MLX (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000108788 T034260_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
MLX
M02779_2.00
Homo sapiens
RTCACGTGAY

RTCACGTGAY
SELEX
Jolma et al.(2013)
MLX_1
(Direct) (Direct)
MLX
M04080_2.00
Homo sapiens
NCACGTGN

NCACGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_HT-SELEX
(Direct) (Direct)
MLX
M04081_2.00
Homo sapiens
NCACRTGV

BCAYGTGN
SELEX
Yin et al.(2017)
MLX_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
MLX
M04082_2.00
Homo sapiens
NVCACGTGVYN

NRBCACGTGBN
SELEX
Yin et al.(2017)
MLX_FL_HT-SELEX
(Direct) (Direct)
MLX
M04083_2.00
Homo sapiens
NDBCACRTGBV

BVCAYGTGVHN
SELEX
Yin et al.(2017)
MLX_FL_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Mlx
M00752_2.00
Mus musculus
CACGTGNNN

NNNCACGTG
PBM
Weirauch et al.(2013)
pTH2882
0.914 1.000
Mlx
M01721_2.00
Mus musculus
NCRCGTGNNN

NNNCACGYGN
PBM
Weirauch et al.(2014)
pTH5070
0.914 1.000
Mlx
M02815_2.00
Mus musculus
RTCACGTGAY

RTCACGTGAY
SELEX
Jolma et al.(2013)
Mlx_1
0.914 1.000
MLX
M01114_2.00
Monodelphis domestica
NNNCACGTGN

NCACGTGNNN
PBM
Lambert et al.(2019)
pTH11463
0.914 0.982
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000246912 bHLH 130 188
ENSP00000320913 bHLH 46 104
ENSP00000416627 bHLH 76 134
ENSP00000464697 bHLH 100 158

Links

Other bHLH family TFs
Other Homo sapiens TFs

52 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Aan_R006200 Calypte anna Aan_R006200 I 0.846
Alligator_sinensis_CCG005947.1 Alligator sinensis Alligator_sinensis_CCG005947.1 I 0.868
Cmyd_10007085 Chelonia mydas Cmyd_10007085 I 0.894
MLX Anolis carolinensis ENSACAG00000013679 I 0.868
ENSAMEG00000006549 Ailuropoda melanoleuca ENSAMEG00000006549 I 0.914
ENSAPLG00000003549 Anas platyrhynchos ENSAPLG00000003549 I 0.894
MLX Bos taurus ENSBTAG00000046670 I 0.889
MLX Canis familiaris ENSCAFG00000029102 I 0.914
ENSCHOG00000003363 Choloepus hoffmanni ENSCHOG00000003363 I 0.847
MLX Callithrix jacchus ENSCJAG00000005011 I 0.914
ENSCSAG00000003241 Chlorocebus sabaeus ENSCSAG00000003241 I 0.914
MLX Dasypus novemcinctus ENSDNOG00000045315 I 0.914
Mlx Dipodomys ordii ENSDORG00000006540 I 0.858
MLX Equus caballus ENSECAG00000023980 I 0.914
ENSEEUG00000003268 Erinaceus europaeus ENSEEUG00000003268 I 0.847
MLX Echinops telfairi ENSETEG00000017247 I 0.914
MLX Felis catus ENSFCAG00000011667 I 0.914
Mlx Gallus gallus ENSGALG00000003199 I 0.842
MLX Gorilla gorilla ENSGGOG00000010869 I 0.914
ENSLACG00000007918 Latimeria chalumnae ENSLACG00000007918 I 0.843
MLX Loxodonta africana ENSLAFG00000000328 I 0.914
ENSMEUG00000000185 Macropus eugenii ENSMEUG00000000185 I 0.858
MLX Microcebus murinus ENSMICG00000010258 I 0.914
MLX Myotis lucifugus ENSMLUG00000016670 I 0.914
MLX Macaca mulatta ENSMMUG00000009887 I 0.914
MLX Monodelphis domestica ENSMODG00000014918 D 0.914
ENSMPUG00000010285 Mustela putorius furo ENSMPUG00000010285 I 0.914
Mlx Mus musculus ENSMUSG00000017801 D 0.914
ENSOARG00000002343 Ovis aries ENSOARG00000002343 I 0.914
MLX Oryctolagus cuniculus ENSOCUG00000015210 I 0.914
MLX Otolemur garnettii ENSOGAG00000009867 I 0.914
MLX Ochotona princeps ENSOPRG00000012322 I 0.914
ENSP00000246912 Macaca fascicularis ENSP00000246912 I 0.914
ENSP00000246912-D1 Bos grunniens ENSP00000246912-D1 I 0.889
ENSPANG00000021416 Papio anubis ENSPANG00000021416 I 0.914
MLX Procavia capensis ENSPCAG00000014225 I 0.914
ENSPPYG00000008387 Pongo abelii ENSPPYG00000008387 I 0.914
ENSPSIG00000015412 Pelodiscus sinensis ENSPSIG00000015412 I 0.894
MLX Pan troglodytes ENSPTRG00000009208 I 0.914
MLX Pteropus vampyrus ENSPVAG00000016556 I 0.914
Mlx Rattus norvegicus ENSRNOG00000019983 I 0.914
MLX Sorex araneus ENSSARG00000014166 I 0.914
ENSSHAG00000014167 Sarcophilus harrisii ENSSHAG00000014167 I 0.914
MLX Sus scrofa ENSSSCG00000017397 I 0.914
ENSSTOG00000003660 Ictidomys tridecemlineatus ENSSTOG00000003660 I 0.914
MLX Tupaia belangeri ENSTBEG00000002111 I 0.914
ENSTSYG00000007534 Tarsius syrichta ENSTSYG00000007534 I 0.914
MLX Tursiops truncatus ENSTTRG00000016407 I 0.914
Myotis_brandtii_MLX_10015321 Myotis brandtii Myotis_brandtii_MLX_10015321 I 0.847
Ogr17012 Ophisaurus gracilis Ogr17012 I 0.894
Pvit_17633 Pogona vitticeps Pvit_17633 I 0.894