HAND2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000164107 T034305_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HAND2
M04150_2.00		 Homo sapiens
MACACCTGBD
HVCAGGTGTK		 SELEX
Yin et al.(2017)
HAND2_eDBD_HT-SELEX		 (Direct) (Direct)
HAND2
M04151_2.00		 Homo sapiens
MACACCTGYD
HRCAGGTGTK		 SELEX
Yin et al.(2017)
HAND2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hand1
M08769_2.00 		Mus musculus
WGABRNWDNSCAGRNNH
DNNYCTGSNHWNYVTCW		 Misc
Kulakovskiy et al.(2013)
HAND1_MOUSE.H11MO.0.C 		0.393 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000352565 bHLH 100 152
ENSP00000427084 bHLH 2 27
ENSP00000477638 bHLH 69 121

Links

Other bHLH family TFs
Other Homo sapiens TFs

148 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSONIG00000016059 Oreochromis niloticus ENSONIG00000016059 I 0.914
HAND2 Otolemur garnettii ENSOGAG00000027928 I 0.914
ENSOCUG00000016256 Oryctolagus cuniculus ENSOCUG00000016256 I 0.914
HAND2 Ochotona princeps ENSOPRG00000010154 I 0.914
hand2 Oryzias latipes ENSORLG00000010967 I 0.914
HAND2 Pan troglodytes ENSPTRG00000016601 I 0.914
ENSPFOG00000009546 Poecilia formosa ENSPFOG00000009546 I 0.914
ENSPANG00000023378 Papio anubis ENSPANG00000023378 I 0.914
ENSOARG00000015352 Ovis aries ENSOARG00000015352 I 0.914
ENSNLEG00000006670 Nomascus leucogenys ENSNLEG00000006670 I 0.914
ENSMEUG00000010715 Macropus eugenii ENSMEUG00000010715 I 0.914
ENSLOCG00000013581 Lepisosteus oculatus ENSLOCG00000013581 I 0.914
HAND2 Loxodonta africana ENSLAFG00000029843 I 0.914
HAND2 Myotis lucifugus ENSMLUG00000002599 I 0.914
ENSMMUG00000018749 Macaca mulatta ENSMMUG00000018749 I 0.914
Hand2 Mus musculus ENSMUSG00000038193 I 0.914
ENSMPUG00000001909 Mustela putorius furo ENSMPUG00000001909 I 0.914
HAND2 Monodelphis domestica ENSMODG00000003548 I 0.914
ENSSHAG00000011188 Sarcophilus harrisii ENSSHAG00000011188 I 0.914
ENSSSCG00000009703 Sus scrofa ENSSSCG00000009703 I 0.914
Gfo_R010505 Geospiza fortis Gfo_R010505 I 0.914
ENSP00000352565-D1 Bos grunniens ENSP00000352565-D1 I 0.914
Cmyd_10016492 Chelonia mydas Cmyd_10016492 I 0.914
Ogr14661 Ophisaurus gracilis Ogr14661 I 0.914
e_gw.829.7.1 Branchiostoma floridae e_gw.829.7.1 I 0.914
hand2.S Xenopus laevis XB-GENE-6252408 I 0.914
hand2 Xenopus tropicalis XB-GENE-481426 I 0.914
estExt_fgenesh2_pm.C_20027 Branchiostoma floridae estExt_fgenesh2_pm.C_20027 I 0.914
Alligator_sinensis_CCG007905.1 Alligator sinensis Alligator_sinensis_CCG007905.1 I 0.914
Aan_R004859 Calypte anna Aan_R004859 I 0.914
HAND2 Taeniopygia guttata ENSTGUG00000006281 I 0.914
HAND2 Tupaia belangeri ENSTBEG00000007591 I 0.914
ENSSTOG00000023020 Ictidomys tridecemlineatus ENSSTOG00000023020 I 0.914
hand2 Tetraodon nigroviridis ENSTNIG00000005584 I 0.914
HAND2 Tursiops truncatus ENSTTRG00000001365 I 0.914
ENSXMAG00000015868 Xiphophorus maculatus ENSXMAG00000015868 I 0.914
HAND2 Vicugna pacos ENSVPAG00000006724 I 0.914
ENSLACG00000004329 Latimeria chalumnae ENSLACG00000004329 I 0.914
ENSPPYG00000015208 Pongo abelii ENSPPYG00000015208 I 0.914
HAND2 Dasypus novemcinctus ENSDNOG00000035702 I 0.914
hand2 Danio rerio ENSDARG00000008305 I 0.914
Hand2 Dipodomys ordii ENSDORG00000007304 I 0.914
HAND2 Equus caballus ENSECAG00000009657 I 0.914
ENSFALG00000011490 Ficedula albicollis ENSFALG00000011490 I 0.914
ENSCSAG00000003094 Chlorocebus sabaeus ENSCSAG00000003094 I 0.914
ENSCPOG00000001740 Cavia porcellus ENSCPOG00000001740 I 0.914
ENSAMEG00000014235 Ailuropoda melanoleuca ENSAMEG00000014235 I 0.914
ENSGMOG00000018978 Gadus morhua ENSGMOG00000018978 I 0.914
HAND2 Canis familiaris ENSCAFG00000007858 I 0.914
HAND2 Callithrix jacchus ENSCJAG00000005144 I 0.914
HAND2 Felis catus ENSFCAG00000031585 I 0.914
HAND2 Bos taurus ENSBTAG00000044123 I 0.914
HAND2 Gorilla gorilla ENSGGOG00000006147 I 0.914
hand2 Gasterosteus aculeatus ENSGACG00000016418 I 0.914
HAND2 Microcebus murinus ENSMICG00000009054 I 0.911
ISCW009436 Ixodes scapularis ISCW009436 I 0.894
L798_02599 Zootermopsis nevadensis L798_02599 I 0.894
PHUM088400 Pediculus humanus PHUM088400 I 0.894
ENSLOCG00000012444 Lepisosteus oculatus ENSLOCG00000012444 I 0.890
ENSAMXG00000025833 Astyanax mexicanus ENSAMXG00000025833 I 0.890
hand2.L Xenopus laevis XB-GENE-865126 I 0.890
Sakowv30003804m.g Saccoglossus kowalevskii Sakowv30003804m.g I 0.886
Hsal_12649--XP_001122645.1_APIME Harpegnathos saltator Hsal_12649--XP_001122645.1_APIME I 0.883
GB46056 Apis mellifera GB46056 I 0.883
Cflo_05798--XP_001122645.1_APIME Camponotus floridanus Cflo_05798--XP_001122645.1_APIME I 0.883
NV12516 Nasonia vitripennis NV12516 I 0.883
RPRC005573 Rhodnius prolixus RPRC005573 I 0.870
Ocbimv22024043m.g Octopus bimaculoides Ocbimv22024043m.g I 0.866
CGI_10023955 Crassostrea gigas CGI_10023955 I 0.866
HHAL010291-PA Halyomorpha halys HHAL010291-PA I 0.866
ACYPI009244 Acyrthosiphon pisum ACYPI009244 I 0.866
PPAI010228 Phlebotomus papatasi PPAI010228 I 0.862
SMAR011914 Strigamia maritima SMAR011914 I 0.862
tetur18g03540 Tetranychus urticae tetur18g03540 I 0.862
LLOJ007342 Lutzomyia longipalpis LLOJ007342 I 0.862
LotgiG104540 Lottia gigantea LotgiG104540 I 0.862
SMAR012521 Strigamia maritima SMAR012521 I 0.862
SINV12583 Solenopsis invicta SINV12583 I 0.855
ACEP24088 Atta cephalotes ACEP24088 I 0.855
CLEC007932 Cimex lectularius CLEC007932 I 0.852
AARA005336 Anopheles arabiensis AARA005336 I 0.839
AAEL002423 Aedes aegypti AAEL002423 I 0.839
AATE010223 Anopheles atroparvus AATE010223 I 0.839
CPIJ009732 Culex quinquefasciatus CPIJ009732 I 0.839
AGAP004386 Anopheles gambiae AGAP004386 I 0.839
AALB002515 Anopheles albimanus AALB002515 I 0.839
AMIN004773 Anopheles minimus AMIN004773 I 0.839
ACHR001840 Anopheles christyi ACHR001840 I 0.839
AMEC002742 Anopheles melas AMEC002742 I 0.839
ENSPSIG00000012804 Pelodiscus sinensis ENSPSIG00000012804 N 0.839
AQUA008454 Anopheles quadriannulatus AQUA008454 I 0.839
ASTEI10695 Anopheles stephensi ASTEI10695 I 0.839
ASIS021599 Anopheles sinensis ASIS021599 I 0.839
CpipJ_CPIJ009732 Culex pipiens CpipJ_CPIJ009732 I 0.839
AMAM001941 Anopheles maculatus AMAM001941 I 0.839
AMEM001490 Anopheles merus AMEM001490 I 0.839
ACUA000831 Anopheles culicifacies ACUA000831 I 0.839
AFUN005909 Anopheles funestus AFUN005909 I 0.839
AEPI007770 Anopheles epiroticus AEPI007770 I 0.839
ADIR005442 Anopheles dirus ADIR005442 I 0.839
AFAF019328 Anopheles farauti AFAF019328 I 0.839
ACOM029750 Anopheles coluzzii ACOM029750 I 0.839
Pvit_12366 Pogona vitticeps Pvit_12366 I 0.583
Ogr18916 Ophisaurus gracilis Ogr18916 N 0.530
ENSMICG00000003569 Microcebus murinus ENSMICG00000003569 I 0.530
Myotis_brandtii_HAND1_10034795 Myotis brandtii Myotis_brandtii_HAND1_10034795 I 0.393
HAND1 Felis catus ENSFCAG00000014986 I 0.393
ENSMPUG00000013570 Mustela putorius furo ENSMPUG00000013570 I 0.393
Hand1 Mus musculus ENSMUSG00000037335 D 0.393
Pvit_10616 Pogona vitticeps Pvit_10616 N 0.393
HAND2 Anolis carolinensis ENSACAG00000005500 N 0.393
ENSAMEG00000016692 Ailuropoda melanoleuca ENSAMEG00000016692 I 0.393
HAND1 Cavia porcellus ENSCPOG00000024064 I 0.393
HAND1 Gasterosteus aculeatus ENSGACG00000020816 I 0.393
Hand2 Rattus norvegicus ENSRNOG00000060448 N 0.393
ENSSSCG00000017070 Sus scrofa ENSSSCG00000017070 I 0.393
HAND1 Gorilla gorilla ENSGGOG00000004311 I 0.393
HAND1 Callithrix jacchus ENSCJAG00000009817 I 0.393
ENSSTOG00000025850 Ictidomys tridecemlineatus ENSSTOG00000025850 I 0.393
Hand1 Rattus norvegicus ENSRNOG00000002582 I 0.393
HAND1 Pteropus vampyrus ENSPVAG00000002261 I 0.393
HAND1 Dasypus novemcinctus ENSDNOG00000007934 I 0.393
ENSPANG00000013720 Papio anubis ENSPANG00000013720 I 0.393
Hand1 Dipodomys ordii ENSDORG00000015170 I 0.393
HAND1 Procavia capensis ENSPCAG00000006706 I 0.393
ENSPPYG00000015975 Pongo abelii ENSPPYG00000015975 I 0.393
HAND1 Pan troglodytes ENSPTRG00000017446 I 0.393
ENSCSAG00000010805 Chlorocebus sabaeus ENSCSAG00000010805 I 0.393
HAND1 Equus caballus ENSECAG00000005327 I 0.393
HAND1 Canis familiaris ENSCAFG00000017641 I 0.393
ENSNLEG00000016584 Nomascus leucogenys ENSNLEG00000016584 I 0.393
ENSOARG00000009843 Ovis aries ENSOARG00000009843 I 0.393
HAND1 Homo sapiens ENSG00000113196 I 0.393
HAND1 Ochotona princeps ENSOPRG00000014560 I 0.393
Alligator_sinensis_CCG014990.1 Alligator sinensis Alligator_sinensis_CCG014990.1 I 0.393
ENSLACG00000018666 Latimeria chalumnae ENSLACG00000018666 I 0.393
HAND1 Macaca mulatta ENSMMUG00000010621 I 0.393
HAND1 Echinops telfairi ENSETEG00000010988 I 0.393
HAND1 Oryctolagus cuniculus ENSOCUG00000011099 I 0.393
HAND1 Otolemur garnettii ENSOGAG00000024691 I 0.393
HAND1 Takifugu rubripes ENSTRUG00000003992 I 0.393
HAND1 Tetraodon nigroviridis ENSTNIG00000007631 I 0.393
HAND1 Tursiops truncatus ENSTTRG00000002725 I 0.393
HAND1 Loxodonta africana ENSLAFG00000017517 I 0.393
HAND1 Myotis lucifugus ENSMLUG00000008901 I 0.393
HAND1 Bos taurus ENSBTAG00000002335 I 0.393
ENSP00000231121 Macaca fascicularis ENSP00000231121 I 0.393