| NCBI Gene Info:Enables chromatin DNA binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; nervous system development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytosol and nucleus. Part of heteromeric SMAD protein complex. Is expressed in several structures, including central nervous system; embryonic/larval muscle cell; germline cell; gut section; and mesoderm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; cervical cancer; ovarian cancer; and pancreatic cancer. Orthologous to several human genes including SMAD3 (SMAD family member 3). [provided by Alliance of Genome Resources, Apr 2022] |