| NCBI Gene Info:Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of dauer larval development; and regulation of pharyngeal pumping. Located in condensed chromosome; cytoplasm; and nucleus. Is expressed in several structures, including P1; P10; hermaphrodite distal tip cell; hypodermal cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including female reproductive organ cancer (multiple); hereditary hemorrhagic telangiectasia; juvenile polyposis syndrome; juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome; and seminoma. Orthologous to human SMAD4 (SMAD family member 4). [provided by Alliance of Genome Resources, Apr 2022] |