run (Drosophila melanogaster)
Runt

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00853 (Runt) IPR013524 FBgn0003300 T319522_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including axon guidance; germ-band extension; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including ectoderm; ectoderm anlage; embryonic/larval nervous system; extended germ band embryo; and somatic precursor cell. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cleidocranial dysplasia; esophagus squamous cell carcinoma; and metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome. Orthologous to several human genes including RUNX2 (RUNX family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
run
M06444_2.00		 Drosophila melanogaster
WAACCGCAR
YTGCGGTTW		 B1H
Zhu et al.(2011)
run_Bgb_NBT_FBgn0003300		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
lz
M03964_2.00 		Drosophila melanogaster
HRACCGCAAHM
KDTTGCGGTYD		 SELEX
Nitta et al.(2015)
lz_1 		0.721 0.721
lz
M03965_2.00 		Drosophila melanogaster
HVACCRCARWAACCRCAV
BTGYGGTTWYTGYGGTBD		 SELEX
Nitta et al.(2015)
lz_2 		0.721 0.721
lz
M03966_2.00 		Drosophila melanogaster
WRACCRCAWTAACCRCAA
TTGYGGTTAWTGYGGTYW		 SELEX
Nitta et al.(2015)
lz_3 		0.721 0.721
lz
M03967_2.00 		Drosophila melanogaster
HRACCGCAAAACCRCAR
YTGYGGTTTTGCGGTYD		 SELEX
Nitta et al.(2015)
lz_4 		0.723 0.723
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0076971 Runt 107 236
FBpp0293135 Runt 107 235
FBpp0311837 Runt 107 236

Links

Other Runt family TFs
Other Drosophila melanogaster TFs

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187 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action