TF Information

HES5 *(Homo sapiens)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSG00000197921	T034341_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
HES5 M02809_2.00	Homo sapiens	YGRCACGTGCCD	HGGCACGTGYCR	SELEX Jolma et al.(2013) HES5_1	(Direct)	(Direct)
HES5 M02810_2.00	Homo sapiens	YGGCACGTGCCR	YGGCACGTGCCR	SELEX Jolma et al.(2013) HES5_2	(Direct)	(Direct)
HES5 M04216_2.00	Homo sapiens	VRCACGTGCC	GGCACGTGYB	SELEX Yin et al.(2017) HES5_eDBD_HT-SELEX	(Direct)	(Direct)
HES5 M04217_2.00	Homo sapiens	VRCACGTGCC	GGCACGTGYB	SELEX Yin et al.(2017) HES5_eDBD_Methyl-HT-SELEX_1	(Direct)	(Direct)
HES5 M04218_2.00	Homo sapiens	VSACRCKY	RMGYGTSB	SELEX Yin et al.(2017) HES5_eDBD_Methyl-HT-SELEX_2	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hes5 M01747_2.00	Mus musculus	NVCRCGYGBN	NVCRCGYGBN	PBM Weirauch et al.(2014) pTH5450	0.914	1.000
For this family, TFs with SR scores > 0.838* will likely have a similar motif*