CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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FIGLA
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000183733
T034331_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
FIGLA
M02805_2.00
Homo sapiens
HMCACCTGKN
NMCAGGTGKD
SELEX
Jolma et al.(2013)
FIGLA_1
(Direct)
(Direct)
FIGLA
M04205_2.00
Homo sapiens
HMCACCTGB
VCAGGTGKD
SELEX
Yin et al.(2017)
FIGLA_eDBD_HT-SELEX
(Direct)
(Direct)
FIGLA
M04206_2.00
Homo sapiens
HMCACCTGK
MCAGGTGKD
SELEX
Yin et al.(2017)
FIGLA_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Figla
M01737_2.00
Mus musculus
NNCASSTGN
NCASSTGNN
PBM
Weirauch et al.(2014)
pTH5105
0.890
0.923
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000333097
bHLH
66
118
RRRVANAKERERIKNLNRGFARLKALVPFLPQSRKPSKVDILKGATEYIQVLS
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
27 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy