Clk (Drosophila melanogaster)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 FBgn0023076 T038425_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA binding activity; chromatin binding activity; and protein heterodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including circadian regulation of heart rate; locomotor rhythm; and regulation of gene expression. Part of CLOCK-BMAL transcription complex. Is expressed in several structures, including adult fat body; adult oenocyte; head; intrinsic neurons; and pacemaker neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to several human genes including CLOCK (clock circadian regulator) and NPAS2 (neuronal PAS domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Clk
M05972_2.00		 Drosophila melanogaster
MCACGTGV
BCACGTGK		 B1H
Zhu et al.(2011)
Clk_cyc_SANGER_5_FBgn0023076		 (Direct) (Direct)
Clk
M05973_2.00		 Drosophila melanogaster
CACGTGSY
RSCACGTG		 B1H
Zhu et al.(2011)
gce_Clk_SANGER_5_FBgn0023076		 (Direct) (Direct)
Clk
M05974_2.00		 Drosophila melanogaster
CACGTGKM
KACACGTG		 B1H
Zhu et al.(2011)
Met_Clk_SANGER_5_FBgn0023076		 (Direct) (Direct)
Clk
M05975_2.00		 Drosophila melanogaster
SACACGTGY
RCACGTGTS		 B1H
Zhu et al.(2011)
tai_Clk_SANGER_5_FBgn0023076		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0076500 bHLH 12 61
FBpp0099478 bHLH 16 65

Links

Other bHLH family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

31 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action