GLIS3 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000107249 T094847_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GLIS3
M02880_2.00
Homo sapiens
CTTYGTGGGGGGTM

KACCCCCCACRAAG
SELEX
Jolma et al.(2013)
GLIS3_1
(Direct) (Direct)
GLIS3
M10169_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_01
(Direct) (Direct)
GLIS3
M10170_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_Q6_01
(Direct) (Direct)
GLIS3
M10171_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$ZNF515_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000325494 C2H2 ZF 345 370
ENSP00000325494 C2H2 ZF 379 406
ENSP00000325494 C2H2 ZF 413 436
ENSP00000325494 C2H2 ZF 442 466
ENSP00000325494 C2H2 ZF 472 496
ENSP00000371398 C2H2 ZF 500 525
ENSP00000371398 C2H2 ZF 534 561
ENSP00000371398 C2H2 ZF 568 591
ENSP00000371398 C2H2 ZF 597 621
ENSP00000371398 C2H2 ZF 627 651

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

81 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAPLG00000013972 Anas platyrhynchos ENSAPLG00000013972 I 0.769
ENSAPLG00000014844 Anas platyrhynchos ENSAPLG00000014844 I 0.818
GLIS3 Anolis carolinensis ENSACAG00000003374 I 0.826
Afo_R001041 Aptenodytes forsteri Afo_R001041 I 0.769
Afo_R016063 Aptenodytes forsteri Afo_R016063 I 0.818
ENSAMXG00000005278 Astyanax mexicanus ENSAMXG00000005278 I 0.812
ENSAMXG00000019181 Astyanax mexicanus ENSAMXG00000019181 I 0.771
ENSP00000384734-D2 Bos grunniens ENSP00000384734-D2 I 0.825
gw.28.157.1 Branchiostoma floridae gw.28.157.1 I 0.807
e_gw.471.22.1 Branchiostoma floridae e_gw.471.22.1 I 0.807
Brh_R013214 Buceros rhinoceros Brh_R013214 I 0.767
GLIS3 Callithrix jacchus ENSCJAG00000011083 I 0.827
Aan_R004053 Calypte anna Aan_R004053 I 0.769
Aan_R004381 Calypte anna Aan_R004381 I 0.816
GLIS3 Canis familiaris ENSCAFG00000031499 I 0.818
GLIS1 Cavia porcellus ENSCPOG00000009497 I 0.816
GLIS3 Cavia porcellus ENSCPOG00000005523 I 0.827
glis1b Danio rerio ENSDARG00000027933 I 0.812
glis1a Danio rerio ENSDARG00000068580 I 0.788
DAPPUDRAFT_347217 Daphnia pulex DAPPUDRAFT_347217 I 0.769
GLIS3 Echinops telfairi ENSETEG00000015977 I 0.825
GLIS3 Equus caballus ENSECAG00000020544 I 0.827
GLIS3 Erinaceus europaeus ENSEEUG00000004107 I 0.770
ENSFALG00000011974 Ficedula albicollis ENSFALG00000011974 I 0.767
ENSFALG00000010519 Ficedula albicollis ENSFALG00000010519 I 0.810
ENSGMOG00000018511 Gadus morhua ENSGMOG00000018511 I 0.812
ENSGALG00000010721 Gallus gallus ENSGALG00000010721 I 0.769
GLIS3 Gallus gallus ENSGALG00000010180 I 0.817
GLIS1 Gasterosteus aculeatus ENSGACG00000012109 I 0.812
Gfo_R010168 Geospiza fortis Gfo_R010168 I 0.767
Gfo_R012286 Geospiza fortis Gfo_R012286 I 0.809
ENSSTOG00000000302 Ictidomys tridecemlineatus ENSSTOG00000000302 I 0.827
ENSLACG00000012147 Latimeria chalumnae ENSLACG00000012147 I 0.769
ENSLOCG00000012972 Lepisosteus oculatus ENSLOCG00000012972 I 0.824
ENSLOCG00000003071 Lepisosteus oculatus ENSLOCG00000003071 I 0.816
ENSP00000371398 Macaca fascicularis ENSP00000371398 I 0.827
ENSMEUG00000009882 Macropus eugenii ENSMEUG00000009882 I 0.816
ENSMEUG00000005102 Macropus eugenii ENSMEUG00000005102 I 0.827
GLIS1 Meleagris gallopavo ENSMGAG00000011303 I 0.769
ML145833a Mnemiopsis leidyi ML145833a I 0.758
GLIS3 Monodelphis domestica ENSMODG00000015403 I 0.827
ENSMPUG00000005095 Mustela putorius furo ENSMPUG00000005095 I 0.827
Glis3 Mus musculus ENSMUSG00000052942 I 0.827
Myotis_brandtii_GLIS3_10023567 Myotis brandtii Myotis_brandtii_GLIS3_10023567 I 0.827
ENSNLEG00000008824 Nomascus leucogenys ENSNLEG00000008824 I 0.827
Ocbimv22014778m.g Octopus bimaculoides Ocbimv22014778m.g I 0.757
Ogr17806 Ophisaurus gracilis Ogr17806 I 0.818
ENSONIG00000014033 Oreochromis niloticus ENSONIG00000014033 I 0.805
ENSOANG00000014997 Ornithorhynchus anatinus ENSOANG00000014997 I 0.827
ENSORLG00000007755 Oryzias latipes ENSORLG00000007755 I 0.807
ENSORLG00000003872 Oryzias latipes ENSORLG00000003872 I 0.812
GLIS3 Otolemur garnettii ENSOGAG00000007376 I 0.827
ENSOARG00000013378 Ovis aries ENSOARG00000013378 I 0.825
GLIS1 Pan troglodytes ENSPTRG00000000756 I 0.772
ENSPANG00000025157 Papio anubis ENSPANG00000025157 I 0.827
ENSPSIG00000002846 Pelodiscus sinensis ENSPSIG00000002846 I 0.769
ENSPSIG00000005966 Pelodiscus sinensis ENSPSIG00000005966 I 0.827
ENSPFOG00000017914 Poecilia formosa ENSPFOG00000017914 I 0.812
ENSPFOG00000019805 Poecilia formosa ENSPFOG00000019805 I 0.807
ENSPFOG00000002618 Poecilia formosa ENSPFOG00000002618 I 0.794
Pvit_11533 Pogona vitticeps Pvit_11533 I 0.769
Pvit_10484 Pogona vitticeps Pvit_10484 I 0.816
ENSPPYG00000019250 Pongo abelii ENSPPYG00000019250 I 0.818
GLIS3 Procavia capensis ENSPCAG00000004139 I 0.818
GLIS3 Pteropus vampyrus ENSPVAG00000001839 I 0.827
Glis3 Rattus norvegicus ENSRNOG00000014768 I 0.827
Sakowv30037345m.g Saccoglossus kowalevskii Sakowv30037345m.g I 0.810
SMAR005079 Strigamia maritima SMAR005079 I 0.773
SPU_018744 Strongylocentrotus purpuratus SPU_018744 I 0.812
GLIS1 Taeniopygia guttata ENSTGUG00000009294 I 0.767
GLIS3 Taeniopygia guttata ENSTGUG00000005266 I 0.812
ENSTRUG00000001198 Takifugu rubripes ENSTRUG00000001198 I 0.812
ENSTSYG00000000686 Tarsius syrichta ENSTSYG00000000686 I 0.827
GLIS1 Tetraodon nigroviridis ENSTNIG00000010694 I 0.812
Tal_R012308 Tyto alba Tal_R012308 I 0.767
GLIS3 Vicugna pacos ENSVPAG00000005473 I 0.825
glis3 Xenopus tropicalis XB-GENE-984727 I 0.817
ENSXMAG00000005013 Xiphophorus maculatus ENSXMAG00000005013 I 0.798
ENSXMAG00000005337 Xiphophorus maculatus ENSXMAG00000005337 I 0.794
ENSXMAG00000013077 Xiphophorus maculatus ENSXMAG00000013077 I 0.812