hlh-30 (Caenorhabditis elegans)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 WBGene00020930 T046306_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to bacterium; determination of adult lifespan; and positive regulation of macromolecule metabolic process. Acts upstream of or within positive regulation of plasma membrane repair and positive regulation of xenophagy. Located in cytoplasm and nucleus. Is expressed in several structures, including anal depressor muscle; nervous system; rectal valve cell; reproductive system; and somatic cell. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg's syndrome (multiple); familial melanoma; and renal cell carcinoma. Orthologous to several human genes including MITF (melanocyte inducing transcription factor) and TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
hlh-30
M00937_2.00		 Caenorhabditis elegans
WCACGTGA
TCACGTGW		 PBM
Grove et al.(2009)
HLH30		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00937_2.00 bHLH 264 317

DNA Binding Domains

Protein ID Domain From To Sequence
W02C12.3a.1 bHLH 238 291
W02C12.3a.2 bHLH 238 291
W02C12.3b bHLH 239 292
W02C12.3c bHLH 264 317
W02C12.3d bHLH 204 257
W02C12.3e bHLH 179 232
W02C12.3f bHLH 213 266
W02C12.3g.1 bHLH 238 291
W02C12.3g.2 bHLH 238 291
W02C12.3h.1 bHLH 101 154
W02C12.3h.2 bHLH 101 154
W02C12.3h.3 bHLH 101 154

Links

Other bHLH family TFs
Other Caenorhabditis elegans TFs

Invalid Input OrderBy

38 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action