
Nkx2-5 M09567_2.00	Mus musculus	HBRAGWGBNN	NNVCWCTYVD	Misc Heinz et al.(2010) HL1-Nkx2.5.biotin_GSE21529	0.741	0.754
NKX2-5 M10742_2.00	Homo sapiens	TYAAGTG	CACTTRA	Transfac Matys et al.(2006) V$NKX25_01	0.741	0.754
NKX2-5 M10743_2.00	Homo sapiens	CWTAATTV	BAATTAWG	Transfac Matys et al.(2006) V$NKX25_02	0.741	0.754
NKX2-5 M10744_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$NKX25_Q5	0.741	0.754
NKX2-5 M10745_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$NKX25_Q6	0.741	0.754
NKX2-5 M05347_2.00	Homo sapiens	BTYAAGTGGN	NCCACTTRAV	SELEX Yin et al.(2017) NKX2-5_FL_Methyl-HT-SELEX_1	0.741	0.754
NKX2-5 M05348_2.00	Homo sapiens	BTYAACGAB	VTCGTTRAV	SELEX Yin et al.(2017) NKX2-5_FL_Methyl-HT-SELEX_2	0.741	0.754
NKX2-5 M00322_2.00	Homo sapiens	NNNRNNN	NNNYNNN	PBM Barrera et al.(2016) NKX2-5_R190C	0.741	0.737
NKX2-5 M00324_2.00	Homo sapiens	NHNNNNN	NNNNNDN	PBM Barrera et al.(2016) NKX2-5_T178M	0.741	0.737
ceh-28 M08210_2.00	Caenorhabditis elegans	AATCGATW	WATCGATT	ChIP-seq Contrino et al.(2012) Mw138	0.736	0.649
NKX2-5 M00321_2.00	Homo sapiens	HNAAGTRBNN	NNVYACTTND	PBM Barrera et al.(2016) NKX2-5_R161P	0.736	0.737
Nkx2-6 M00496_2.00	Mus musculus	HYAAGTRBNN	NNVYACTTRD	PBM Berger et al.(2008) Nkx2-6_3437	0.718	0.737
tin M00559_2.00	Drosophila melanogaster	NWYAAGTGGNN	NNCCACTTRWN	PBM Busser et al.(2012a) Tin	0.718	0.614
tin M03809_2.00	Drosophila melanogaster	BTYAAGTGSN	NSCACTTRAV	SELEX Nitta et al.(2015) tin_1	0.718	0.614
tin M06284_2.00	Drosophila melanogaster	BTYAAGTG	CACTTRAV	B1H Zhu et al.(2011) Tin_Cell_FBgn0004110	0.718	0.614
tin M06285_2.00	Drosophila melanogaster	BCTCAAGTGSVN	NBSCACTTGAGV	B1H Zhu et al.(2011) tin_FlyReg_FBgn0004110	0.718	0.614
tin M06286_2.00	Drosophila melanogaster	BWYAAGTR	YACTTRWV	B1H Zhu et al.(2011) Tin_SOLEXA_FBgn0004110	0.718	0.614
tin M08421_2.00	Drosophila melanogaster	DBTCRAGTGS	SCACTYGAVH	ChIP-chip Mathelier et al.(2014) MA0247.2	0.718	0.614
NKX2-5 M00320_2.00	Homo sapiens	NHBAAKWRN	NYWMTTVDN	PBM Barrera et al.(2016) NKX2-5_K183E	0.707	0.737
Q24782_9CNID M02206_2.00	Eleutheria dichotoma	TTAATTAA	TTAATTAA	PBM Weirauch et al.(2014) pTH5486	0.613	0.491
For this family, TFs with SR scores > 0.599* will likely have a similar motif*