nhr-168 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00008221 T306261_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in anatomical structure development; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in seam cell. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-168
M00699_2.00		 Caenorhabditis elegans
NNNHHCRNHN
NDNYGDDNNN		 PBM
Narasimhan et al.(2015)
pTH10013		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.745 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00699_2.00 Nuclear receptor 48 119

DNA Binding Domains

Protein ID Domain From To Sequence
C50B6.8a Nuclear receptor 48 119
C50B6.8b.1 Nuclear receptor 48 119
C50B6.8b.2 Nuclear receptor 48 119

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

10 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE27544 Caenorhabditis remanei CRE27544 I 0.989
CRE09109 Caenorhabditis remanei CRE09109 I 0.978
nhr-60 Caenorhabditis elegans WBGene00003650 I 0.976
CBN20373 Caenorhabditis brenneri CBN20373 I 0.946
CBG22907 Caenorhabditis briggsae CBG22907 I 0.922
nhr-141 Caenorhabditis elegans WBGene00017787 I 0.891
nhr-116 Caenorhabditis elegans WBGene00003706 I 0.854
CJA12037 Caenorhabditis japonica CJA12037 I 0.794
CJA16466 Caenorhabditis japonica CJA16466 I 0.768