CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ENSP00000357348
(
Macaca fascicularis
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
PF00010 (HLH)
IPR001092
ENSP00000357348
T047265_2.00
GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Hey2
M01722_2.00
Mus musculus
RCACGTGNN
NNCACGTGY
PBM
Weirauch et al.(2014)
pTH5102
0.914
1.000
HEY2
M02790_2.00
Homo sapiens
GRCACGTGNV
BNCACGTGYC
SELEX
Jolma et al.(2013)
HEY2_1
0.914
1.000
HEY2
M02791_2.00
Homo sapiens
GVCACGTGYN
NRCACGTGBC
SELEX
Jolma et al.(2013)
HEY2_2
0.914
1.000
HEY2
M04131_2.00
Homo sapiens
NVCRCGYGVN
NBCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_HT-SELEX
0.914
1.000
HEY2
M04133_2.00
Homo sapiens
NVCACGTGVN
NBCACGTGBN
SELEX
Yin et al.(2017)
HEY2_FL_HT-SELEX
0.914
1.000
HEY2
M04132_2.00
Homo sapiens
NVCRCGYRVN
NBYRCGYGBN
SELEX
Yin et al.(2017)
HEY2_eDBD_Methyl-HT-SELEX
0.914
1.000
HEY2
M04134_2.00
Homo sapiens
NVCRCGYGSN
NSCRCGYGBN
SELEX
Yin et al.(2017)
HEY2_FL_Methyl-HT-SELEX
0.914
1.000
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000357348
bHLH
49
104
RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQ
Links
Other
bHLH
family TFs
Other
Macaca fascicularis
TFs
163 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy