Mbd2 (Mus musculus)
MBD

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01429 (MBD) IPR001739 ENSMUSG00000024513 T260274_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables chromatin binding activity and nucleic acid binding activity. Acts upstream of or within several processes, including maternal behavior; negative regulation of transcription by RNA polymerase II; and positive regulation of Wnt signaling pathway. Located in cytoplasm; heterochromatin; and nucleus. Part of histone deacetylase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb ectoderm; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Mbd2
M09258_2.00		 Mus musculus
VSGKCCGGMKR
YMKCCGGMCSB		 Misc
Kulakovskiy et al.(2013)
MBD2_MOUSE.H11MO.0.B		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
MBD2
M09256_2.00 		Homo sapiens
VSGKCCGGMKR
YMKCCGGMCSB		 Misc
Kulakovskiy et al.(2013)
MBD2_HUMAN.H11MO.0.B 		0.982 0.982
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000073701 MBD 149 219
ENSMUSP00000073701 MBD 229 293
ENSMUSP00000110596 MBD 149 219

Links

Other MBD family TFs
Other Mus musculus TFs

63 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSMMUG00000003136 Macaca mulatta ENSMMUG00000003136 I 0.986
MBD2 Homo sapiens ENSG00000134046 D 0.986
MBD2 Loxodonta africana ENSLAFG00000014135 I 0.982
MBD2 Gorilla gorilla ENSGGOG00000013402 I 0.982
MBD2 Monodelphis domestica ENSMODG00000011041 I 0.982
ENSPANG00000021858 Papio anubis ENSPANG00000021858 I 0.982
ENSSTOG00000011253 Ictidomys tridecemlineatus ENSSTOG00000011253 I 0.982
MBD2 Sus scrofa ENSSSCG00000004528 I 0.982
Mbd2 Rattus norvegicus ENSRNOG00000011853 I 0.982
MBD2 Pan troglodytes ENSPTRG00000010033 I 0.982
MBD2 Dasypus novemcinctus ENSDNOG00000033421 I 0.982
MBD2 Oryctolagus cuniculus ENSOCUG00000021080 I 0.982
ENSAMEG00000017208 Ailuropoda melanoleuca ENSAMEG00000017208 I 0.982
ENSECAG00000022368 Equus caballus ENSECAG00000022368 I 0.973
MBD2 Cavia porcellus ENSCPOG00000006832 I 0.973
MBD2 Tursiops truncatus ENSTTRG00000009635 N 0.972
ENSOPRG00000007642 Ochotona princeps ENSOPRG00000007642 N 0.971
ENSCHOG00000012250 Choloepus hoffmanni ENSCHOG00000012250 N 0.971
MBD2 Callithrix jacchus ENSCJAG00000001862 I 0.964
MBD2 Otolemur garnettii ENSOGAG00000008028 I 0.964
MBD2 Tupaia belangeri ENSTBEG00000015292 I 0.964
ENSCSAG00000018106 Chlorocebus sabaeus ENSCSAG00000018106 I 0.937
Ogr03458 Ophisaurus gracilis Ogr03458 I 0.937
MBD2 Pteropus vampyrus ENSPVAG00000008555 N 0.930
ENSACAG00000008739 Anolis carolinensis ENSACAG00000008739 I 0.928
ENSLACG00000016038 Latimeria chalumnae ENSLACG00000016038 I 0.928
ENSP00000256429-D1 Bos grunniens ENSP00000256429-D1 I 0.874
ENSLOCG00000003370 Lepisosteus oculatus ENSLOCG00000003370 I 0.874
ENSXMAG00000003932 Xiphophorus maculatus ENSXMAG00000003932 I 0.856
ENSONIG00000012635 Oreochromis niloticus ENSONIG00000012635 I 0.847
mbd2.S Xenopus laevis XB-GENE-493780 I 0.842
ENSTNIG00000003709 Tetraodon nigroviridis ENSTNIG00000003709 I 0.838
MBD3 Gorilla gorilla ENSGGOG00000012396 N 0.833
MBD3 Oryzias latipes ENSORLG00000004850 N 0.833
ENSGACG00000018294 Gasterosteus aculeatus ENSGACG00000018294 I 0.829
ENSTRUG00000006522 Takifugu rubripes ENSTRUG00000006522 I 0.829
MBD3 Tetraodon nigroviridis ENSTNIG00000010627 N 0.820
ENSAMXG00000017952 Astyanax mexicanus ENSAMXG00000017952 I 0.806
ENSAMEG00000003491 Ailuropoda melanoleuca ENSAMEG00000003491 I 0.795
ENSPFOG00000003939 Poecilia formosa ENSPFOG00000003939 I 0.793
mbd3a Danio rerio ENSDARG00000061774 I 0.793
Ogr00377 Ophisaurus gracilis Ogr00377 N 0.792
mbd3.S Xenopus laevis XB-GENE-491557 I 0.784
ENSMEUG00000016480 Macropus eugenii ENSMEUG00000016480 I 0.772
mbd2 Danio rerio ENSDARG00000075952 I 0.766
ENSGMOG00000008953 Gadus morhua ENSGMOG00000008953 I 0.765
MBD2 Myotis lucifugus ENSMLUG00000009980 I 0.750
MBD3 Pteropus vampyrus ENSPVAG00000017085 I 0.748
estExt_fgenesh2_pg.C_2010088 Branchiostoma floridae estExt_fgenesh2_pg.C_2010088 N 0.739
Mbd3 Mus musculus ENSMUSG00000035478 N 0.739
ENSXMAG00000012716 Xiphophorus maculatus ENSXMAG00000012716 I 0.738
ENSPANG00000015324 Papio anubis ENSPANG00000015324 N 0.732
MBD3 Cavia porcellus ENSCPOG00000026210 N 0.732
ENSCSAG00000011976 Chlorocebus sabaeus ENSCSAG00000011976 N 0.732
MBD3 Homo sapiens ENSG00000071655 N 0.732
MBD3 Pan troglodytes ENSPTRG00000010209 N 0.732
MBD3 Macaca mulatta ENSMMUG00000009014 N 0.732
ENSNLEG00000001734 Nomascus leucogenys ENSNLEG00000001734 N 0.732
SMAR015035 Strigamia maritima SMAR015035 N 0.730
mbd3 Xenopus tropicalis XB-GENE-491553 I 0.725
MBD3 Otolemur garnettii ENSOGAG00000024563 N 0.718
ENSPPYG00000009325 Pongo abelii ENSPPYG00000009325 I 0.709
Mbd3 Dipodomys ordii ENSDORG00000004743 N 0.708