Tbp (Drosophila melanogaster)
TBP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00352 (TBP) IPR000814 FBgn0003687 T342470_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase III type 3 promoter sequence-specific DNA binding activity; and TFIIA-class transcription factor complex binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription, DNA-templated. Located in nucleus. Part of transcription factor TFIID complex and transcription factor TFIIIB complex. Is expressed in several structures, including reproductive system. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to several human genes including TBP (TATA-box binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbp
M00216_2.00 		Mus musculus
NWWWWAW
WTWWWWN		 PBM
Badis et al.(2009)
Tbp_pr781 		0.898 0.898
TBP
M08231_2.00 		Homo sapiens
YATTTGCATD
HATGCAAATR		 ChIP-seq
Contrino et al.(2012)
Mv129 		0.898 0.898
TBP
M09432_2.00 		Homo sapiens
MTATAWAWRS
SYWTWTATAK		 Misc
Kulakovskiy et al.(2013)
TBP_HUMAN.H11MO.0.A 		0.898 0.898
Tbp
M09433_2.00 		Mus musculus
VTATAAAARS
SYTTTTATAB		 Misc
Kulakovskiy et al.(2013)
TBP_MOUSE.H11MO.0.A 		0.898 0.898
TBP
M11388_2.00 		Homo sapiens
VTATAWAWRVVNNNN
NNNNBBYWTWTATAB		 Transfac
Matys et al.(2006)
V$TATA_01 		0.898 0.898
TBP
M11389_2.00 		Homo sapiens
NCYWTAAAAD
HTTTTAWRGN		 Transfac
Matys et al.(2006)
V$TATA_C 		0.898 0.898
TBP
M11390_2.00 		Homo sapiens
KATAAATW
WATTTATM		 Transfac
Matys et al.(2006)
V$TBP_01 		0.898 0.898
TBP
M11391_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBP_Q6_01 		0.898 0.898
TBP
M11392_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBP_Q6 		0.898 0.898
TBP
M11491_2.00 		Homo sapiens
VTATAWAWRVVNNNN
NNNNBBYWTWTATAB		 Unknown
Mathelier et al.(2014)
MA0108.2 		0.898 0.898
SPT15
M01567_2.00 		Saccharomyces cerevisiae
NNDWDAW
WTHWHNN		 PBM
Zhu et al.(2009)
Spt15 		0.814 0.814
SPT15
M08609_2.00 		Saccharomyces cerevisiae
NNBBHWTATATATWNCNNDNB
VNHNNGNWATATATAWDVVNN		 Misc
DeBoer et al.(2011)
YER148W_798 		0.814 0.814
SPT15
M11393_2.00 		Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$TBP_Q6 		0.814 0.814
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0071596 TBP 176 258
FBpp0071596 TBP 266 349

Links

Other TBP family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

762 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action