NECAME_02262 (Necator americanus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox) IPR001356 NECAME_02262 T235343_2.00 WormBase:ParaSite (2015-Oct-22)

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Nkx2-1
M00385_2.00
Mus musculus
NNRAGDRN

NYHCTYNN
PBM
Berger et al.(2008)
Titf1_1722
0.820 0.719
Nkx2-4
M00514_2.00
Mus musculus
NNRAGDRBNN

NNVYHCTYNN
PBM
Berger et al.(2008)
Nkx2-4_3074
0.820 0.719
NKX2-1
M09146_2.00
Homo sapiens
BTKGAGWGBN

NVCWCTCMAV
Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A
0.820 0.719
Nkx2-1
M09171_2.00
Mus musculus
NBTKGAGWGB

VCWCTCMAVN
Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A
0.820 0.719
Nkx2-1
M09563_2.00
Mus musculus
BTBRAGWGBH

DVCWCTYVAV
Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252
0.820 0.719
NKX2-1
M10694_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TITF1_Q3
0.820 0.719
NKX2-1
M10695_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5_01
0.820 0.719
NKX2-1
M10696_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q5
0.820 0.719
NKX2-1
M10697_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$TTF1_Q6
0.820 0.719
ceh-24
M02181_2.00
Caenorhabditis elegans
NNRAKWRNN

NNYWMTYNN
PBM
Weirauch et al.(2014)
pTH6327
0.820 0.702
scro
M03854_2.00
Drosophila melanogaster
NNBRMGTGB

VCACKYVNN
SELEX
Nitta et al.(2015)
scro_1
0.815 0.719
ceh-28
M08210_2.00
Caenorhabditis elegans
AATCGATW

WATCGATT
ChIP-seq
Contrino et al.(2012)
Mw138
0.783 0.649
Nkx2-3
M00497_2.00
Mus musculus
NNRAGDRNN

NNYHCTYNN
PBM
Berger et al.(2008)
Nkx2-3_3435
0.780 0.649
NKX2-3
M05042_2.00
Homo sapiens
NNBAAGTGBN

NVCACTTVNN
SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX
0.780 0.649
NKX2-3
M05045_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX
0.780 0.649
NKX2-3
M05043_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1
0.780 0.649
NKX2-3
M05044_2.00
Homo sapiens
SDYAACGHB

VDCGTTRHS
SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2
0.780 0.649
NKX2-3
M05046_2.00
Homo sapiens
BNBAAGTGBN

NVCACTTVNV
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1
0.780 0.649
NKX2-3
M05047_2.00
Homo sapiens
SWYAACSHB

VDSGTTRWS
SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2
0.780 0.649
NKX2-5
M00323_2.00
Homo sapiens
NWYAAGTGSNN

NNSCACTTRWN
PBM
Barrera et al.(2016)
NKX2-5_REF
0.780 0.632
Nkx2-5
M00404_2.00
Mus musculus
NNNRAGDRBN

NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-5_3436
0.780 0.632
NKX2-5
M05346_2.00
Homo sapiens
BHYAAGTGBN

NVCACTTRDV
SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX
0.780 0.632
Nkx2-5
M02686_2.00
Mus musculus
WTAAKWK

MWMTTAW
SELEX
Mathelier et al.(2014)
MA0063.1
0.780 0.632
Nkx2-5
M08136_2.00
Mus musculus
SYTGAGWGSYH

DRSCWCTCARS
ChIP-seq
Mathelier et al.(2014)
MA0503.1
0.780 0.632
NKX2-5
M09163_2.00
Homo sapiens
BKRAGWGV

BCWCTYMV
Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B
0.780 0.632
Nkx2-5
M09177_2.00
Mus musculus
NBYBRAGTGS

SCACTYVRVN
Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A
0.780 0.632
Nkx2-5
M09567_2.00
Mus musculus
HBRAGWGBNN

NNVCWCTYVD
Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529
0.780 0.632
NKX2-5
M10742_2.00
Homo sapiens
TYAAGTG

CACTTRA
Transfac
Matys et al.(2006)
V$NKX25_01
0.780 0.632
NKX2-5
M10743_2.00
Homo sapiens
CWTAATTV

BAATTAWG
Transfac
Matys et al.(2006)
V$NKX25_02
0.780 0.632
NKX2-5
M10744_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q5
0.780 0.632
NKX2-5
M10745_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX25_Q6
0.780 0.632
NKX2-5
M00321_2.00
Homo sapiens
HNAAGTRBNN

NNVYACTTND
PBM
Barrera et al.(2016)
NKX2-5_R161P
0.780 0.632
NKX2-5
M00324_2.00
Homo sapiens
NHNNNNN

NNNNNDN
PBM
Barrera et al.(2016)
NKX2-5_T178M
0.780 0.632
NKX2-5
M05347_2.00
Homo sapiens
BTYAAGTGGN

NCCACTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1
0.780 0.632
NKX2-5
M05348_2.00
Homo sapiens
BTYAACGAB

VTCGTTRAV
SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2
0.780 0.632
NKX2-5
M00322_2.00
Homo sapiens
NNNRNNN

NNNYNNN
PBM
Barrera et al.(2016)
NKX2-5_R190C
0.780 0.614
tin
M00559_2.00
Drosophila melanogaster
NWYAAGTGGNN

NNCCACTTRWN
PBM
Busser et al.(2012a)
Tin
0.771 0.667
tin
M03809_2.00
Drosophila melanogaster
BTYAAGTGSN

NSCACTTRAV
SELEX
Nitta et al.(2015)
tin_1
0.771 0.667
tin
M06284_2.00
Drosophila melanogaster
BTYAAGTG

CACTTRAV
B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110
0.771 0.667
tin
M06285_2.00
Drosophila melanogaster
BCTCAAGTGSVN

NBSCACTTGAGV
B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110
0.771 0.667
tin
M06286_2.00
Drosophila melanogaster
BWYAAGTR

YACTTRWV
B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110
0.771 0.667
tin
M08421_2.00
Drosophila melanogaster
DBTCRAGTGS

SCACTYGAVH
ChIP-chip
Mathelier et al.(2014)
MA0247.2
0.771 0.667
vnd
M06551_2.00
Drosophila melanogaster
WYTCAAGTR

YACTTGARW
B1H
Mathelier et al.(2014)
MA0253.1
0.767 0.702
vnd
M06377_2.00
Drosophila melanogaster
WYTCAAGTR

YACTTGARW
B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986
0.767 0.702
vnd
M06378_2.00
Drosophila melanogaster
KYTSAAGWGY

RCWCTTSARM
B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986
0.767 0.702
vnd
M06379_2.00
Drosophila melanogaster
BTBAAGTR

YACTTVAV
B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986
0.767 0.702
vnd
M09683_2.00
Drosophila melanogaster
TCAAGTGB

VCACTTGA
Misc
Kulakovskiy et al.(2009)
vnd
0.767 0.702
Nkx2-2
M00438_2.00
Mus musculus
NNNRAGDRN

NYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-2_2823
0.767 0.684
Nkx2-2
M09190_2.00
Mus musculus
NTBRAGWGBBN

NVVCWCTYVAN
Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A
0.767 0.684
NKX2-2
M10681_2.00
Homo sapiens
WTAAGTRBTT

AAVYACTTAW
Transfac
Matys et al.(2006)
V$NKX22_01
0.767 0.684
NKX2-2
M10682_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3_01
0.767 0.684
NKX2-2
M10683_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NKX2B_Q3
0.767 0.684
Nkx2-9
M00520_2.00
Mus musculus
NNNRAGDRBN

NVYHCTYNNN
PBM
Berger et al.(2008)
Nkx2-9_3082
0.761 0.667
Nkx2-9
M00800_2.00
Mus musculus
NNRAGDRBNN

NNVYHCTYNN
PBM
Weirauch et al.(2013)
pTH2842
0.761 0.667
Nkx2-9
M09215_2.00
Mus musculus
BTCAAGKRB

VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C
0.761 0.667
Nkx2-6
M00496_2.00
Mus musculus
HYAAGTRBNN

NNVYACTTRD
PBM
Berger et al.(2008)
Nkx2-6_3437
0.758 0.596
ceh-22
M00376_2.00
Caenorhabditis elegans
WBRAGTRBNN

NNVYACTYVW
PBM
Berger et al.(2006)
Ceh-22
0.750 0.702
NKX2-5
M00320_2.00
Homo sapiens
NHBAAKWRN

NYWMTTVDN
PBM
Barrera et al.(2016)
NKX2-5_K183E
0.747 0.614
NKX2-8
M00302_2.00
Homo sapiens
NNRAGDRB

VYHCTYNN
PBM
Barrera et al.(2016)
NKX2-8_REF
0.729 0.649
NKX2-8
M05149_2.00
Homo sapiens
BTSRAGTGBN

NVCACTYSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX
0.729 0.649
NKX2-8
M09145_2.00
Homo sapiens
BTCAAGKRB

VYMCTTGAV
Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C
0.729 0.649
NKX2-8
M00301_2.00
Homo sapiens
NNRAKDRB

VYHMTYNN
PBM
Barrera et al.(2016)
NKX2-8_A94T
0.729 0.649
NKX2-8
M05150_2.00
Homo sapiens
GCARTAACGACATC

GATGTCGTTAYTGC
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1
0.729 0.649
NKX2-8
M05151_2.00
Homo sapiens
BTSAAGTGBN

NVCACTTSAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2
0.729 0.649
NKX2-8
M05152_2.00
Homo sapiens
BTBAACGAB

VTCGTTVAV
SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3
0.729 0.649
Q24782_9CNID
M02206_2.00
Eleutheria dichotoma
TTAATTAA

TTAATTAA
PBM
Weirauch et al.(2014)
pTH5486
0.600 0.474
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
NECAME_02262 Homeodomain 131 187

Links

Other Homeodomain family TFs
Other Necator americanus TFs

830 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ACYPI31512 Acyrthosiphon pisum ACYPI31512 I 0.000
ANCCEY_04739 Ancylostoma ceylanicum ANCCEY_04739 I 0.000
ANCDUO_13968 Ancylostoma duodenale ANCDUO_13968 I 0.000
ACAC_0000050701 Angiostrongylus cantonensis ACAC_0000050701 I 0.000
ACOC_0000924001 Angiostrongylus costaricensis ACOC_0000924001 I 0.000
AALB006664 Anopheles albimanus AALB006664 N 0.000
AATE018011 Anopheles atroparvus AATE018011 I 0.000
ACOM027979 Anopheles coluzzii ACOM027979 I 0.000
ADAC002899 Anopheles darlingi ADAC002899 N 0.000
AFAF001557 Anopheles farauti AFAF001557 I 0.000
AFAF020264 Anopheles farauti AFAF020264 I 0.000
AMAM005266 Anopheles maculatus AMAM005266 N 0.000
AMAM009924 Anopheles maculatus AMAM009924 I 0.000
AMAM003778 Anopheles maculatus AMAM003778 I 0.000
ASU_06642 Ascaris suum ASU_06642 I 0.000
ACEP14857 Atta cephalotes ACEP14857 I 0.000
ENSBTAG00000003540 Bos taurus ENSBTAG00000003540 I 0.000
BXY_0842900 Bursaphelenchus xylophilus BXY_0842900 I 0.000
CBN09920 Caenorhabditis brenneri CBN09920 I 0.000
CBN18838 Caenorhabditis brenneri CBN18838 I 0.000
CBG03854 Caenorhabditis briggsae CBG03854 I 0.000
ztf-11 Caenorhabditis elegans WBGene00009939 D 0.000
CJA03417 Caenorhabditis japonica CJA03417 I 0.000
CRE08084 Caenorhabditis remanei CRE08084 I 0.000
Cmyd_10014184 Chelonia mydas Cmyd_10014184 I 0.000
CLEC010165 Cimex lectularius CLEC010165 N 0.000
CpipJ_CPIJ018573 Culex pipiens CpipJ_CPIJ018573 N 0.000
CPIJ018573 Culex quinquefasciatus CPIJ018573 N 0.000
YQE_11977 Dendroctonus ponderosae YQE_11977 I 0.000
DICVIV_01967 Dictyocaulus viviparus DICVIV_01967 I 0.000
nDi.2.2.2.g06992 Dirofilaria immitis nDi.2.2.2.g06992 I 0.000
CG43689 Drosophila melanogaster FBgn0263772 I 0.000
GI16394 Drosophila mojavensis FBgn0139142 I 0.000
ECANG7_03405 Echinococcus canadensis ECANG7_03405 N 0.000
EmuJ_000598400 Echinococcus multilocularis EmuJ_000598400 N 0.000
EVEC_0001307101 Enterobius vermicularis EVEC_0001307101 I 0.000
MYT1 Erinaceus europaeus ENSEEUG00000004157 N 0.000
HHAL001110-PA Halyomorpha halys HHAL001110-PA I 0.000
HelroG85268 Helobdella robusta HelroG85268 I 0.000
Hba_17025 Heterorhabditis bacteriophora Hba_17025 I 0.000
MYT1L Homo sapiens ENSG00000186487 I 0.000
TTAC_0000856801 Hydatigera taeniaeformis TTAC_0000856801 N 0.000
HDID_0000016901 Hymenolepis diminuta HDID_0000016901 N 0.000
ISCW018799 Ixodes scapularis ISCW018799 I 0.000
nLs.2.1.2.g09672 Litomosoides sigmodontis nLs.2.1.2.g09672 I 0.000
LCUP002242 Lucilia cuprina LCUP002242 I 0.000
MYT1L Macaca mulatta ENSMMUG00000009310 I 0.000
Minc05804 Meloidogyne incognita Minc05804 I 0.000
MCOS_0000008701 Mesocestoides corti MCOS_0000008701 N 0.000
NECAME_10938 Necator americanus NECAME_10938 I 0.000
NBR_0001165301 Nippostrongylus brasiliensis NBR_0001165301 I 0.000
Ocbimv22028296m.g Octopus bimaculoides Ocbimv22028296m.g N 0.000
Ocbimv22028295m.g Octopus bimaculoides Ocbimv22028295m.g I 0.000
OESDEN_24201 Oesophagostomum dentatum OESDEN_24201 I 0.000
WBGene00238210 Onchocerca volvulus WBGene00238210 I 0.000
PTRK_0001788400 Parastrongyloides trichosuri PTRK_0001788400 I 0.000
RSKR_0000214800 Rhabditophanes kr3021 RSKR_0000214800 I 0.000
nRc.2.0.1.g21954 Romanomermis culicivorax nRc.2.0.1.g21954 N 0.000
SSLN_0001285301 Schistocephalus solidus SSLN_0001285301 N 0.000
SMU15021651 Schmidtea mediterranea SMU15021651 N 0.000
SMU15028607 Schmidtea mediterranea SMU15028607 I 0.000
SBAD_0000885801 Soboliphyme baturini SBAD_0000885801 N 0.000
L596_g1281 Steinernema carpocapsae L596_g1281 I 0.000
L889_g28085 Steinernema feltiae L889_g28085 I 0.000
L893_g1446 Steinernema glaseri L893_g1446 I 0.000
SPAL_0000489100 Strongyloides papillosus SPAL_0000489100 I 0.000
SPAL_0000892700 Strongyloides papillosus SPAL_0000892700 I 0.000
SSTP_0000574400 Strongyloides stercoralis SSTP_0000574400 I 0.000
SVE_1952800 Strongyloides venezuelensis SVE_1952800 I 0.000
SVE_1935100 Strongyloides venezuelensis SVE_1935100 I 0.000
SMUV_0000666101 Syphacia muris SMUV_0000666101 I 0.000
TASK_0000444001 Taenia asiatica TASK_0000444001 N 0.000
TELCIR_22038 Teladorsagia circumcincta TELCIR_22038 I 0.000
TELCIR_26151 Teladorsagia circumcincta TELCIR_26151 I 0.000