skn-1 (Caenorhabditis elegans)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 WBGene00004804 T069402_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables Hsp70 protein binding activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; positive regulation of cellular response to manganese ion; and positive regulation of macromolecule metabolic process. Located in endoplasmic reticulum; mitochondrion; and nucleus. Is expressed in several structures, including AB; C; germ line; head; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to several human genes including NFE2L1 (NFE2 like bZIP transcription factor 1); NFE2L2 (NFE2 like bZIP transcription factor 2); and NFE2L3 (NFE2 like bZIP transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
skn-1
M00596_2.00		 Caenorhabditis elegans
NHRTCABBNH
DNVVTGAYDN		 PBM
Narasimhan et al.(2015)
pTH9913		 (Direct) (Direct)
skn-1
M08079_2.00		 Caenorhabditis elegans
RARATGATGAYAAWD
HWTTRTCATCATYTY		 ChIP-seq
Mathelier et al.(2014)
MA0547.1		 (Direct) (Direct)
skn-1
M10053_2.00		 Caenorhabditis elegans
DDVATGACAWDD
HHWTGTCATBHH		 Transfac
Matys et al.(2006)
N$SKN1_01		 (Direct) (Direct)
skn-1
M10054_2.00		 Caenorhabditis elegans
NWDWATCATBHN
NDVATGATWHWN		 Transfac
Matys et al.(2006)
N$SKN1_02		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.782 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00596_2.00 bZIP 51 83

DNA Binding Domains

Protein ID Domain From To Sequence
T19E7.2a bZIP 589 621
T19E7.2b bZIP 276 308
T19E7.2c.1 bZIP 499 531
T19E7.2c.2 bZIP 499 531
T19E7.2c.3 bZIP 499 531
T19E7.2c.4 bZIP 499 531
T19E7.2d bZIP 189 221

Links

Other bZIP family TFs
Other Caenorhabditis elegans TFs

4 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CRE13433 Caenorhabditis remanei CRE13433 I 0.811
CJA20487 Caenorhabditis japonica CJA20487 I 0.811
CBN29878 Caenorhabditis brenneri CBN29878 I 0.811