NKX2-2 (Homo sapiens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSG00000125820 T209829_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
NKX2-2
M10681_2.00		 Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01		 (Direct) (Direct)
NKX2-2
M10682_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01		 (Direct) (Direct)
NKX2-2
M10683_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.867 1.000
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.867 1.000
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.850 0.965
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.850 0.965
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.850 0.965
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.850 0.965
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.850 0.965
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.843 0.912
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.843 0.912
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.843 0.912
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.811 0.912
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.811 0.912
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.811 0.912
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.811 0.912
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.811 0.912
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.811 0.912
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.811 0.895
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.807 0.860
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.799 0.895
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.798 0.895
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.798 0.895
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.798 0.895
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.798 0.895
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.798 0.895
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.798 0.895
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.798 0.895
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.798 0.895
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.798 0.895
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.784 0.825
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.742 0.789
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.742 0.789
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.742 0.789
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.742 0.789
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.742 0.789
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.742 0.789
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.742 0.789
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.742 0.789
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.742 0.789
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.742 0.789
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.742 0.789
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.742 0.789
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.742 0.789
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.742 0.789
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.742 0.772
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.742 0.772
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.741 0.807
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.741 0.807
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.741 0.807
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.737 0.772
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.736 0.649
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.718 0.754
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.718 0.632
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.718 0.632
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.718 0.632
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.718 0.632
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.718 0.632
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.718 0.632
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.709 0.772
Q24782_9CNID
M02206_2.00 		Eleutheria dichotoma
TTAATTAA
TTAATTAA		 PBM
Weirauch et al.(2014)
pTH5486 		0.613 0.491
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000366347 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Homo sapiens TFs

821 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSAMEG00000011905 Ailuropoda melanoleuca ENSAMEG00000011905 I
ENSAMEG00000016060 Ailuropoda melanoleuca ENSAMEG00000016060 I
Alligator_sinensis_CCG021907.1 Alligator sinensis Alligator_sinensis_CCG021907.1 I
BHLHE41 Anolis carolinensis ENSACAG00000000432 I
BHLHE40 Anolis carolinensis ENSACAG00000012577 I
Afo_R006295 Aptenodytes forsteri Afo_R006295 I
ENSAMXG00000007020 Astyanax mexicanus ENSAMXG00000007020 I
ENSAMXG00000020366 Astyanax mexicanus ENSAMXG00000020366 I
ENSBTAP00000040772-D1 Bos grunniens ENSBTAP00000040772-D1 I
ENSP00000256495-D1 Bos grunniens ENSP00000256495-D1 I
BHLHE41 Bos taurus ENSBTAG00000030575 I
BHLHE40 Callithrix jacchus ENSCJAG00000015832 I
Aan_R007938 Calypte anna Aan_R007938 I
BHLHE40 Canis familiaris ENSCAFG00000005621 I
ENSCAFG00000031081 Canis familiaris ENSCAFG00000031081 I
ENSCPOG00000025122 Cavia porcellus ENSCPOG00000025122 I
Cmyd_10013122 Chelonia mydas Cmyd_10013122 I
Cmyd_10013769 Chelonia mydas Cmyd_10013769 I
ENSCSAG00000007728 Chlorocebus sabaeus ENSCSAG00000007728 I
ENSCSAG00000010905 Chlorocebus sabaeus ENSCSAG00000010905 I
bhlhe40 Danio rerio ENSDARG00000004060 I
bhlhe41 Danio rerio ENSDARG00000041691 I
BHLHE40 Dasypus novemcinctus ENSDNOG00000035717 I
ENSDORG00000006908 Dipodomys ordii ENSDORG00000006908 I
BHLHE41 Echinops telfairi ENSETEG00000017468 I
ENSECAG00000000494 Equus caballus ENSECAG00000000494 I
BHLHE40 Equus caballus ENSECAG00000015069 I
BHLHE40 Felis catus ENSFCAG00000002966 I
ENSFCAG00000022143 Felis catus ENSFCAG00000022143 I
ENSFALG00000003877 Ficedula albicollis ENSFALG00000003877 I
ENSFALG00000013572 Ficedula albicollis ENSFALG00000013572 I
ENSGMOG00000002353 Gadus morhua ENSGMOG00000002353 I
ENSGMOG00000003444 Gadus morhua ENSGMOG00000003444 I
ENSGMOG00000004494 Gadus morhua ENSGMOG00000004494 I
BHLHE40 Gallus gallus ENSGALG00000008308 I
BHLHE40 Gasterosteus aculeatus ENSGACG00000000659 I
bhlhe41 Gasterosteus aculeatus ENSGACG00000011684 I
bhlhe40 Gasterosteus aculeatus ENSGACG00000011940 I
Gfo_R015175 Geospiza fortis Gfo_R015175 I
BHLHE41 Gorilla gorilla ENSGGOG00000015498 I
BHLHE40 Gorilla gorilla ENSGGOG00000015864 I
BHLHE41 Homo sapiens ENSG00000123095 D
BHLHE40 Homo sapiens ENSG00000134107 D
ENSSTOG00000000793 Ictidomys tridecemlineatus ENSSTOG00000000793 I
ENSSTOG00000021007 Ictidomys tridecemlineatus ENSSTOG00000021007 I
ENSLACG00000013163 Latimeria chalumnae ENSLACG00000013163 I
ENSLOCG00000010962 Lepisosteus oculatus ENSLOCG00000010962 I
ENSLOCG00000015327 Lepisosteus oculatus ENSLOCG00000015327 I
BHLHE40 Loxodonta africana ENSLAFG00000004896 I
BHLHE41 Loxodonta africana ENSLAFG00000030711 I
ENSMMUP00000024507 Macaca fascicularis ENSMMUP00000024507 I
ENSP00000256495 Macaca fascicularis ENSP00000256495 I
ENSMMUG00000014588 Macaca mulatta ENSMMUG00000014588 I
ENSMMUG00000018629 Macaca mulatta ENSMMUG00000018629 I
ENSMEUG00000010801 Macropus eugenii ENSMEUG00000010801 I
ENSMEUG00000013058 Macropus eugenii ENSMEUG00000013058 I
BHLHE40 Monodelphis domestica ENSMODG00000004516 I
BHLHE41 Monodelphis domestica ENSMODG00000016551 I
ENSMPUG00000010346 Mustela putorius furo ENSMPUG00000010346 I
ENSMPUG00000017029 Mustela putorius furo ENSMPUG00000017029 I
Bhlhe40 Mus musculus ENSMUSG00000030103 D
Bhlhe41 Mus musculus ENSMUSG00000030256 D
Myotis_brandtii_BHLHE40_10019553 Myotis brandtii Myotis_brandtii_BHLHE40_10019553 I
Myotis_brandtii_BHLHE41_10027341 Myotis brandtii Myotis_brandtii_BHLHE41_10027341 I
BHLHE41 Myotis lucifugus ENSMLUG00000028371 I
ENSNLEG00000003704 Nomascus leucogenys ENSNLEG00000003704 I
ENSNLEG00000005307 Nomascus leucogenys ENSNLEG00000005307 I
ENSNLEG00000026535 Nomascus leucogenys ENSNLEG00000026535 I
ENSOPRG00000009637 Ochotona princeps ENSOPRG00000009637 I
ENSONIG00000014711 Oreochromis niloticus ENSONIG00000014711 I
ENSONIG00000019148 Oreochromis niloticus ENSONIG00000019148 I
ENSONIG00000020277 Oreochromis niloticus ENSONIG00000020277 I
BHLHE40 Ornithorhynchus anatinus ENSOANG00000003764 I
BHLHE40 Oryctolagus cuniculus ENSOCUG00000015177 I
bhlhe41 Oryzias latipes ENSORLG00000011401 I
dec1a Oryzias latipes ENSORLG00000012739 I
dec1b Oryzias latipes ENSORLG00000014397 I
BHLHE40 Otolemur garnettii ENSOGAG00000029762 I
ENSOGAG00000032001 Otolemur garnettii ENSOGAG00000032001 I
ENSOARG00000007840 Ovis aries ENSOARG00000007840 I
ENSOARG00000019968 Ovis aries ENSOARG00000019968 I
BHLHE41 Pan troglodytes ENSPTRG00000004779 I
BHLHE40 Pan troglodytes ENSPTRG00000014571 I
ENSPANG00000006688 Papio anubis ENSPANG00000006688 I
ENSPANG00000008563 Papio anubis ENSPANG00000008563 I
ENSPSIG00000016504 Pelodiscus sinensis ENSPSIG00000016504 I
ENSPSIG00000018157 Pelodiscus sinensis ENSPSIG00000018157 I
ENSPMAG00000003684 Petromyzon marinus ENSPMAG00000003684 I
ENSPFOG00000004275 Poecilia formosa ENSPFOG00000004275 I
ENSPFOG00000007800 Poecilia formosa ENSPFOG00000007800 I
ENSPFOG00000015542 Poecilia formosa ENSPFOG00000015542 I
Pvit_15832 Pogona vitticeps Pvit_15832 I
Pvit_19380 Pogona vitticeps Pvit_19380 I
ENSPPYG00000004372 Pongo abelii ENSPPYG00000004372 I
ENSPPYG00000013696 Pongo abelii ENSPPYG00000013696 I
BHLHE41 Pteropus vampyrus ENSPVAG00000004507 I
BHLHE40 Pteropus vampyrus ENSPVAG00000007723 I
Bhlhe40 Rattus norvegicus ENSRNOG00000007152 I
Bhlhe41 Rattus norvegicus ENSRNOG00000048961 I
ENSSSCG00000011534 Sus scrofa ENSSSCG00000011534 I
BHLHE41 Sus scrofa ENSSSCG00000028552 I
ENSTGUG00000012230 Taeniopygia guttata ENSTGUG00000012230 I
bhlhe41 Takifugu rubripes ENSTRUG00000005639 I
BHLHE40 Takifugu rubripes ENSTRUG00000011390 I
bhlhe40 Takifugu rubripes ENSTRUG00000014524 I
ENSTSYG00000002535 Tarsius syrichta ENSTSYG00000002535 I
bhlhe40 Tetraodon nigroviridis ENSTNIG00000007338 I
bhlhe41 Tetraodon nigroviridis ENSTNIG00000012152 I
BHLHE40 Tursiops truncatus ENSTTRG00000002786 I
BHLHE41 Tursiops truncatus ENSTTRG00000014501 I
bhlhe40.S Xenopus laevis XB-GENE-17337587 I
bhlhe40.L Xenopus laevis XB-GENE-865608 I
bhlhe40 Xenopus tropicalis XB-GENE-486416 I
bhlhe41 Xenopus tropicalis XB-GENE-994875 I
ENSXMAG00000001113 Xiphophorus maculatus ENSXMAG00000001113 I
ENSXMAG00000002248 Xiphophorus maculatus ENSXMAG00000002248 I
ENSXMAG00000008981 Xiphophorus maculatus ENSXMAG00000008981 I