| NCBI Gene Info:Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of oviposition; and regulation of pharyngeal pumping. Acts upstream of or within determination of adult lifespan. Predicted to be active in nucleus. Is expressed in several structures, including body wall musculature; egg-laying apparatus; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome; NFIA-related disorder; and Sotos syndrome 2. Orthologous to several human genes including NFIA (nuclear factor I A); NFIB (nuclear factor I B); and NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Apr 2022] |