ZKSCAN3 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000189298 T095280_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of cellular senescence; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZKSCAN3
M02923_2.00		 Homo sapiens
TCGAGGYTAGMCCA
TGGKCTARCCTCGA		 SELEX
Jolma et al.(2013)
ZNF306_1		 (Direct) (Direct)
ZKSCAN3
M07696_2.00		 Homo sapiens
GGCTAGMCC
GGKCTAGCC		 ChIP-seq+ChIP-exo
Barazandeh et al.(2018)
ZKSCAN3.RCADE.OriginalMapping		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000252211 C2H2 ZF 314 336
ENSP00000252211 C2H2 ZF 342 364
ENSP00000252211 C2H2 ZF 370 392
ENSP00000252211 C2H2 ZF 398 420
ENSP00000252211 C2H2 ZF 426 448
ENSP00000252211 C2H2 ZF 480 502
ENSP00000252211 C2H2 ZF 508 530
ENSP00000341883 C2H2 ZF 166 188
ENSP00000341883 C2H2 ZF 194 216
ENSP00000341883 C2H2 ZF 222 244
ENSP00000341883 C2H2 ZF 250 272
ENSP00000341883 C2H2 ZF 278 300
ENSP00000341883 C2H2 ZF 332 354
ENSP00000341883 C2H2 ZF 360 382
ENSP00000366465 C2H2 ZF 314 336
ENSP00000366465 C2H2 ZF 342 364
ENSP00000366465 C2H2 ZF 370 392
ENSP00000366465 C2H2 ZF 398 420
ENSP00000366465 C2H2 ZF 426 448
ENSP00000366465 C2H2 ZF 480 502
ENSP00000366465 C2H2 ZF 508 530

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

15 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ZKSCAN3 Gorilla gorilla ENSGGOG00000000689 I 0.827
ENSPANG00000008440 Papio anubis ENSPANG00000008440 I 0.827
ENSPPYG00000016371 Pongo abelii ENSPPYG00000016371 I 0.827
ENSNLEG00000004558 Nomascus leucogenys ENSNLEG00000004558 I 0.827
ZKSCAN3 Pan troglodytes ENSPTRG00000017875 I 0.827
ENSP00000252211 Macaca fascicularis ENSP00000252211 I 0.819
ZKSCAN3 Macaca mulatta ENSMMUG00000018054 I 0.819
ENSCSAG00000008016 Chlorocebus sabaeus ENSCSAG00000008016 I 0.807
ZKSCAN3 Choloepus hoffmanni ENSCHOG00000012193 I 0.803
ZKSCAN3 Equus caballus ENSECAG00000013024 I 0.802
ENSTSYG00000004748 Tarsius syrichta ENSTSYG00000004748 I 0.801
ZKSCAN3 Dasypus novemcinctus ENSDNOG00000033262 I 0.800
ZKSCAN3 Otolemur garnettii ENSOGAG00000006596 I 0.788
ENSDORG00000014252 Dipodomys ordii ENSDORG00000014252 I 0.770