HAND2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000164107 T034305_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HAND2
M04150_2.00		 Homo sapiens
MACACCTGBD
HVCAGGTGTK		 SELEX
Yin et al.(2017)
HAND2_eDBD_HT-SELEX		 (Direct) (Direct)
HAND2
M04151_2.00		 Homo sapiens
MACACCTGYD
HRCAGGTGTK		 SELEX
Yin et al.(2017)
HAND2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hand1
M08769_2.00 		Mus musculus
WGABRNWDNSCAGRNNH
DNNYCTGSNHWNYVTCW		 Misc
Kulakovskiy et al.(2013)
HAND1_MOUSE.H11MO.0.C 		0.393 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000352565 bHLH 100 152
ENSP00000427084 bHLH 2 27
ENSP00000477638 bHLH 69 121

Links

Other bHLH family TFs
Other Homo sapiens TFs

148 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSONIG00000016059 Oreochromis niloticus ENSONIG00000016059 I 0.914
HAND2 Otolemur garnettii ENSOGAG00000027928 I 0.914
ENSOCUG00000016256 Oryctolagus cuniculus ENSOCUG00000016256 I 0.914
HAND2 Ochotona princeps ENSOPRG00000010154 I 0.914
hand2 Oryzias latipes ENSORLG00000010967 I 0.914
HAND2 Pan troglodytes ENSPTRG00000016601 I 0.914
ENSPFOG00000009546 Poecilia formosa ENSPFOG00000009546 I 0.914
ENSPANG00000023378 Papio anubis ENSPANG00000023378 I 0.914
ENSOARG00000015352 Ovis aries ENSOARG00000015352 I 0.914
ENSNLEG00000006670 Nomascus leucogenys ENSNLEG00000006670 I 0.914
ENSMEUG00000010715 Macropus eugenii ENSMEUG00000010715 I 0.914
ENSLOCG00000013581 Lepisosteus oculatus ENSLOCG00000013581 I 0.914
HAND2 Loxodonta africana ENSLAFG00000029843 I 0.914
HAND2 Myotis lucifugus ENSMLUG00000002599 I 0.914
ENSMMUG00000018749 Macaca mulatta ENSMMUG00000018749 I 0.914
Hand2 Mus musculus ENSMUSG00000038193 I 0.914
ENSMPUG00000001909 Mustela putorius furo ENSMPUG00000001909 I 0.914
HAND2 Monodelphis domestica ENSMODG00000003548 I 0.914
ENSSHAG00000011188 Sarcophilus harrisii ENSSHAG00000011188 I 0.914
ENSSSCG00000009703 Sus scrofa ENSSSCG00000009703 I 0.914
Gfo_R010505 Geospiza fortis Gfo_R010505 I 0.914
ENSP00000352565-D1 Bos grunniens ENSP00000352565-D1 I 0.914
Cmyd_10016492 Chelonia mydas Cmyd_10016492 I 0.914
Ogr14661 Ophisaurus gracilis Ogr14661 I 0.914
e_gw.829.7.1 Branchiostoma floridae e_gw.829.7.1 I 0.914
hand2.S Xenopus laevis XB-GENE-6252408 I 0.914
hand2 Xenopus tropicalis XB-GENE-481426 I 0.914
estExt_fgenesh2_pm.C_20027 Branchiostoma floridae estExt_fgenesh2_pm.C_20027 I 0.914
Alligator_sinensis_CCG007905.1 Alligator sinensis Alligator_sinensis_CCG007905.1 I 0.914
Aan_R004859 Calypte anna Aan_R004859 I 0.914
HAND2 Taeniopygia guttata ENSTGUG00000006281 I 0.914
HAND2 Tupaia belangeri ENSTBEG00000007591 I 0.914
ENSSTOG00000023020 Ictidomys tridecemlineatus ENSSTOG00000023020 I 0.914
hand2 Tetraodon nigroviridis ENSTNIG00000005584 I 0.914
HAND2 Tursiops truncatus ENSTTRG00000001365 I 0.914
ENSXMAG00000015868 Xiphophorus maculatus ENSXMAG00000015868 I 0.914
HAND2 Vicugna pacos ENSVPAG00000006724 I 0.914
ENSLACG00000004329 Latimeria chalumnae ENSLACG00000004329 I 0.914
ENSPPYG00000015208 Pongo abelii ENSPPYG00000015208 I 0.914
HAND2 Dasypus novemcinctus ENSDNOG00000035702 I 0.914
hand2 Danio rerio ENSDARG00000008305 I 0.914
Hand2 Dipodomys ordii ENSDORG00000007304 I 0.914
HAND2 Equus caballus ENSECAG00000009657 I 0.914
ENSFALG00000011490 Ficedula albicollis ENSFALG00000011490 I 0.914
ENSCSAG00000003094 Chlorocebus sabaeus ENSCSAG00000003094 I 0.914
ENSCPOG00000001740 Cavia porcellus ENSCPOG00000001740 I 0.914
ENSAMEG00000014235 Ailuropoda melanoleuca ENSAMEG00000014235 I 0.914
ENSGMOG00000018978 Gadus morhua ENSGMOG00000018978 I 0.914
HAND2 Canis familiaris ENSCAFG00000007858 I 0.914
HAND2 Callithrix jacchus ENSCJAG00000005144 I 0.914
HAND2 Felis catus ENSFCAG00000031585 I 0.914
HAND2 Bos taurus ENSBTAG00000044123 I 0.914
HAND2 Gorilla gorilla ENSGGOG00000006147 I 0.914
hand2 Gasterosteus aculeatus ENSGACG00000016418 I 0.914
HAND2 Microcebus murinus ENSMICG00000009054 I 0.911
ISCW009436 Ixodes scapularis ISCW009436 I 0.894
L798_02599 Zootermopsis nevadensis L798_02599 I 0.894
PHUM088400 Pediculus humanus PHUM088400 I 0.894
ENSLOCG00000012444 Lepisosteus oculatus ENSLOCG00000012444 I 0.890
ENSAMXG00000025833 Astyanax mexicanus ENSAMXG00000025833 I 0.890
hand2.L Xenopus laevis XB-GENE-865126 I 0.890
Sakowv30003804m.g Saccoglossus kowalevskii Sakowv30003804m.g I 0.886
Hsal_12649--XP_001122645.1_APIME Harpegnathos saltator Hsal_12649--XP_001122645.1_APIME I 0.883
GB46056 Apis mellifera GB46056 I 0.883
Cflo_05798--XP_001122645.1_APIME Camponotus floridanus Cflo_05798--XP_001122645.1_APIME I 0.883
NV12516 Nasonia vitripennis NV12516 I 0.883
RPRC005573 Rhodnius prolixus RPRC005573 I 0.870
Ocbimv22024043m.g Octopus bimaculoides Ocbimv22024043m.g I 0.866
CGI_10023955 Crassostrea gigas CGI_10023955 I 0.866
HHAL010291-PA Halyomorpha halys HHAL010291-PA I 0.866
ACYPI009244 Acyrthosiphon pisum ACYPI009244 I 0.866
PPAI010228 Phlebotomus papatasi PPAI010228 I 0.862
SMAR011914 Strigamia maritima SMAR011914 I 0.862
tetur18g03540 Tetranychus urticae tetur18g03540 I 0.862
LLOJ007342 Lutzomyia longipalpis LLOJ007342 I 0.862
LotgiG104540 Lottia gigantea LotgiG104540 I 0.862
SMAR012521 Strigamia maritima SMAR012521 I 0.862
SINV12583 Solenopsis invicta SINV12583 I 0.855
ACEP24088 Atta cephalotes ACEP24088 I 0.855
CLEC007932 Cimex lectularius CLEC007932 I 0.852
AARA005336 Anopheles arabiensis AARA005336 I 0.839
AAEL002423 Aedes aegypti AAEL002423 I 0.839
AATE010223 Anopheles atroparvus AATE010223 I 0.839
CPIJ009732 Culex quinquefasciatus CPIJ009732 I 0.839
AGAP004386 Anopheles gambiae AGAP004386 I 0.839
AALB002515 Anopheles albimanus AALB002515 I 0.839
AMIN004773 Anopheles minimus AMIN004773 I 0.839
ACHR001840 Anopheles christyi ACHR001840 I 0.839
AMEC002742 Anopheles melas AMEC002742 I 0.839
ENSPSIG00000012804 Pelodiscus sinensis ENSPSIG00000012804 N 0.839
AQUA008454 Anopheles quadriannulatus AQUA008454 I 0.839
ASTEI10695 Anopheles stephensi ASTEI10695 I 0.839
ASIS021599 Anopheles sinensis ASIS021599 I 0.839
CpipJ_CPIJ009732 Culex pipiens CpipJ_CPIJ009732 I 0.839
AMAM001941 Anopheles maculatus AMAM001941 I 0.839
AMEM001490 Anopheles merus AMEM001490 I 0.839
ACUA000831 Anopheles culicifacies ACUA000831 I 0.839
AFUN005909 Anopheles funestus AFUN005909 I 0.839
AEPI007770 Anopheles epiroticus AEPI007770 I 0.839
ADIR005442 Anopheles dirus ADIR005442 I 0.839
AFAF019328 Anopheles farauti AFAF019328 I 0.839
ACOM029750 Anopheles coluzzii ACOM029750 I 0.839
Pvit_12366 Pogona vitticeps Pvit_12366 I 0.583
Ogr18916 Ophisaurus gracilis Ogr18916 N 0.530
ENSMICG00000003569 Microcebus murinus ENSMICG00000003569 I 0.530
Myotis_brandtii_HAND1_10034795 Myotis brandtii Myotis_brandtii_HAND1_10034795 I 0.393
HAND1 Felis catus ENSFCAG00000014986 I 0.393
ENSMPUG00000013570 Mustela putorius furo ENSMPUG00000013570 I 0.393
Hand1 Mus musculus ENSMUSG00000037335 D 0.393
Pvit_10616 Pogona vitticeps Pvit_10616 N 0.393
HAND2 Anolis carolinensis ENSACAG00000005500 N 0.393
ENSAMEG00000016692 Ailuropoda melanoleuca ENSAMEG00000016692 I 0.393
HAND1 Cavia porcellus ENSCPOG00000024064 I 0.393
HAND1 Gasterosteus aculeatus ENSGACG00000020816 I 0.393
Hand2 Rattus norvegicus ENSRNOG00000060448 N 0.393
ENSSSCG00000017070 Sus scrofa ENSSSCG00000017070 I 0.393
HAND1 Gorilla gorilla ENSGGOG00000004311 I 0.393
HAND1 Callithrix jacchus ENSCJAG00000009817 I 0.393
ENSSTOG00000025850 Ictidomys tridecemlineatus ENSSTOG00000025850 I 0.393
Hand1 Rattus norvegicus ENSRNOG00000002582 I 0.393
HAND1 Pteropus vampyrus ENSPVAG00000002261 I 0.393
HAND1 Dasypus novemcinctus ENSDNOG00000007934 I 0.393
ENSPANG00000013720 Papio anubis ENSPANG00000013720 I 0.393
Hand1 Dipodomys ordii ENSDORG00000015170 I 0.393
HAND1 Procavia capensis ENSPCAG00000006706 I 0.393
ENSPPYG00000015975 Pongo abelii ENSPPYG00000015975 I 0.393
HAND1 Pan troglodytes ENSPTRG00000017446 I 0.393
ENSCSAG00000010805 Chlorocebus sabaeus ENSCSAG00000010805 I 0.393
HAND1 Equus caballus ENSECAG00000005327 I 0.393
HAND1 Canis familiaris ENSCAFG00000017641 I 0.393
ENSNLEG00000016584 Nomascus leucogenys ENSNLEG00000016584 I 0.393
ENSOARG00000009843 Ovis aries ENSOARG00000009843 I 0.393
HAND1 Homo sapiens ENSG00000113196 I 0.393
HAND1 Ochotona princeps ENSOPRG00000014560 I 0.393
Alligator_sinensis_CCG014990.1 Alligator sinensis Alligator_sinensis_CCG014990.1 I 0.393
ENSLACG00000018666 Latimeria chalumnae ENSLACG00000018666 I 0.393
HAND1 Macaca mulatta ENSMMUG00000010621 I 0.393
HAND1 Echinops telfairi ENSETEG00000010988 I 0.393
HAND1 Oryctolagus cuniculus ENSOCUG00000011099 I 0.393
HAND1 Otolemur garnettii ENSOGAG00000024691 I 0.393
HAND1 Takifugu rubripes ENSTRUG00000003992 I 0.393
HAND1 Tetraodon nigroviridis ENSTNIG00000007631 I 0.393
HAND1 Tursiops truncatus ENSTTRG00000002725 I 0.393
HAND1 Loxodonta africana ENSLAFG00000017517 I 0.393
HAND1 Myotis lucifugus ENSMLUG00000008901 I 0.393
HAND1 Bos taurus ENSBTAG00000002335 I 0.393
ENSP00000231121 Macaca fascicularis ENSP00000231121 I 0.393