Thap1 (Mus musculus)
THAP finger

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF05485 (THAP) IPR006612 ENSMUSG00000037214 T348498_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including endothelial cell proliferation; negative regulation of transcription by RNA polymerase II; and transcription, DNA-templated. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Is expressed in forelimb bud and genitourinary system. Used to study torsion dystonia 6. Human ortholog(s) of this gene implicated in torsion dystonia 6. Orthologous to human THAP1 (THAP domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
THAP1
M08176_2.00 		Homo sapiens
DNHKGGMRR
YYKCCMDNH		 ChIP-seq
Mathelier et al.(2014)
MA0597.1 		0.947 0.947
THAP1
M08020_2.00 		Homo sapiens
SGCCATBTTKRNWVHGGGCRR
YYGCCCDBWNYMAAVATGGCS		 ChIP-seq
Gerstein et al.(2012)
K562_THAP1_HudsonAlpha 		0.947 0.947
THAP1
M09439_2.00 		Homo sapiens
GCCCDVVNBVRVSVKGGCBSCB
VGSVGCCMBSBYBVNBBHGGGC		 Misc
Kulakovskiy et al.(2013)
THAP1_HUMAN.H11MO.0.C 		0.974 0.974
THAP1
M11412_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_01 		0.974 0.974
THAP1
M11413_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_02 		0.947 0.947
THAP1
M11414_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$THAP1_04 		0.947 0.947
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000042464 THAP finger 4 83
ENSMUSP00000121153 THAP finger 1 60

Links

Other THAP finger family TFs
Other Mus musculus TFs

61 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSCPOG00000021608 Cavia porcellus ENSCPOG00000021608 I 0.987
Thap1 Rattus norvegicus ENSRNOG00000056956 I 0.987
ENSMMUG00000000162 Macaca mulatta ENSMMUG00000000162 I 0.974
THAP1 Loxodonta africana ENSLAFG00000003647 I 0.974
THAP1 Gorilla gorilla ENSGGOG00000022708 I 0.974
THAP1 Felis catus ENSFCAG00000027837 I 0.974
THAP1 Homo sapiens ENSG00000131931 D 0.974
THAP1 Oryctolagus cuniculus ENSOCUG00000001391 I 0.974
ENSP00000254250 Macaca fascicularis ENSP00000254250 I 0.974
THAP1 Vicugna pacos ENSVPAG00000001157 I 0.974
THAP1 Pan troglodytes ENSPTRG00000020211 I 0.974
ENSPANG00000007346 Papio anubis ENSPANG00000007346 I 0.974
THAP1 Echinops telfairi ENSETEG00000018764 I 0.974
ENSNLEG00000012946 Nomascus leucogenys ENSNLEG00000012946 I 0.974
THAP1 Callithrix jacchus ENSCJAG00000003466 I 0.974
ENSCSAG00000014961 Chlorocebus sabaeus ENSCSAG00000014961 I 0.974
ENSCHOG00000005563 Choloepus hoffmanni ENSCHOG00000005563 I 0.974
THAP1 Canis familiaris ENSCAFG00000005418 I 0.974
ENSAMEG00000004992 Ailuropoda melanoleuca ENSAMEG00000004992 I 0.974
THAP1 Dasypus novemcinctus ENSDNOG00000047233 I 0.974
ENSCHOG00000005457 Choloepus hoffmanni ENSCHOG00000005457 I 0.964
THAP1 Bos taurus ENSBTAG00000007629 I 0.961
THAP1 Erinaceus europaeus ENSEEUG00000003332 I 0.961
ENSSSCG00000027223 Sus scrofa ENSSSCG00000027223 I 0.961
ENSSTOG00000023122 Ictidomys tridecemlineatus ENSSTOG00000023122 I 0.961
ENSBTAP00000010035-D1 Bos grunniens ENSBTAP00000010035-D1 I 0.961
THAP1 Tursiops truncatus ENSTTRG00000008823 I 0.961
THAP1 Otolemur garnettii ENSOGAG00000002708 I 0.961
THAP1 Pteropus vampyrus ENSPVAG00000013496 I 0.961
Aan_R002310 Calypte anna Aan_R002310 I 0.947
THAP1 Gallus gallus ENSGALG00000015385 I 0.947
THAP1 Equus caballus ENSECAG00000000020 I 0.947
Afo_R005722 Aptenodytes forsteri Afo_R005722 I 0.947
ENSFALG00000005181 Ficedula albicollis ENSFALG00000005181 I 0.947
Tal_R008759 Tyto alba Tal_R008759 I 0.947
Gfo_R004116 Geospiza fortis Gfo_R004116 I 0.947
ENSPSIG00000017440 Pelodiscus sinensis ENSPSIG00000017440 I 0.947
ENSTSYG00000006585 Tarsius syrichta ENSTSYG00000006585 I 0.934
ENSOARG00000003516 Ovis aries ENSOARG00000003516 I 0.934
THAP1 Monodelphis domestica ENSMODG00000010093 I 0.934
Brh_R003908 Buceros rhinoceros Brh_R003908 I 0.930
ENSDORG00000014207 Dipodomys ordii ENSDORG00000014207 I 0.929
THAP1 Anolis carolinensis ENSACAG00000005705 I 0.912
THAP1 Myotis lucifugus ENSMLUG00000003837 I 0.912
THAP1 Ornithorhynchus anatinus ENSOANG00000000699 I 0.912
Pvit_16121 Pogona vitticeps Pvit_16121 I 0.912
Myotis_brandtii_thap1_10030544 Myotis brandtii Myotis_brandtii_thap1_10030544 I 0.912
thap1 Xenopus tropicalis XB-GENE-1008758 I 0.855
thap1.L Xenopus laevis XB-GENE-1008764 I 0.855
AAH77429 Xenopus laevis AAH77429 I 0.829
ENSLACG00000003453 Latimeria chalumnae ENSLACG00000003453 I 0.829
ENSLACG00000000288 Latimeria chalumnae ENSLACG00000000288 I 0.816
ENSAMXG00000007136 Astyanax mexicanus ENSAMXG00000007136 I 0.763
thap1 Oryzias latipes ENSORLG00000018779 I 0.750
ENSLOCG00000003237 Lepisosteus oculatus ENSLOCG00000003237 I 0.750
thap1 Gasterosteus aculeatus ENSGACG00000018371 I 0.737
ENSPFOG00000004261 Poecilia formosa ENSPFOG00000004261 I 0.737
ENSONIG00000012619 Oreochromis niloticus ENSONIG00000012619 I 0.724
ENSXMAG00000003907 Xiphophorus maculatus ENSXMAG00000003907 I 0.724
thap1 Danio rerio ENSDARG00000059020 N 0.711