nub (Drosophila melanogaster)
Homeodomain,POU

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox)
PF00157 (Pou) 		IPR001356
IPR000327 		FBgn0085424 T238719_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including generation of neurons; regulation of cellular biosynthetic process; and regulation of neural precursor cell proliferation. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; ectoderm; extended germ band embryo; larval midline neurons; and presumptive embryonic/larval system. Used to study immune system disease. Orthologous to human POU2F1 (POU class 2 homeobox 1) and POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nub
M03906_2.00		 Drosophila melanogaster
DTATGYWAATNN
NNATTWRCATAH		 SELEX
Nitta et al.(2015)
nub_1		 (Direct) (Direct)
nub
M06556_2.00		 Drosophila melanogaster
TATGYAAATNMD
HKNATTTRCATA		 B1H
Mathelier et al.(2014)
MA0197.2		 (Direct) (Direct)
nub
M09685_2.00		 Drosophila melanogaster
NDTATGYAARN
NYTTRCATAHN		 Misc
Kulakovskiy et al.(2009)
nub		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.993 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0111554 POU 784 855
FBpp0111554 Homeodomain 884 940
FBpp0111555 POU 424 495
FBpp0111555 Homeodomain 524 580
FBpp0309559 POU 424 495
FBpp0309559 Homeodomain 524 580

Links

Other Homeodomain,POU family TFs
Other Drosophila melanogaster TFs

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3 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action