Mga (Mus musculus)
bHLH,T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH)
PF00907 (T-box) 		IPR001092
IPR001699 		ENSMUSG00000033943 T055467_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MGA
M02821_2.00 		Homo sapiens
RGGTGTGA
TCACACCY		 SELEX
Jolma et al.(2013)
MGA_1 		0.974 0.974
MGA
M02822_2.00 		Homo sapiens
AGGTGTKAHDTMACACCT
AGGTGTKAHDTMACACCT		 SELEX
Jolma et al.(2013)
MGA_2 		0.974 0.974
MGA
M02823_2.00 		Homo sapiens
VGTGTKAWWWTTCACRCB
VGYGTGAAWWWTMACACB		 SELEX
Jolma et al.(2013)
MGA_3 		0.974 0.974
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000043795 T-box 77 260
ENSMUSP00000043795 bHLH 2363 2414
ENSMUSP00000078853 T-box 77 260
ENSMUSP00000078853 bHLH 2193 2244
ENSMUSP00000106400 T-box 77 260
ENSMUSP00000106400 bHLH 2284 2335
ENSMUSP00000106401 T-box 77 260
ENSMUSP00000106401 bHLH 2402 2453
ENSMUSP00000119044 T-box 77 260
ENSMUSP00000119044 bHLH 2193 2244

Links

Other bHLH,T-box family TFs
Other Mus musculus TFs

47 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Mga Rattus norvegicus ENSRNOG00000006378 I 1.000
MGA Oryctolagus cuniculus ENSOCUG00000006505 I 0.987
ENSSTOG00000000653 Ictidomys tridecemlineatus ENSSTOG00000000653 I 0.987
MGA Myotis lucifugus ENSMLUG00000015227 I 0.979
ENSAMEG00000016587 Ailuropoda melanoleuca ENSAMEG00000016587 I 0.974
ENSP00000219905 Macaca fascicularis ENSP00000219905 I 0.974
ENSOARG00000020404 Ovis aries ENSOARG00000020404 I 0.974
MGA Tupaia belangeri ENSTBEG00000002010 I 0.974
MGA Microcebus murinus ENSMICG00000001788 I 0.974
ENSMPUG00000008968 Mustela putorius furo ENSMPUG00000008968 I 0.974
MGA Gorilla gorilla ENSGGOG00000001640 I 0.974
ENSNLEG00000003750 Nomascus leucogenys ENSNLEG00000003750 I 0.974
ENSTSYG00000014605 Tarsius syrichta ENSTSYG00000014605 I 0.974
ENSPPYG00000006380 Pongo abelii ENSPPYG00000006380 I 0.974
MGA Canis familiaris ENSCAFG00000009662 I 0.974
MGA Pan troglodytes ENSPTRG00000006953 I 0.974
MGA Pteropus vampyrus ENSPVAG00000013732 I 0.974
MGA Sorex araneus ENSSARG00000007043 I 0.974
ENSCSAG00000007832 Chlorocebus sabaeus ENSCSAG00000007832 I 0.974
MGA Felis catus ENSFCAG00000007347 I 0.974
MGA Tursiops truncatus ENSTTRG00000002514 I 0.974
MGA Otolemur garnettii ENSOGAG00000016028 I 0.974
MGA Equus caballus ENSECAG00000006544 I 0.974
MGA Homo sapiens ENSG00000174197 D 0.974
ENSP00000219905-D1 Bos grunniens ENSP00000219905-D1 I 0.970
MGA Vicugna pacos ENSVPAG00000006239 I 0.970
MGA Bos taurus ENSBTAG00000015138 I 0.970
MGA Choloepus hoffmanni ENSCHOG00000012044 I 0.970
MGA Callithrix jacchus ENSCJAG00000020688 I 0.970
MGA Erinaceus europaeus ENSEEUG00000004604 I 0.966
MGA Monodelphis domestica ENSMODG00000000052 I 0.919
MGA Procavia capensis ENSPCAG00000013131 I 0.919
Cmyd_10013542 Chelonia mydas Cmyd_10013542 I 0.915
MGA Meleagris gallopavo ENSMGAG00000011293 I 0.906
Afo_R002341 Aptenodytes forsteri Afo_R002341 I 0.902
Ogr06446 Ophisaurus gracilis Ogr06446 I 0.897
ENSGALG00000008653 Gallus gallus ENSGALG00000008653 I 0.897
Gfo_R014126 Geospiza fortis Gfo_R014126 I 0.897
MGA Ornithorhynchus anatinus ENSOANG00000004502 I 0.893
ENSFALG00000006030 Ficedula albicollis ENSFALG00000006030 I 0.893
ENSAPLG00000010304 Anas platyrhynchos ENSAPLG00000010304 I 0.885
Aan_R008874 Calypte anna Aan_R008874 I 0.876
Pvit_03503 Pogona vitticeps Pvit_03503 I 0.868
ENSLACG00000002619 Latimeria chalumnae ENSLACG00000002619 I 0.846
XP_002933783 Xenopus tropicalis XP_002933783 I 0.829
ENSLOCG00000011689 Lepisosteus oculatus ENSLOCG00000011689 I 0.761