RUNX2 (Homo sapiens)
Runt

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00853 (Runt) IPR013524 ENSG00000124813 T319383_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RUNX2
M03468_2.00		 Homo sapiens
HRACCGCAAACCRCRD
HYGYGGTTTGCGGTYD		 SELEX
Jolma et al.(2013)
RUNX2_1		 (Direct) (Direct)
RUNX2
M03469_2.00		 Homo sapiens
HRACCRCADWWACCRCAD
HTGYGGTWWHTGYGGTYD		 SELEX
Jolma et al.(2013)
RUNX2_2		 (Direct) (Direct)
RUNX2
M03470_2.00		 Homo sapiens
WAACCRCAR
YTGYGGTTW		 SELEX
Jolma et al.(2013)
RUNX2_3		 (Direct) (Direct)
RUNX2
M05733_2.00		 Homo sapiens
NHRACCRCADWAACCRCAVN
NBTGYGGTTWHTGYGGTYDN		 SELEX
Yin et al.(2017)
RUNX2_eDBD_HT-SELEX		 (Direct) (Direct)
RUNX2
M05734_2.00		 Homo sapiens
NWAACCACRAAAACCACRRN
NYYGTGGTTTTYGTGGTTWN		 SELEX
Yin et al.(2017)
RUNX2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
RUNX2
M09370_2.00		 Homo sapiens
MMHAACCACAVVMH
DKBBTGTGGTTDKK		 Misc
Kulakovskiy et al.(2013)
RUNX2_HUMAN.H11MO.0.A		 (Direct) (Direct)
RUNX2
M09630_2.00		 Homo sapiens
NHVACCACANNN
NNNTGTGGTBDN		 Misc
Heinz et al.(2010)
PCa-RUNX2_GSE33889		 (Direct) (Direct)
RUNX2
M11255_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML3_Q3		 (Direct) (Direct)
RUNX2
M11256_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML3_Q6		 (Direct) (Direct)
RUNX2
M11257_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$OSF2_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Runx2
M01307_2.00 		Mus musculus
NHDACCRCAN
NTGYGGTHDN		 PBM
Lambert et al.(2019)
pTH9764 		0.985 0.985
Runx2
M09373_2.00 		Mus musculus
VWRACCACARVV
BBYTGTGGTYWB		 Misc
Kulakovskiy et al.(2013)
RUNX2_MOUSE.H11MO.0.A 		1.000 1.000
RUNX3
M03464_2.00 		Homo sapiens
HRACCGCAAACCRCAN
NTGYGGTTTGCGGTYD		 SELEX
Jolma et al.(2013)
RUNX3_1 		0.946 0.946
RUNX3
M03465_2.00 		Homo sapiens
WAACCRCARN
NYTGYGGTTW		 SELEX
Jolma et al.(2013)
RUNX3_2 		0.946 0.946
RUNX3
M03466_2.00 		Homo sapiens
HDACCRCADWAACCRCRN
NYGYGGTTWHTGYGGTHD		 SELEX
Jolma et al.(2013)
RUNX3_3 		0.931 0.931
RUNX3
M03467_2.00 		Homo sapiens
HRACCRCAAH
DTTGYGGTYD		 SELEX
Jolma et al.(2013)
RUNX3_4 		0.931 0.931
RUNX3
M02751_2.00 		Homo sapiens
WACCRCAM
KTGYGGTW		 SELEX
Jolma et al.(2010)
RUNX3_monomer 		0.931 0.931
RUNX3
M05731_2.00 		Homo sapiens
YWAACCGCAAAAACCGCARV
BYTGCGGTTTTTGCGGTTWR		 SELEX
Yin et al.(2017)
RUNX3_FL_HT-SELEX 		0.931 0.931
RUNX3
M09369_2.00 		Homo sapiens
HAACCACARN
NYTGTGGTTD		 Misc
Kulakovskiy et al.(2013)
RUNX3_HUMAN.H11MO.0.A 		0.931 0.931
Runx3
M09374_2.00 		Mus musculus
NHRACCACARVN
NBYTGTGGTYDN		 Misc
Kulakovskiy et al.(2013)
RUNX3_MOUSE.H11MO.0.A 		0.931 0.931
RUNX3
M11252_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML2_Q3_01 		0.931 0.931
RUNX3
M11253_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML2_Q3 		0.946 0.946
RUNX3
M11254_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML2_Q4 		0.931 0.931
RUNX3
M05732_2.00 		Homo sapiens
HWAACCACRAAAACCACRARN
NYTYGTGGTTTTYGTGGTTWD		 SELEX
Yin et al.(2017)
RUNX3_FL_Methyl-HT-SELEX 		0.931 0.931
Runx1
M08163_2.00 		Mus musculus
HRRCCACARVN
NBYTGTGGYYD		 ChIP-seq
Mathelier et al.(2014)
MA0002.2 		0.908 0.908
RUNX1
M09371_2.00 		Homo sapiens
NWAACCACARV
BYTGTGGTTWN		 Misc
Kulakovskiy et al.(2013)
RUNX1_HUMAN.H11MO.0.A 		0.908 0.908
Runx1
M09372_2.00 		Mus musculus
VWRACCACARVV
BBYTGTGGTYWB		 Misc
Kulakovskiy et al.(2013)
RUNX1_MOUSE.H11MO.0.A 		0.908 0.908
RUNX1
M09632_2.00 		Homo sapiens
HAACCACADV
BHTGTGGTTD		 Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE29180 		0.908 0.908
RUNX1
M09631_2.00 		Homo sapiens
VCCACWTCCTBY
RVAGGAWGTGGB		 Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE17954 		0.923 0.923
Runx1
M09633_2.00 		Mus musculus
NWAACCACAR
YTGTGGTTWN		 Misc
Heinz et al.(2010)
HPC7-Runx1_GSE22178 		0.923 0.923
RUNX1
M11258_2.00 		Homo sapiens
ACCRCA
TGYGGT		 Transfac
Matys et al.(2006)
V$AML1_01 		0.908 0.908
RUNX1
M11259_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q4_01 		0.908 0.908
RUNX1
M11260_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q4_02 		0.908 0.908
RUNX1
M11261_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q4 		0.908 0.908
RUNX1
M11262_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q5 		0.908 0.908
RUNX1
M11263_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q6 		0.908 0.908
lz
M03964_2.00 		Drosophila melanogaster
HRACCGCAAHM
KDTTGCGGTYD		 SELEX
Nitta et al.(2015)
lz_1 		0.731 0.731
lz
M03965_2.00 		Drosophila melanogaster
HVACCRCARWAACCRCAV
BTGYGGTTWYTGYGGTBD		 SELEX
Nitta et al.(2015)
lz_2 		0.731 0.731
lz
M03966_2.00 		Drosophila melanogaster
WRACCRCAWTAACCRCAA
TTGYGGTTAWTGYGGTYW		 SELEX
Nitta et al.(2015)
lz_3 		0.731 0.731
lz
M03967_2.00 		Drosophila melanogaster
HRACCGCAAAACCRCAR
YTGYGGTTTTGCGGTYD		 SELEX
Nitta et al.(2015)
lz_4 		0.731 0.731
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000352514 Runt 88 217
ENSP00000360486 Runt 102 231
ENSP00000360491 Runt 102 231
ENSP00000360493 Runt 102 231
ENSP00000420707 Runt 102 231
ENSP00000458178 Runt 102 231
ENSP00000460188 Runt 88 217
ENSP00000485863 Runt 88 217

Links

Other Runt family TFs
Other Homo sapiens TFs

364 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AAEL006160 Aedes aegypti AAEL006160 I 0.762
AALB007752 Anopheles albimanus AALB007752 I 0.725
AALB009220 Anopheles albimanus AALB009220 I 0.731
AARA004356 Anopheles arabiensis AARA004356 I 0.723
AATE002063 Anopheles atroparvus AATE002063 I 0.762
ACEP16394 Atta cephalotes ACEP16394 I
ACEP16400 Atta cephalotes ACEP16400 I 0.762
ACEP16410 Atta cephalotes ACEP16410 I
ACYPI001442 Acyrthosiphon pisum ACYPI001442 I 0.738
ACYPI007541 Acyrthosiphon pisum ACYPI007541 I 0.738
ADAC004330 Anopheles darlingi ADAC004330 I
AEPI003479 Anopheles epiroticus AEPI003479 I 0.723
AFAF013225 Anopheles farauti AFAF013225 I 0.732
AGAP002506 Anopheles gambiae AGAP002506 I 0.723
AMAM011616 Anopheles maculatus AMAM011616 I 0.720
AMEM017856 Anopheles merus AMEM017856 I 0.723
ASTEI07771 Anopheles stephensi ASTEI07771 I 0.762
BGIBMGA008906 Bombyx mori BGIBMGA008906 I 0.700
CABZ01102124.1 Danio rerio ENSDARG00000103592 I 0.947
Cflo_03909--XP_394016.2_APIME Camponotus floridanus Cflo_03909--XP_394016.2_APIME I 0.785
Cflo_03910--XP_001121886.1_APIME Camponotus floridanus Cflo_03910--XP_001121886.1_APIME I
Cflo_03911--XP_394014.2_APIME Camponotus floridanus Cflo_03911--XP_394014.2_APIME I 0.754
Cflo_03913--XP_394013.3_APIME Camponotus floridanus Cflo_03913--XP_394013.3_APIME I 0.746
CLEC011124 Cimex lectularius CLEC011124 I 0.725
CPIJ006373 Culex quinquefasciatus CPIJ006373 I 0.725
CPIJ016825 Culex quinquefasciatus CPIJ016825 I 0.711
CpipJ_CPIJ006373 Culex pipiens CpipJ_CPIJ006373 I 0.725
CpipJ_CPIJ016825 Culex pipiens CpipJ_CPIJ016825 I 0.711
DAPPUDRAFT_290556 Daphnia pulex DAPPUDRAFT_290556 N
DAPPUDRAFT_290557 Daphnia pulex DAPPUDRAFT_290557 I 0.730
ENSAMXG00000000881 Astyanax mexicanus ENSAMXG00000000881 I 0.969
ENSAPLG00000007026 Anas platyrhynchos ENSAPLG00000007026 I 0.947
GA13742 Drosophila pseudoobscura FBgn0073778 I 0.708
GA22609 Drosophila pseudoobscura FBgn0244012 I 0.746
GB52719 Apis mellifera GB52719 I 0.708
GD16951 Drosophila simulans FBgn0188530 I 0.748
GD17495 Drosophila simulans FBgn0189047 I 0.708
GE17788 Drosophila yakuba FBgn0235232 I 0.731
GE17890 Drosophila yakuba FBgn0235328 I 0.708
GF15967 Drosophila ananassae FBgn0092990 I 0.708
GG18309 Drosophila erecta FBgn0110525 I 0.731
GG19691 Drosophila erecta FBgn0111893 I 0.708
GH17737 Drosophila grimshawi FBgn0125207 I 0.708
GJ19245 Drosophila virilis FBgn0206390 I 0.708
GK19810 Drosophila willistoni FBgn0221808 I 0.708
GK25373 Drosophila willistoni FBgn0227332 I 0.738
GL15800 Drosophila persimilis FBgn0153404 I 0.708
GL16499 Drosophila persimilis FBgn0154103 I 0.746
GM22478 Drosophila sechellia FBgn0177348 I 0.731
GM23044 Drosophila sechellia FBgn0177912 I 0.708
HMEL009842 Heliconius melpomene HMEL009842 I 0.769
Hsal_04635--XP_394013.3_APIME Harpegnathos saltator Hsal_04635--XP_394013.3_APIME I 0.746
Hsal_12319--XP_394016.2_APIME Harpegnathos saltator Hsal_12319--XP_394016.2_APIME I 0.785
KGM_21067 Danaus plexippus KGM_21067 I
LCUP002653 Lucilia cuprina LCUP002653 N
LCUP002656 Lucilia cuprina LCUP002656 I 0.738
LDEC020504 Leptinotarsa decemlineata LDEC020504 N
LLOJ002717 Lutzomyia longipalpis LLOJ002717 I 0.797
lz Drosophila melanogaster FBgn0002576 D 0.731
MCINX000297 Melitaea cinxia MCINX000297 N
MCINX000302 Melitaea cinxia MCINX000302 I 0.738
MDOA010744 Musca domestica MDOA010744 I 0.708
MDOA013149 Musca domestica MDOA013149 I 0.700
MESCA007078 Megaselia scalaris MESCA007078 I 0.730
NV10998 Nasonia vitripennis NV10998 I 0.746
NV11000 Nasonia vitripennis NV11000 I 0.769
PHUM333300 Pediculus humanus PHUM333300 I 0.762
PHUM333340 Pediculus humanus PHUM333340 I 0.738
PPAI006591 Phlebotomus papatasi PPAI006591 I 0.708
PPAI007797 Phlebotomus papatasi PPAI007797 I 0.725
RPRC005391 Rhodnius prolixus RPRC005391 I 0.785
runx2b Danio rerio ENSDARG00000059233 I 0.985
RunxB Drosophila melanogaster FBgn0259162 I 0.708
SINV13317 Solenopsis invicta SINV13317 I 0.785
TC005566 Tribolium castaneum TC005566 I 0.769
TC005796 Tribolium castaneum TC005796 I 0.769
TC006536 Tribolium castaneum TC006536 I 0.762
TC006542 Tribolium castaneum TC006542 I 0.723
tetur01g02340 Tetranychus urticae tetur01g02340 I 0.762
YQE_12218 Dendroctonus ponderosae YQE_12218 I 0.769