IRF4 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000137265 T244081_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF4
M03334_2.00		 Homo sapiens
HCGAAACCGAAACYW
WRGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF4_1		 (Direct) (Direct)
IRF4
M05539_2.00		 Homo sapiens
NYGAAACYGAAACYN
NRGTTTCRGTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX		 (Direct) (Direct)
IRF4
M05540_2.00		 Homo sapiens
NYGAAASYGAWASHN
NDSTWTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX		 (Direct) (Direct)
IRF4
M07978_2.00		 Homo sapiens
DNDVNNGWWVTGAVWVWN
NWBWBTCABWWCNNBHNH		 ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha		 (Direct) (Direct)
IRF4
M09235_2.00		 Homo sapiens
NDWDRRGGAASTGARAVH
DBTYTCASTTCCYYHWHN		 Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A		 (Direct) (Direct)
IRF4
M09595_2.00		 Homo sapiens
HNYGAAASYD
HRSTTTCRND		 Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465		 (Direct) (Direct)
IRF4
M10885_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_07		 (Direct) (Direct)
IRF4
M10886_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_08		 (Direct) (Direct)
IRF4
M10887_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5_01		 (Direct) (Direct)
IRF4
M10888_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5		 (Direct) (Direct)
IRF4
M10889_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf4
M00175_2.00 		Mus musculus
NNNYGAWASN
NSTWTCRNNN		 PBM
Badis et al.(2009)
Irf4_3476 		0.990 0.990
Irf4
M09243_2.00 		Mus musculus
NDAWVVRGAASTGARAVH
DBTYTCASTTCYBBWTHN		 Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A 		0.990 0.990
IRF8
M03335_2.00 		Homo sapiens
HCGAAACYGAAACY
RGTTTCRGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_1 		0.810 0.810
IRF8
M03336_2.00 		Homo sapiens
HCGAAACCGAAACT
AGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_2 		0.810 0.810
IRF8
M05541_2.00 		Homo sapiens
NYGAAASYGAAASHN
NDSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX 		0.810 0.810
IRF8
M05543_2.00 		Homo sapiens
NCGAAACYGAAACYN
NRGTTTCRGTTTCGN		 SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX 		0.810 0.810
IRF8
M09236_2.00 		Homo sapiens
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B 		0.810 0.810
IRF8
M10890_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ICSBP_Q6 		0.810 0.810
IRF8
M10891_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF8_Q6 		0.810 0.810
IRF8
M05542_2.00 		Homo sapiens
NYGAAASYGAAASYN
NRSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX 		0.810 0.810
IRF8
M05544_2.00 		Homo sapiens
NYGAAASYGAAACYD
HRGTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX 		0.810 0.810
Irf8
M09246_2.00 		Mus musculus
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A 		0.790 0.790
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000370343 IRF 23 128
ENSP00000436094 IRF 23 128

Links

Other IRF family TFs
Other Homo sapiens TFs

157 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Aan_R009222 Calypte anna Aan_R009222 I 0.808
Aan_R012662 Calypte anna Aan_R012662 I 0.990
Afo_R011419 Aptenodytes forsteri Afo_R011419 I 0.808
Afo_R014746 Aptenodytes forsteri Afo_R014746 I 0.990
Alligator_sinensis_CCG008430.1 Alligator sinensis Alligator_sinensis_CCG008430.1 I 0.817
Alligator_sinensis_CCG015622.1 Alligator sinensis Alligator_sinensis_CCG015622.1 I 0.990
Brh_R000433 Buceros rhinoceros Brh_R000433 I 0.981
Brh_R009589 Buceros rhinoceros Brh_R009589 I 0.808
Cmyd_10011521 Chelonia mydas Cmyd_10011521 I 0.990
Cmyd_10021085 Chelonia mydas Cmyd_10021085 I 0.827
IRF8 Anolis carolinensis ENSACAG00000005409 I 0.798
IRF4 Anolis carolinensis ENSACAG00000017711 I 0.971
ENSAMEG00000005976 Ailuropoda melanoleuca ENSAMEG00000005976 I 1.000
ENSAMEG00000018268 Ailuropoda melanoleuca ENSAMEG00000018268 I 0.808
ENSAMXG00000002697 Astyanax mexicanus ENSAMXG00000002697 I 0.752
ENSAMXG00000003452 Astyanax mexicanus ENSAMXG00000003452 I 0.752
ENSAMXG00000004911 Astyanax mexicanus ENSAMXG00000004911 I
ENSAMXG00000006093 Astyanax mexicanus ENSAMXG00000006093 I 0.924
ENSAMXG00000012775 Astyanax mexicanus ENSAMXG00000012775 I 0.848
ENSAMXG00000016370 Astyanax mexicanus ENSAMXG00000016370 I 0.914
ENSAPLG00000014646 Anas platyrhynchos ENSAPLG00000014646 I 0.990
IRF4 Bos taurus ENSBTAG00000002929 I 1.000
IRF8 Bos taurus ENSBTAG00000017824 I 0.790
IRF8 Canis familiaris ENSCAFG00000019919 I 0.808
IRF8 Callithrix jacchus ENSCJAG00000017331 I 0.798
IRF4 Callithrix jacchus ENSCJAG00000019524 I 1.000
IRF4 Cavia porcellus ENSCPOG00000003562 I 1.000
ENSCPOG00000027266 Cavia porcellus ENSCPOG00000027266 I 0.808
ENSCSAG00000003142 Chlorocebus sabaeus ENSCSAG00000003142 I 0.800
ENSCSAG00000007164 Chlorocebus sabaeus ENSCSAG00000007164 I 1.000
irf4a Danio rerio ENSDARG00000006560 I 0.914
irf9 Danio rerio ENSDARG00000016457 I 0.702
irf10 Danio rerio ENSDARG00000027658 I 0.771
irf4b Danio rerio ENSDARG00000055374 I 0.933
irf8 Danio rerio ENSDARG00000056407 I 0.743
IRF8 Dasypus novemcinctus ENSDNOG00000038898 I 0.808
Irf4 Dipodomys ordii ENSDORG00000014895 I 1.000
IRF4 Equus caballus ENSECAG00000016808 I 1.000
IRF8 Erinaceus europaeus ENSEEUG00000002644 I 0.762
IRF4 Erinaceus europaeus ENSEEUG00000007703 I 0.933
IRF4 Echinops telfairi ENSETEG00000018472 I 1.000
ENSFALG00000005506 Ficedula albicollis ENSFALG00000005506 I 0.743
ENSFALG00000006647 Ficedula albicollis ENSFALG00000006647 I 0.817
ENSFALG00000013071 Ficedula albicollis ENSFALG00000013071 I 0.990
IRF8 Felis catus ENSFCAG00000007615 I 0.808
IRF4 Felis catus ENSFCAG00000022941 I 1.000
IRF8 Homo sapiens ENSG00000140968 D 0.846
irf4b Gasterosteus aculeatus ENSGACG00000004966 I 0.933
irf10 Gasterosteus aculeatus ENSGACG00000015123 I 0.733
irf8 Gasterosteus aculeatus ENSGACG00000015958 I 0.733
irf4a Gasterosteus aculeatus ENSGACG00000016461 I 0.886
IRF8 Gallus gallus ENSGALG00000005757 I 0.800
ENSGALG00000006448 Gallus gallus ENSGALG00000006448 I 0.733
ENSGALG00000012830 Gallus gallus ENSGALG00000012830 I 0.990
IRF4 Gorilla gorilla ENSGGOG00000012342 I 1.000
IRF8 Gorilla gorilla ENSGGOG00000028251 I 0.800
ENSGMOG00000003945 Gadus morhua ENSGMOG00000003945 I 0.740
ENSGMOG00000005047 Gadus morhua ENSGMOG00000005047 I 0.886
ENSGMOG00000016994 Gadus morhua ENSGMOG00000016994 I 0.924
ENSLACG00000004633 Latimeria chalumnae ENSLACG00000004633 I 0.721
ENSLACG00000005859 Latimeria chalumnae ENSLACG00000005859 I 0.790
ENSLACG00000007228 Latimeria chalumnae ENSLACG00000007228 I 0.790
IRF8 Loxodonta africana ENSLAFG00000010973 I 0.800
IRF4 Loxodonta africana ENSLAFG00000017235 I 1.000
ENSLOCG00000001013 Lepisosteus oculatus ENSLOCG00000001013 I 0.800
ENSLOCG00000003532 Lepisosteus oculatus ENSLOCG00000003532 I 0.781
ENSLOCG00000013008 Lepisosteus oculatus ENSLOCG00000013008 I 0.962
ENSMEUG00000002440 Macropus eugenii ENSMEUG00000002440 I 0.990
IRF8 Myotis lucifugus ENSMLUG00000005109 I 0.808
IRF4 Myotis lucifugus ENSMLUG00000010058 I 1.000
IRF8 Macaca mulatta ENSMMUG00000008125 I 0.800
IRF4 Macaca mulatta ENSMMUG00000018513 I 1.000
IRF8 Monodelphis domestica ENSMODG00000004572 I 0.817
IRF4 Monodelphis domestica ENSMODG00000008383 I 0.990
ENSMODG00000019483 Monodelphis domestica ENSMODG00000019483 I 0.705
ENSMPUG00000007848 Mustela putorius furo ENSMPUG00000007848 I 1.000
ENSMPUG00000008641 Mustela putorius furo ENSMPUG00000008641 I 0.810
Irf4 Mus musculus ENSMUSG00000021356 D 0.990
Irf8 Mus musculus ENSMUSG00000041515 D 0.790
ENSNLEG00000010631 Nomascus leucogenys ENSNLEG00000010631 I 1.000
ENSNLEG00000011429 Nomascus leucogenys ENSNLEG00000011429 I 0.800
IRF8 Ornithorhynchus anatinus ENSOANG00000003741 I 0.790
ENSOARG00000003822 Ovis aries ENSOARG00000003822 I 1.000
ENSOARG00000011513 Ovis aries ENSOARG00000011513 I 0.790
IRF8 Oryctolagus cuniculus ENSOCUG00000000536 I 0.808
IRF4 Oryctolagus cuniculus ENSOCUG00000009374 I 0.981
IRF8 Otolemur garnettii ENSOGAG00000009262 I 0.790
IRF4 Otolemur garnettii ENSOGAG00000014574 I 1.000
ENSONIG00000005631 Oreochromis niloticus ENSONIG00000005631 I 0.733
ENSONIG00000006398 Oreochromis niloticus ENSONIG00000006398 I 0.933
ENSONIG00000009637 Oreochromis niloticus ENSONIG00000009637 I 0.895
IRF8 Ochotona princeps ENSOPRG00000002139 I 0.790
IRF4 Ochotona princeps ENSOPRG00000012683 I 1.000
irf4b Oryzias latipes ENSORLG00000012712 I 0.943
irf4a Oryzias latipes ENSORLG00000017242 I 0.914
irf8 Oryzias latipes ENSORLG00000018216 I 0.762
ENSP00000268638 Macaca fascicularis ENSP00000268638 I 0.800
ENSP00000268638-D1 Bos grunniens ENSP00000268638-D1 I 0.790
ENSP00000370343-D1 Bos grunniens ENSP00000370343-D1 I 1.000
ENSPANG00000024770 Papio anubis ENSPANG00000024770 I 0.800
IRF8 Procavia capensis ENSPCAG00000004460 I 0.800
ENSPFOG00000000657 Poecilia formosa ENSPFOG00000000657 I 0.933
ENSPFOG00000015506 Poecilia formosa ENSPFOG00000015506 I 0.895
ENSPFOG00000017639 Poecilia formosa ENSPFOG00000017639 I 0.743
ENSPPYG00000007620 Pongo abelii ENSPPYG00000007620 I 0.800
ENSPPYG00000016161 Pongo abelii ENSPPYG00000016161 I 1.000
ENSPSIG00000011619 Pelodiscus sinensis ENSPSIG00000011619 I 1.000
ENSPSIG00000011788 Pelodiscus sinensis ENSPSIG00000011788 I 0.827
IRF8 Pan troglodytes ENSPTRG00000008435 I 0.800
IRF4 Pan troglodytes ENSPTRG00000017656 I 1.000
IRF8 Pteropus vampyrus ENSPVAG00000003758 I 0.808
IRF4 Pteropus vampyrus ENSPVAG00000005078 I 1.000
Irf8 Rattus norvegicus ENSRNOG00000017869 I 0.790
Irf4 Rattus norvegicus ENSRNOG00000061070 I 0.990
ENSSHAG00000006901 Sarcophilus harrisii ENSSHAG00000006901 I 0.817
ENSSHAG00000012864 Sarcophilus harrisii ENSSHAG00000012864 I
ENSSHAG00000015592 Sarcophilus harrisii ENSSHAG00000015592 I 0.990
ENSSSCG00000023184 Sus scrofa ENSSSCG00000023184 I
ENSSTOG00000011470 Ictidomys tridecemlineatus ENSSTOG00000011470 I 1.000
ENSSTOG00000028363 Ictidomys tridecemlineatus ENSSTOG00000028363 I 0.798
IRF4 Tupaia belangeri ENSTBEG00000012240 I 1.000
IRF8 Tupaia belangeri ENSTBEG00000013828 I 0.779
IRF4 Taeniopygia guttata ENSTGUG00000002144 I 0.990
ENSTGUG00000006609 Taeniopygia guttata ENSTGUG00000006609 I 0.743
irf4a Tetraodon nigroviridis ENSTNIG00000005370 I 0.895
irf4b Tetraodon nigroviridis ENSTNIG00000008222 I 0.943
irf8 Tetraodon nigroviridis ENSTNIG00000009283 I 0.724
irf10 Tetraodon nigroviridis ENSTNIG00000012613 I 0.724
irf4b Takifugu rubripes ENSTRUG00000002946 I 0.952
irf4a Takifugu rubripes ENSTRUG00000011568 I 0.886
irf8 Takifugu rubripes ENSTRUG00000018213 I 0.752
IRF4 Tursiops truncatus ENSTTRG00000001849 I 0.990
ENSXMAG00000003082 Xiphophorus maculatus ENSXMAG00000003082 I 0.760
ENSXMAG00000006246 Xiphophorus maculatus ENSXMAG00000006246 I 0.933
ENSXMAG00000017015 Xiphophorus maculatus ENSXMAG00000017015 I 0.895
Gfo_R000501 Geospiza fortis Gfo_R000501 I 0.798
Gfo_R003357 Geospiza fortis Gfo_R003357 I 0.990
Myotis_brandtii_Irf4_10020370 Myotis brandtii Myotis_brandtii_Irf4_10020370 I 0.962
Ogr04948 Ophisaurus gracilis Ogr04948 N
Ogr05775 Ophisaurus gracilis Ogr05775 I 0.971
Ogr08841 Ophisaurus gracilis Ogr08841 I 0.775
Pvit_05673 Pogona vitticeps Pvit_05673 I 0.981
Pvit_16863 Pogona vitticeps Pvit_16863 I 0.800
Tal_R007108 Tyto alba Tal_R007108 I 0.808
irf10 Xenopus tropicalis XB-GENE-1033046 I
irf8.L Xenopus laevis XB-GENE-985949 I 0.790
irf4 Xenopus tropicalis XB-GENE-988321 I 0.962