CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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nhr-141
(
Caenorhabditis elegans
)
Nuclear receptor
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00105 (zf-C4)
IPR001628
WBGene00017787
T306340_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in anatomical structure development; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
nhr-204
M00704_2.00
Caenorhabditis elegans
NDNTGRTMHN
NDKAYCANHN
PBM
Narasimhan et al.(2015)
pTH10028
0.892
0.500
nhr-168
M00699_2.00
Caenorhabditis elegans
NNNHHCRNHN
NDNYGDDNNN
PBM
Narasimhan et al.(2015)
pTH10013
0.891
0.729
CBG26996_CONSTRUCT
M01300_2.00
PBM CONSTRUCTS
NNNNTGRWMN
NKWYCANNNN
PBM
Lambert et al.(2019)
pTH11460
0.881
0.529
For this family, TFs with SR scores >
0.745
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
F25E5.6.1
Nuclear receptor
14
85
TECSVCGKKATGYHYDVPSCNGCKTFFRRICISEKTMQCQGVGDCFDLTKRIAPVKCRACRFEKCVLKGMNP
F25E5.6.2
Nuclear receptor
14
85
TECSVCGKKATGYHYDVPSCNGCKTFFRRICISEKTMQCQGVGDCFDLTKRIAPVKCRACRFEKCVLKGMNP
Links
Other
Nuclear receptor
family TFs
Other
Caenorhabditis elegans
TFs
41 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy