NCBI Gene Info:Predicted to enable DNA binding activity and pyrimidine-specific mismatch base pair DNA N-glycosylase activity. Involved in response to estradiol. Predicted to be located in chromatin; cytoplasm; and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal carcinoma; esophagus squamous cell carcinoma; lung cancer; and rheumatoid arthritis. Orthologous to human MBD4 (methyl-CpG binding domain 4, DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022] |