NFATC1 (Homo sapiens)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00554 (RHD_DNA_bind) IPR011539 ENSG00000131196 T317173_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFATC1
M02747_2.00		 Homo sapiens
DTTCCRYGGAA
TTCCRYGGAAH		 SELEX
Jolma et al.(2010)
NFATc1_dimer		 (Direct) (Direct)
NFATC1
M02748_2.00		 Homo sapiens
GGAANDTTCC
GGAAHNTTCC		 SELEX
Jolma et al.(2010)
NFATc1_dimer_type2		 (Direct) (Direct)
NFATC1
M02749_2.00		 Homo sapiens
WDTTTCCAY
RTGGAAAHW		 SELEX
Jolma et al.(2010)
NFATc1_monomer		 (Direct) (Direct)
NFATC1
M03449_2.00		 Homo sapiens
HKGRAAADDNWBTTTCCAYN
NRTGGAAAVWNHHTTTYCMD		 SELEX
Jolma et al.(2013)
NFATC1_1		 (Direct) (Direct)
NFATC1
M03450_2.00		 Homo sapiens
TTTCCAYWRYGGAAA
TTTCCRYWRTGGAAA		 SELEX
Jolma et al.(2013)
NFATC1_2		 (Direct) (Direct)
NFATC1
M03451_2.00		 Homo sapiens
NTTTCCATGGAAAN
NTTTCCATGGAAAN		 SELEX
Jolma et al.(2013)
NFATC1_3		 (Direct) (Direct)
NFATC1
M05711_2.00		 Homo sapiens
NTTTCCATGGAAAN
NTTTCCATGGAAAN		 SELEX
Yin et al.(2017)
NFATC1_eDBD_HT-SELEX_1		 (Direct) (Direct)
NFATC1
M05712_2.00		 Homo sapiens
NTTTCCRYNNRYGGAAAN
NTTTCCRYNNRYGGAAAN		 SELEX
Yin et al.(2017)
NFATC1_eDBD_HT-SELEX_2		 (Direct) (Direct)
NFATC1
M05713_2.00		 Homo sapiens
NTTTCCRYGGAAAN
NTTTCCRYGGAAAN		 SELEX
Yin et al.(2017)
NFATC1_eDBD_Methyl-HT-SELEX_1		 (Direct) (Direct)
NFATC1
M05714_2.00		 Homo sapiens
NTTTCCRYNNRYGGAAAN
NTTTCCRYNNRYGGAAAN		 SELEX
Yin et al.(2017)
NFATC1_eDBD_Methyl-HT-SELEX_2		 (Direct) (Direct)
NFATC1
M09349_2.00		 Homo sapiens
HBYHWBWBTTTCCWB
VWGGAAAVWVWDRVD		 Misc
Kulakovskiy et al.(2013)
NFAC1_HUMAN.H11MO.0.B		 (Direct) (Direct)
NFATC1
M09625_2.00		 Homo sapiens
WBTTTCCAYY
RRTGGAAAVW		 Misc
Heinz et al.(2010)
Jurkat-NFATC1_Jolma_et_al.		 (Direct) (Direct)
NFATC1
M11232_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT2_Q4		 (Direct) (Direct)
NFATC1
M11233_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT2_Q5_01		 (Direct) (Direct)
NFATC1
M11234_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT2_Q5		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NFATC1
M02444_2.00 		Monodelphis domestica
NNDTTCCDNN
NNHGGAAHNN		 PBM
Weirauch et al.(2014)
pTH8401 		0.944 0.944
Nfatc1
M09360_2.00 		Mus musculus
KABTCANWBTTTCCW
WGGAAAVWNTGAVTM		 Misc
Kulakovskiy et al.(2013)
NFAC1_MOUSE.H11MO.0.A 		0.910 0.910
NFATC1
M02443_2.00 		Meleagris gallopavo
NNTTTCCRNN
NNYGGAAANN		 PBM
Weirauch et al.(2014)
pTH8315 		0.916 0.916
nfatc1
M02446_2.00 		Xenopus tropicalis
NNTTTCCRNN
NNYGGAAANN		 PBM
Weirauch et al.(2014)
pTH8557 		0.895 0.895
NFATC3
M02440_2.00 		Homo sapiens
DNTTTCCRNN
NNYGGAAANH		 PBM
Weirauch et al.(2014)
pTH9192 		0.839 0.839
NFATC3
M05693_2.00 		Homo sapiens
WNTTTCCRYN
NRYGGAAANW		 SELEX
Yin et al.(2017)
NFATC3_eDBD_HT-SELEX_1 		0.839 0.839
NFATC3
M05694_2.00 		Homo sapiens
NTTTCCATGGAAAN
NTTTCCATGGAAAN		 SELEX
Yin et al.(2017)
NFATC3_eDBD_HT-SELEX_2 		0.860 0.860
NFATC3
M05695_2.00 		Homo sapiens
DYGGAAANNNNNNNTTTCCRH
DYGGAAANNNNNNNTTTCCRH		 SELEX
Yin et al.(2017)
NFATC3_eDBD_HT-SELEX_3 		0.839 0.839
NFATC3
M09343_2.00 		Homo sapiens
RDTTTTCCA
TGGAAAAHY		 Misc
Kulakovskiy et al.(2013)
NFAC3_HUMAN.H11MO.0.B 		0.839 0.839
Nfatc3
M09359_2.00 		Mus musculus
RDTTTTCCA
TGGAAAAHY		 Misc
Kulakovskiy et al.(2013)
NFAC3_MOUSE.H11MO.0.B 		0.839 0.839
NFATC3
M11217_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT4_Q3 		0.839 0.839
NFATC3
M11218_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT4_Q5 		0.839 0.839
NFATC3
M05696_2.00 		Homo sapiens
WNTTTCCRYN
NRYGGAAANW		 SELEX
Yin et al.(2017)
NFATC3_eDBD_Methyl-HT-SELEX_1 		0.860 0.860
NFATC3
M05697_2.00 		Homo sapiens
NTTTCCRYGGAAAN
NTTTCCRYGGAAAN		 SELEX
Yin et al.(2017)
NFATC3_eDBD_Methyl-HT-SELEX_2 		0.839 0.839
NFATC3
M05698_2.00 		Homo sapiens
RYGGAAANHNNNDNTTTCCRY
RYGGAAANHNNNDNTTTCCRY		 SELEX
Yin et al.(2017)
NFATC3_eDBD_Methyl-HT-SELEX_3 		0.839 0.839
Nfatc2
M09357_2.00 		Mus musculus
NWTTTTCCW
WGGAAAAWN		 Misc
Kulakovskiy et al.(2013)
NFAC2_MOUSE.H11MO.0.C 		0.830 0.830
NFATC2
M02441_2.00 		Homo sapiens
WNTTTCCRHN
NDYGGAAANW		 PBM
Weirauch et al.(2014)
pTH9196 		0.810 0.810
NFATC2
M05705_2.00 		Homo sapiens
DTTTCCATGGAAAM
KTTTCCATGGAAAH		 SELEX
Yin et al.(2017)
NFATC2_eDBD_HT-SELEX_1 		0.810 0.810
NFATC2
M05706_2.00 		Homo sapiens
NTTTCCRYNNRYGGAAAN
NTTTCCRYNNRYGGAAAN		 SELEX
Yin et al.(2017)
NFATC2_eDBD_HT-SELEX_2 		0.810 0.810
NFATC2
M09346_2.00 		Homo sapiens
NWTTTTCCW
WGGAAAAWN		 Misc
Kulakovskiy et al.(2013)
NFAC2_HUMAN.H11MO.0.B 		0.810 0.810
NFATC2
M11221_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT1_Q4 		0.810 0.810
NFATC2
M11222_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT1_Q5 		0.810 0.810
NFATC2
M11223_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT1_Q6 		0.810 0.810
NFATC2
M08462_2.00 		Homo sapiens
TTTTCCA
TGGAAAA		 COMPILED
Mathelier et al.(2014)
MA0152.1 		0.810 0.810
NFATC2
M05707_2.00 		Homo sapiens
NTTTCCGCGGAAAN
NTTTCCGCGGAAAN		 SELEX
Yin et al.(2017)
NFATC2_eDBD_Methyl-HT-SELEX_1 		0.810 0.810
NFATC2
M05708_2.00 		Homo sapiens
NTTTCCRYNNRYGGAAAN
NTTTCCRYNNRYGGAAAN		 SELEX
Yin et al.(2017)
NFATC2_eDBD_Methyl-HT-SELEX_2 		0.810 0.810
NFATC4
M01306_2.00 		Homo sapiens
NNNWWWVYRN
NYRBWWWNNN		 PBM
Lambert et al.(2019)
pTH9347 		0.800 0.800
NFATC4
M05701_2.00 		Homo sapiens
DBTTTCCRYN
NRYGGAAAVH		 SELEX
Yin et al.(2017)
NFATC4_eDBD_HT-SELEX_1 		0.800 0.800
NFATC4
M05702_2.00 		Homo sapiens
NKTTCCATGGAAMV
BKTTCCATGGAAMN		 SELEX
Yin et al.(2017)
NFATC4_eDBD_HT-SELEX_2 		0.800 0.800
NFATC4
M09345_2.00 		Homo sapiens
HNDBTTTCCN
NGGAAAVHND		 Misc
Kulakovskiy et al.(2013)
NFAC4_HUMAN.H11MO.0.C 		0.790 0.790
Nfatc4
M09354_2.00 		Mus musculus
HNDBTTTCCN
NGGAAAVHND		 Misc
Kulakovskiy et al.(2013)
NFAC4_MOUSE.H11MO.0.C 		0.790 0.790
NFATC4
M11219_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT3_Q3_01 		0.790 0.790
NFATC4
M11220_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NFAT3_Q3 		0.790 0.790
NFATC4
M05703_2.00 		Homo sapiens
DNTTTCCRYN
NRYGGAAANH		 SELEX
Yin et al.(2017)
NFATC4_eDBD_Methyl-HT-SELEX_1 		0.790 0.790
NFATC4
M05704_2.00 		Homo sapiens
NKTTCCRYGGAAMN
NKTTCCRYGGAAMN		 SELEX
Yin et al.(2017)
NFATC4_eDBD_Methyl-HT-SELEX_2 		0.790 0.790
ENSTNIG00000018271
M02445_2.00 		Tetraodon nigroviridis
DNDTTCCRNN
NNYGGAAHNH		 PBM
Weirauch et al.(2014)
pTH9005 		0.755 0.755
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000253506 Rel 428 588
ENSP00000316553 Rel 415 575
ENSP00000327850 Rel 415 575
ENSP00000380892 Rel 1 116
ENSP00000389377 Rel 428 588
ENSP00000439992 Rel 1 116
ENSP00000442435 Rel 428 588
ENSP00000466194 Rel 428 588
ENSP00000466489 Rel 415 575
ENSP00000467181 Rel 415 575
ENSP00000468111 Rel 428 588

Links

Other Rel family TFs
Other Homo sapiens TFs

247 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ANCCEY_01929 Ancylostoma ceylanicum ANCCEY_01929 N
ANCDUO_19967 Ancylostoma duodenale ANCDUO_19967 N
ANCDUO_21567 Ancylostoma duodenale ANCDUO_21567 N
ASIM_0001677501 Anisakis simplex ASIM_0001677501 N
ASU_12719 Ascaris suum ASU_12719 N
Bm3899 Brugia malayi Bm3899 N
BTMF_0001429501 Brugia timori BTMF_0001429501 N
BXY_0574800 Bursaphelenchus xylophilus BXY_0574800 N
CBG02231 Caenorhabditis briggsae CBG02231 N
CBN00758 Caenorhabditis brenneri CBN00758 N
CBN06012 Caenorhabditis brenneri CBN06012 N
CJA12147 Caenorhabditis japonica CJA12147 N
CRE29609 Caenorhabditis remanei CRE29609 N
DICVIV_00304 Dictyocaulus viviparus DICVIV_00304 N
DME_0000214701 Dracunculus medinensis DME_0000214701 N
EVEC_0000982901 Enterobius vermicularis EVEC_0000982901 N
HPBE_0001103101 Heligmosomoides bakeri HPBE_0001103101 N
HPLM_0000720101 Haemonchus placei HPLM_0000720101 N
L596_g21063 Steinernema carpocapsae L596_g21063 N
L889_g15246 Steinernema feltiae L889_g15246 N
L893_g5132 Steinernema glaseri L893_g5132 N
L898_g4344 Steinernema monticolum L898_g4344 N
LOAG_18157 Loa loa LOAG_18157 N
MhA1_Contig659.frz3.gene12 Meloidogyne hapla MhA1_Contig659.frz3.gene12 N
Minc00757 Meloidogyne incognita Minc00757 N
Minc01466 Meloidogyne incognita Minc01466 N
nAv.1.0.1.g02876 Acanthocheilonema viteae nAv.1.0.1.g02876 N
nDi.2.2.2.g08539 Dirofilaria immitis nDi.2.2.2.g08539 N
NECAME_05919 Necator americanus NECAME_05919 N
nLs.2.1.2.g02844 Litomosoides sigmodontis nLs.2.1.2.g02844 N
PEQ_0000361701 Parascaris equorum PEQ_0000361701 N
PTRK_0001052400 Parastrongyloides trichosuri PTRK_0001052400 N
SPAL_0000096300 Strongyloides papillosus SPAL_0000096300 N
SSTP_0000137400 Strongyloides stercoralis SSTP_0000137400 N
SVE_0382900 Strongyloides venezuelensis SVE_0382900 N
TCLT_0000822701 Thelazia callipaeda TCLT_0000822701 N
TCNE_0001786701 Toxocara canis TCNE_0001786701 N
TELCIR_17986 Teladorsagia circumcincta TELCIR_17986 N
TELCIR_19586 Teladorsagia circumcincta TELCIR_19586 N
TELCIR_20778 Teladorsagia circumcincta TELCIR_20778 N
tag-68 Caenorhabditis elegans WBGene00006445 N
WUBG_00492 Wuchereria bancrofti WUBG_00492 N