UPC2 (Saccharomyces cerevisiae)
Zinc cluster

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00172 (Zn_clus) IPR001138 YDR213W T388340_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to hypoxia and positive regulation of transcription by RNA polymerase II. Located in membrane and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
UPC2
M00920_2.00		 Saccharomyces cerevisiae
NTCGTWYVN
NBRWACGAN		 PBM
Gordan et al.(2011)
Upc2		 (Direct) (Direct)
UPC2
M07508_2.00		 Saccharomyces cerevisiae
NRWACGA
TCGTWYN		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0411.1		 (Direct) (Direct)
UPC2
M08654_2.00		 Saccharomyces cerevisiae
NRWACGA
TCGTWYN		 Misc
DeBoer et al.(2011)
YDR213W_544		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ECM22
M00096_2.00 		Saccharomyces cerevisiae
NNCSGRDNHN
NDNHYCSGNN		 PBM
Badis et al.(2008)
ECM22_2066 		0.541 0.692
ECM22
M00924_2.00 		Saccharomyces cerevisiae
NNDWACGRN
NYCGTWHNN		 PBM
Gordan et al.(2011)
Ecm22 		0.541 0.692
ECM22
M01589_2.00 		Saccharomyces cerevisiae
NNNCGGVN
NBCCGNNN		 PBM
Zhu et al.(2009)
Ecm22 		0.541 0.692
ECM22
M07522_2.00 		Saccharomyces cerevisiae
TCCGGAD
HTCCGGA		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0292.1 		0.541 0.692
ECM22
M08679_2.00 		Saccharomyces cerevisiae
NNYCGGRNNDMCGGAVNH
DNBTCCGKHNNYCCGRNN		 Misc
DeBoer et al.(2011)
YLR228C_849 		0.541 0.692
For this family, TFs with SR scores > 0.537 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00920_2.00 Zinc cluster 49 88

DNA Binding Domains

Protein ID Domain From To Sequence
YDR213W Zinc cluster 49 88

Links

Other Zinc cluster family TFs
Other Saccharomyces cerevisiae TFs

22 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
4533_YDR213W Saccharomyces paradoxus 4533_YDR213W I 0.683
SU7_2615 Saccharomyces arboricola SU7_2615 I 0.667
4123_Multiple Saccharomyces mikatae 4123_Multiple I 0.667
4515_Multiple Saccharomyces bayanus 4515_Multiple I 0.667
KNAG_0A02550 Kazachstania naganishii KNAG_0A02550 I 0.596
SAKL0H13024g Lachancea kluyveri SAKL0H13024g I 0.596
Scas_Contig679.26 Saccharomyces castellii Scas_Contig679.26 I 0.594
NCAS_0C02730 Naumovozyma castellii NCAS_0C02730 I 0.594
17002_YLR228C Saccharomyces bayanus 17002_YLR228C I 0.571
NDAI_0E03460 Naumovozyma dairenensis NDAI_0E03460 I 0.564
EURHEDRAFT_400952 Aspergillus ruber EURHEDRAFT_400952 I 0.558
AACERI_AaceriAGL091W Saccharomycetaceae sp ashbya aceri AACERI_AaceriAGL091W I 0.549
AGOS_AGL091W Ashbya gossypii AGOS_AGL091W I 0.549
ZBAI_09613 Zygosaccharomyces bailii ZBAI_09613 I 0.549
Ecym_4144 Eremothecium cymbalariae Ecym_4144 I 0.547
Kwal_3122 Kluyveromyces waltii Kwal_3122 I 0.544
KLTH0F07854g Lachancea thermotolerans KLTH0F07854g I 0.544
KLTH0F07854g Kluyveromyces thermotolerans KLTH0F07854g I 0.544
ECM22 Saccharomyces cerevisiae YLR228C D 0.541
23482_Multiple Saccharomyces mikatae 23482_Multiple I 0.541
15982_YLR228C Saccharomyces paradoxus 15982_YLR228C I 0.541
NDAI_0C04840 Naumovozyma dairenensis NDAI_0C04840 I 0.539