NFATC3 (Homo sapiens)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSG00000072736 T317166_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NFATC3
M02440_2.00
Homo sapiens
DNTTTCCRNN

NNYGGAAANH
PBM
Weirauch et al.(2014)
pTH9192
(Direct) (Direct)
NFATC3
M05693_2.00
Homo sapiens
WNTTTCCRYN

NRYGGAAANW
SELEX
Yin et al.(2017)
NFATC3_eDBD_HT-SELEX_1
(Direct) (Direct)
NFATC3
M05694_2.00
Homo sapiens
NTTTCCATGGAAAN

NTTTCCATGGAAAN
SELEX
Yin et al.(2017)
NFATC3_eDBD_HT-SELEX_2
(Direct) (Direct)
NFATC3
M05695_2.00
Homo sapiens
DYGGAAANNNNNNNTTTCCRH

DYGGAAANNNNNNNTTTCCRH
SELEX
Yin et al.(2017)
NFATC3_eDBD_HT-SELEX_3
(Direct) (Direct)
NFATC3
M05696_2.00
Homo sapiens
WNTTTCCRYN

NRYGGAAANW
SELEX
Yin et al.(2017)
NFATC3_eDBD_Methyl-HT-SELEX_1
(Direct) (Direct)
NFATC3
M05697_2.00
Homo sapiens
NTTTCCRYGGAAAN

NTTTCCRYGGAAAN
SELEX
Yin et al.(2017)
NFATC3_eDBD_Methyl-HT-SELEX_2
(Direct) (Direct)
NFATC3
M05698_2.00
Homo sapiens
RYGGAAANHNNNDNTTTCCRY

RYGGAAANHNNNDNTTTCCRY
SELEX
Yin et al.(2017)
NFATC3_eDBD_Methyl-HT-SELEX_3
(Direct) (Direct)
NFATC3
M09343_2.00
Homo sapiens
RDTTTTCCA

TGGAAAAHY
Misc
Kulakovskiy et al.(2013)
NFAC3_HUMAN.H11MO.0.B
(Direct) (Direct)
NFATC3
M11217_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT4_Q3
(Direct) (Direct)
NFATC3
M11218_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT4_Q5
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Nfatc3
M09359_2.00
Mus musculus
RDTTTTCCA

TGGAAAAHY
Misc
Kulakovskiy et al.(2013)
NFAC3_MOUSE.H11MO.0.B
0.993 0.993
Nfatc1
M09360_2.00
Mus musculus
KABTCANWBTTTCCW

WGGAAAVWNTGAVTM
Misc
Kulakovskiy et al.(2013)
NFAC1_MOUSE.H11MO.0.A
0.860 0.860
NFATC4
M01306_2.00
Homo sapiens
NNNWWWVYRN

NYRBWWWNNN
PBM
Lambert et al.(2019)
pTH9347
0.853 0.853
NFATC1
M02443_2.00
Meleagris gallopavo
NNTTTCCRNN

NNYGGAAANN
PBM
Weirauch et al.(2014)
pTH8315
0.853 0.853
NFATC4
M05701_2.00
Homo sapiens
DBTTTCCRYN

NRYGGAAAVH
SELEX
Yin et al.(2017)
NFATC4_eDBD_HT-SELEX_1
0.853 0.853
NFATC4
M05702_2.00
Homo sapiens
NKTTCCATGGAAMV

BKTTCCATGGAAMN
SELEX
Yin et al.(2017)
NFATC4_eDBD_HT-SELEX_2
0.853 0.853
NFATC4
M09345_2.00
Homo sapiens
HNDBTTTCCN

NGGAAAVHND
Misc
Kulakovskiy et al.(2013)
NFAC4_HUMAN.H11MO.0.C
0.853 0.853
Nfatc4
M09354_2.00
Mus musculus
HNDBTTTCCN

NGGAAAVHND
Misc
Kulakovskiy et al.(2013)
NFAC4_MOUSE.H11MO.0.C
0.853 0.853
NFATC4
M11219_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT3_Q3_01
0.853 0.853
NFATC4
M11220_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT3_Q3
0.853 0.853
NFATC4
M05703_2.00
Homo sapiens
DNTTTCCRYN

NRYGGAAANH
SELEX
Yin et al.(2017)
NFATC4_eDBD_Methyl-HT-SELEX_1
0.853 0.853
NFATC4
M05704_2.00
Homo sapiens
NKTTCCRYGGAAMN

NKTTCCRYGGAAMN
SELEX
Yin et al.(2017)
NFATC4_eDBD_Methyl-HT-SELEX_2
0.853 0.853
NFATC1
M02444_2.00
Monodelphis domestica
NNDTTCCDNN

NNHGGAAHNN
PBM
Weirauch et al.(2014)
pTH8401
0.846 0.846
nfatc1
M02446_2.00
Xenopus tropicalis
NNTTTCCRNN

NNYGGAAANN
PBM
Weirauch et al.(2014)
pTH8557
0.846 0.846
NFATC1
M03449_2.00
Homo sapiens
HKGRAAADDNWBTTTCCAYN

NRTGGAAAVWNHHTTTYCMD
SELEX
Jolma et al.(2013)
NFATC1_1
0.839 0.839
NFATC1
M03450_2.00
Homo sapiens
TTTCCAYWRYGGAAA

TTTCCRYWRTGGAAA
SELEX
Jolma et al.(2013)
NFATC1_2
0.839 0.839
NFATC1
M03451_2.00
Homo sapiens
NTTTCCATGGAAAN

NTTTCCATGGAAAN
SELEX
Jolma et al.(2013)
NFATC1_3
0.839 0.839
NFATC1
M02747_2.00
Homo sapiens
DTTCCRYGGAA

TTCCRYGGAAH
SELEX
Jolma et al.(2010)
NFATc1_dimer
0.839 0.839
NFATC1
M02748_2.00
Homo sapiens
GGAANDTTCC

GGAAHNTTCC
SELEX
Jolma et al.(2010)
NFATc1_dimer_type2
0.839 0.839
NFATC1
M02749_2.00
Homo sapiens
WDTTTCCAY

RTGGAAAHW
SELEX
Jolma et al.(2010)
NFATc1_monomer
0.839 0.839
NFATC1
M05711_2.00
Homo sapiens
NTTTCCATGGAAAN

NTTTCCATGGAAAN
SELEX
Yin et al.(2017)
NFATC1_eDBD_HT-SELEX_1
0.839 0.839
NFATC1
M05712_2.00
Homo sapiens
NTTTCCRYNNRYGGAAAN

NTTTCCRYNNRYGGAAAN
SELEX
Yin et al.(2017)
NFATC1_eDBD_HT-SELEX_2
0.839 0.839
NFATC1
M09349_2.00
Homo sapiens
HBYHWBWBTTTCCWB

VWGGAAAVWVWDRVD
Misc
Kulakovskiy et al.(2013)
NFAC1_HUMAN.H11MO.0.B
0.839 0.839
NFATC1
M09625_2.00
Homo sapiens
WBTTTCCAYY

RRTGGAAAVW
Misc
Heinz et al.(2010)
Jurkat-NFATC1_Jolma_et_al.
0.839 0.839
NFATC1
M11232_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT2_Q4
0.839 0.839
NFATC1
M11233_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT2_Q5_01
0.839 0.839
NFATC1
M11234_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT2_Q5
0.839 0.839
NFATC1
M05713_2.00
Homo sapiens
NTTTCCRYGGAAAN

NTTTCCRYGGAAAN
SELEX
Yin et al.(2017)
NFATC1_eDBD_Methyl-HT-SELEX_1
0.839 0.839
NFATC1
M05714_2.00
Homo sapiens
NTTTCCRYNNRYGGAAAN

NTTTCCRYNNRYGGAAAN
SELEX
Yin et al.(2017)
NFATC1_eDBD_Methyl-HT-SELEX_2
0.839 0.839
NFATC2
M02441_2.00
Homo sapiens
WNTTTCCRHN

NDYGGAAANW
PBM
Weirauch et al.(2014)
pTH9196
0.825 0.825
NFATC2
M05705_2.00
Homo sapiens
DTTTCCATGGAAAM

KTTTCCATGGAAAH
SELEX
Yin et al.(2017)
NFATC2_eDBD_HT-SELEX_1
0.825 0.825
NFATC2
M05706_2.00
Homo sapiens
NTTTCCRYNNRYGGAAAN

NTTTCCRYNNRYGGAAAN
SELEX
Yin et al.(2017)
NFATC2_eDBD_HT-SELEX_2
0.825 0.825
NFATC2
M09346_2.00
Homo sapiens
NWTTTTCCW

WGGAAAAWN
Misc
Kulakovskiy et al.(2013)
NFAC2_HUMAN.H11MO.0.B
0.825 0.825
Nfatc2
M09357_2.00
Mus musculus
NWTTTTCCW

WGGAAAAWN
Misc
Kulakovskiy et al.(2013)
NFAC2_MOUSE.H11MO.0.C
0.825 0.825
NFATC2
M11221_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT1_Q4
0.825 0.825
NFATC2
M11222_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT1_Q5
0.825 0.825
NFATC2
M11223_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$NFAT1_Q6
0.825 0.825
NFATC2
M08462_2.00
Homo sapiens
TTTTCCA

TGGAAAA
COMPILED
Mathelier et al.(2014)
MA0152.1
0.825 0.825
NFATC2
M05707_2.00
Homo sapiens
NTTTCCGCGGAAAN

NTTTCCGCGGAAAN
SELEX
Yin et al.(2017)
NFATC2_eDBD_Methyl-HT-SELEX_1
0.825 0.825
NFATC2
M05708_2.00
Homo sapiens
NTTTCCRYNNRYGGAAAN

NTTTCCRYNNRYGGAAAN
SELEX
Yin et al.(2017)
NFATC2_eDBD_Methyl-HT-SELEX_2
0.825 0.825
ENSTNIG00000018271
M02445_2.00
Tetraodon nigroviridis
DNDTTCCRNN

NNYGGAAHNH
PBM
Weirauch et al.(2014)
pTH9005
0.741 0.741
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M02440_2.00 Rel 51 210

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000264008 Rel 433 592
ENSP00000300659 Rel 433 592
ENSP00000331324 Rel 433 592
ENSP00000456120 Rel 418 577
ENSP00000456379 Rel 418 577
ENSP00000457441 Rel 51 119
ENSP00000460533 Rel 433 592

Links

Other Rel family TFs
Other Homo sapiens TFs

249 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action