| NCBI Gene Info:Enables chromatin DNA binding activity and methylated histone binding activity. Involved in heterochromatin assembly by small RNA. Located in pericentric heterochromatin and polytene chromosome. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; extended germ band embryo; and germ layer. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune disease (multiple); carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta). [provided by Alliance of Genome Resources, Apr 2022] |