SP100 (Homo sapiens)

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01342 (SAND) IPR000770 ENSG00000067066 T321709_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
No TFs with similar DNA binding domains

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000264052 SAND 599 675
ENSP00000264052 Sox 696 753
ENSP00000264052 Sox 769 837
ENSP00000343023 SAND 599 675
ENSP00000386427 SAND 599 675
ENSP00000393679 SAND 1 61


Other SAND family TFs
Other Homo sapiens TFs

9 Related TFs

Name Species Gene ID Motif Evidence SR
SP100 Pan troglodytes ENSPTRG00000013012 N 0.994
ENSPPYG00000013255 Pongo abelii ENSPPYG00000013255 N 0.986
SP100 Gorilla gorilla ENSGGOG00000006712 N 0.985
ENSNLEG00000013741 Nomascus leucogenys ENSNLEG00000013741 N 0.985
ENSPANG00000000877 Papio anubis ENSPANG00000000877 N 0.971
ENSP00000343023 Macaca fascicularis ENSP00000343023 N 0.967
ENSCSAG00000006851 Chlorocebus sabaeus ENSCSAG00000006851 N 0.957
SP100 Callithrix jacchus ENSCJAG00000013324 N 0.947