pros-1 (Caenorhabditis elegans)
Prospero

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF05044 (HPD) IPR007738 WBGene00000448 T316617_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in glial cell development. Located in nucleus. Is expressed in several structures, including labial sensillum. Orthologous to human PROX1 (prospero homeobox 1) and PROX2 (prospero homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
pros-1
M00708_2.00		 Caenorhabditis elegans
NNBRAGRHDN
NHDYCTYVNN		 PBM
Narasimhan et al.(2015)
pTH9164		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00708_2.00 Prospero 131 284

DNA Binding Domains

Protein ID Domain From To Sequence
K12H4.1 Prospero 437 590

Links

Other Prospero family TFs
Other Caenorhabditis elegans TFs

66 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
nOo.2.0.1.g10265 Onchocerca ochengi nOo.2.0.1.g10265 I 0.960
LOAG_14553 Loa loa LOAG_14553 I 0.959
WUBG_06449 Wuchereria bancrofti WUBG_06449 I 0.959
CBN10125 Caenorhabditis brenneri CBN10125 I 0.948
ACOC_0000703501 Angiostrongylus costaricensis ACOC_0000703501 I 0.947
CBG22984 Caenorhabditis briggsae CBG22984 I 0.922
ANCCAN_24706 Ancylostoma caninum ANCCAN_24706 I 0.920
ANCCAN_23624 Ancylostoma caninum ANCCAN_23624 I 0.920
ANCDUO_15205 Ancylostoma duodenale ANCDUO_15205 I 0.920
NECAME_07738 Necator americanus NECAME_07738 I 0.920
SVUK_0000405601 Strongylus vulgaris SVUK_0000405601 I 0.920
DICVIV_00921 Dictyocaulus viviparus DICVIV_00921 I 0.920
D918_02805 Trichuris suis D918_02805 I 0.920
CGOC_0000822101 Cylicostephanus goldi CGOC_0000822101 I 0.920
ANCCEY_02877 Ancylostoma ceylanicum ANCCEY_02877 I 0.920
HCOI02128500 Haemonchus contortus HCOI02128500 I 0.918
D917_07791 Trichinella nativa D917_07791 I 0.900
CJA12444 Caenorhabditis japonica CJA12444 I 0.896
CRE23850 Caenorhabditis remanei CRE23850 I 0.886
TELCIR_21732 Teladorsagia circumcincta TELCIR_21732 I 0.885
TELCIR_22329 Teladorsagia circumcincta TELCIR_22329 I 0.885
nLs.2.1.2.g05095 Litomosoides sigmodontis nLs.2.1.2.g05095 I 0.875
nAv.1.0.1.g04749 Acanthocheilonema viteae nAv.1.0.1.g04749 I 0.873
SBAD_0000068201 Soboliphyme baturini SBAD_0000068201 I 0.860
SINV18378 Solenopsis invicta SINV18378 I 0.840
YQE_10516 Dendroctonus ponderosae YQE_10516 I 0.840
AMIN002618 Anopheles minimus AMIN002618 I 0.840
ACUA003826 Anopheles culicifacies ACUA003826 I 0.840
AEPI001687 Anopheles epiroticus AEPI001687 I 0.840
AARA009757 Anopheles arabiensis AARA009757 I 0.840
Cflo_00868--XP_392355.3_APIME Camponotus floridanus Cflo_00868--XP_392355.3_APIME I 0.840
PPAI010076 Phlebotomus papatasi PPAI010076 I 0.837
HCOI01824000 Haemonchus contortus HCOI01824000 I 0.799
A_05794 Schistosoma haematobium A_05794 I 0.792
NBR_0000066801 Nippostrongylus brasiliensis NBR_0000066801 I 0.792
ADIR006616 Anopheles dirus ADIR006616 I 0.774
WBGene00244521 Onchocerca volvulus WBGene00244521 I 0.766
Bm5024 Brugia malayi Bm5024 I 0.753
CPIJ004052 Culex quinquefasciatus CPIJ004052 I 0.750
CpipJ_CPIJ004052 Culex pipiens CpipJ_CPIJ004052 I 0.750
DME_0000841401 Dracunculus medinensis DME_0000841401 I 0.747
ASU_00242 Ascaris suum ASU_00242 I 0.747
ASTEI07078 Anopheles stephensi ASTEI07078 I 0.745
SSTP_0000359900 Strongyloides stercoralis SSTP_0000359900 I 0.740
L892_g25141 Steinernema scapterisci L892_g25141 I 0.740
L889_g22574 Steinernema feltiae L889_g22574 I 0.740
L596_g9976 Steinernema carpocapsae L596_g9976 I 0.740
ACHR007729 Anopheles christyi ACHR007729 I 0.737
GL11998 Drosophila persimilis FBgn0149606 I 0.737
AALB003340 Anopheles albimanus AALB003340 I 0.737
PTRK_0001568700 Parastrongyloides trichosuri PTRK_0001568700 I 0.734
TMUE_s0183000500 Trichuris muris TMUE_s0183000500 I 0.734
L898_g8569 Steinernema monticolum L898_g8569 I 0.734
SPAL_0001624500 Strongyloides papillosus SPAL_0001624500 I 0.734
SVE_0442300 Strongyloides venezuelensis SVE_0442300 I 0.734
TTRE_0000134301 Trichuris trichiura TTRE_0000134301 I 0.727
EVEC_0001110501 Enterobius vermicularis EVEC_0001110501 I 0.727
EFV53283 Trichinella spiralis EFV53283 I 0.727
ANCDUO_20174 Ancylostoma duodenale ANCDUO_20174 I 0.724
L893_g28279 Steinernema glaseri L893_g28279 I 0.721
NECAME_07739 Necator americanus NECAME_07739 I 0.714
AQUA008561 Anopheles quadriannulatus AQUA008561 I 0.712
PHUM334550 Pediculus humanus PHUM334550 I 0.708
MCOS_0000195601 Mesocestoides corti MCOS_0000195601 I 0.707
DAPPUDRAFT_290533 Daphnia pulex DAPPUDRAFT_290533 I 0.701
ACYPI001696 Acyrthosiphon pisum ACYPI001696 I 0.701