IRF8 (Homo sapiens)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSG00000140968 T244082_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
IRF8
M03335_2.00		 Homo sapiens
HCGAAACYGAAACY
RGTTTCRGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_1		 (Direct) (Direct)
IRF8
M03336_2.00		 Homo sapiens
HCGAAACCGAAACT
AGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF8_2		 (Direct) (Direct)
IRF8
M05541_2.00		 Homo sapiens
NYGAAASYGAAASHN
NDSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_HT-SELEX		 (Direct) (Direct)
IRF8
M05542_2.00		 Homo sapiens
NYGAAASYGAAASYN
NRSTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
IRF8
M05543_2.00		 Homo sapiens
NCGAAACYGAAACYN
NRGTTTCRGTTTCGN		 SELEX
Yin et al.(2017)
IRF8_FL_HT-SELEX		 (Direct) (Direct)
IRF8
M05544_2.00		 Homo sapiens
NYGAAASYGAAACYD
HRGTTTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF8_FL_Methyl-HT-SELEX		 (Direct) (Direct)
IRF8
M09236_2.00		 Homo sapiens
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_HUMAN.H11MO.0.B		 (Direct) (Direct)
IRF8
M10890_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ICSBP_Q6		 (Direct) (Direct)
IRF8
M10891_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF8_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf8
M09246_2.00 		Mus musculus
NDDDRRGGAASTGAAASYNN
NNRSTTTCASTTCCYYHHHN		 Misc
Kulakovskiy et al.(2013)
IRF8_MOUSE.H11MO.0.A 		0.949 0.949
Irf4
M00175_2.00 		Mus musculus
NNNYGAWASN
NSTWTCRNNN		 PBM
Badis et al.(2009)
Irf4_3476 		0.817 0.817
IRF4
M03334_2.00 		Homo sapiens
HCGAAACCGAAACYW
WRGTTTCGGTTTCGD		 SELEX
Jolma et al.(2013)
IRF4_1 		0.817 0.817
IRF4
M05539_2.00 		Homo sapiens
NYGAAACYGAAACYN
NRGTTTCRGTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_HT-SELEX 		0.817 0.817
IRF4
M07978_2.00 		Homo sapiens
DNDVNNGWWVTGAVWVWN
NWBWBTCABWWCNNBHNH		 ChIP-seq
Gerstein et al.(2012)
GM12878_IRF4_HudsonAlpha 		0.817 0.817
IRF4
M09235_2.00 		Homo sapiens
NDWDRRGGAASTGARAVH
DBTYTCASTTCCYYHWHN		 Misc
Kulakovskiy et al.(2013)
IRF4_HUMAN.H11MO.0.A 		0.846 0.846
Irf4
M09243_2.00 		Mus musculus
NDAWVVRGAASTGARAVH
DBTYTCASTTCYBBWTHN		 Misc
Kulakovskiy et al.(2013)
IRF4_MOUSE.H11MO.0.A 		0.846 0.846
IRF4
M09595_2.00 		Homo sapiens
HNYGAAASYD
HRSTTTCRND		 Misc
Heinz et al.(2010)
GM12878-IRF4_GSE32465 		0.846 0.846
IRF4
M10885_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_07 		0.846 0.846
IRF4
M10886_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_08 		0.846 0.846
IRF4
M10887_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5_01 		0.817 0.817
IRF4
M10888_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q5 		0.817 0.817
IRF4
M10889_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF4_Q6 		0.817 0.817
IRF4
M05540_2.00 		Homo sapiens
NYGAAASYGAWASHN
NDSTWTCRSTTTCRN		 SELEX
Yin et al.(2017)
IRF4_FL_Methyl-HT-SELEX 		0.817 0.817
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000268638 IRF 9 113
ENSP00000455048 IRF 1 56
ENSP00000455784 IRF 9 113
ENSP00000455816 IRF 9 47
ENSP00000456992 IRF 9 113
ENSP00000458047 IRF 9 113

Links

Other IRF family TFs
Other Homo sapiens TFs

166 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
A1Q1_02097 Trichosporon asahii A1Q1_02097 N
E5Q_04582 Mixia osmundae E5Q_04582 N
estExt_fgeneshMC_pg.C_10568 Mucor circinelloides estExt_fgeneshMC_pg.C_10568 I
estExt_Genewise1.C_80340 Mucor circinelloides estExt_Genewise1.C_80340 I
GLOINDRAFT_221110 Rhizophagus irregularis GLOINDRAFT_221110 I
GLOINDRAFT_24118 Rhizophagus irregularis GLOINDRAFT_24118 I
GLOINDRAFT_58638 Rhizophagus irregularis GLOINDRAFT_58638 I
gw1.15.181.1 Phycomyces blakesleeanus gw1.15.181.1 I
gw1.23.155.1 Phycomyces blakesleeanus gw1.23.155.1 I
gw1.25.121.1 Phycomyces blakesleeanus gw1.25.121.1 I
gw1.6.924.1 Mucor circinelloides gw1.6.924.1 N
gw1.73.24.1 Phycomyces blakesleeanus gw1.73.24.1 I
PHACADRAFT_73403 Phanerochaete carnosa PHACADRAFT_73403 N
RO3G_01826 Rhizopus oryzae RO3G_01826 I
RO3G_05801 Rhizopus oryzae RO3G_05801 D
RO3G_13834 Rhizopus oryzae RO3G_13834 I