TF Information

Hif1a *(Mus musculus)* bHLH
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00010 (HLH)	IPR001092	ENSMUSG00000021109	T035677_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Hif1a M08750_2.00	Mus musculus	VDACGTGM	KCACGTHB	Misc Kulakovskiy et al.(2013) HIF1A_MOUSE.H11MO.0.C	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
HIF1A M08049_2.00	Homo sapiens	NBACGTGCNN	NNGCACGTVN	ChIP-seq Mathelier et al.(2014) MA1106.1	0.914	1.000
HIF1A M08713_2.00	Homo sapiens	VDACGTGM	KCACGTHB	Misc Kulakovskiy et al.(2013) HIF1A_HUMAN.H11MO.0.C	0.914	1.000
HIF1A M09454_2.00	Homo sapiens	KACGTGMN	NKCACGTM	Misc Heinz et al.(2010) MCF7-HIF1a_GSE28352	0.914	1.000
HIF1A M09807_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HIF1A_Q3	0.914	1.000
HIF1A M09808_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HIF1A_Q5	0.914	1.000
HIF1A M09809_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HIF1A_Q6	0.914	1.000
HIF1A M09810_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HIF1_Q3	0.914	1.000
HIF1A M09811_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$HIF1_Q5	0.914	1.000
For this family, TFs with SR scores > 0.838* will likely have a similar motif*