SP2 (Homo sapiens)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSG00000167182 T095047_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
SP2
M04525_2.00
Homo sapiens
NYWAGYCCCGCCCMCYH

DRGKGGGCGGGRCTWRN
SELEX
Yin et al.(2017)
SP2_eDBD_HT-SELEX
(Direct) (Direct)
SP2
M04526_2.00
Homo sapiens
NTWAGYCCCGCCCMCTT

AAGKGGGCGGGRCTWAN
SELEX
Yin et al.(2017)
SP2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)
SP2
M07932_2.00
Homo sapiens
KSCTAGAGMGGCBVB

VBVGCCKCTCTAGSM
ChIP-seq
Gerstein et al.(2012)
K562_SP2_HudsonAlpha
(Direct) (Direct)
SP2
M08092_2.00
Homo sapiens
BYCCCGCCYCYBNNB

VNNVRGRGGCGGGRV
ChIP-seq
Mathelier et al.(2014)
MA0516.1
(Direct) (Direct)
SP2
M08326_2.00
Homo sapiens
YCCCGCCCM

KGGGCGGGR
ChIP-seq
Schmitges et al.(2016)
Q02086_1-3.RCADE
(Direct) (Direct)
SP2
M08911_2.00
Homo sapiens
SBBSNVSBCCCGCCYCYBBBBS

SVVVVRGRGGCGGGVSBNSVVS
Misc
Kulakovskiy et al.(2013)
SP2_HUMAN.H11MO.0.A
(Direct) (Direct)
SP2
M10250_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_01
(Direct) (Direct)
SP2
M10251_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_04
(Direct) (Direct)
SP2
M10252_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_06
(Direct) (Direct)
SP2
M10253_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_Q3_01
(Direct) (Direct)
SP2
M10254_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Sp2
M08970_2.00
Mus musculus
SBBSNVSBCCCGCCYCYBBBBS

SVVVVRGRGGCGGGVSBNSVVS
Misc
Kulakovskiy et al.(2013)
SP2_MOUSE.H11MO.0.B
0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000365931 C2H2 ZF 525 549
ENSP00000365931 C2H2 ZF 555 579
ENSP00000365931 C2H2 ZF 585 607

Links

Other C2H2 ZF family TFs
Other Homo sapiens TFs

55 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Aan_R002402 Calypte anna Aan_R002402 I 0.807
Alligator_sinensis_CCG014457.1 Alligator sinensis Alligator_sinensis_CCG014457.1 I 0.807
ENSAMEG00000004772 Ailuropoda melanoleuca ENSAMEG00000004772 I 0.827
ENSAMXG00000018374 Astyanax mexicanus ENSAMXG00000018374 I 0.796
ENSCHOG00000008313 Choloepus hoffmanni ENSCHOG00000008313 I 0.827
ENSCSAG00000002567 Chlorocebus sabaeus ENSCSAG00000002567 I 0.827
ENSGMOG00000007030 Gadus morhua ENSGMOG00000007030 I 0.804
ENSLACG00000006434 Latimeria chalumnae ENSLACG00000006434 I 0.807
ENSLOCG00000013729 Lepisosteus oculatus ENSLOCG00000013729 I 0.807
ENSMICG00000014053 Microcebus murinus ENSMICG00000014053 I 0.827
ENSMPUG00000015289 Mustela putorius furo ENSMPUG00000015289 I 0.827
ENSNLEG00000002058 Nomascus leucogenys ENSNLEG00000002058 I 0.827
ENSOARG00000007752 Ovis aries ENSOARG00000007752 I 0.827
ENSONIG00000000117 Oreochromis niloticus ENSONIG00000000117 I 0.804
ENSP00000365931 Macaca fascicularis ENSP00000365931 I 0.827
ENSPANG00000022922 Papio anubis ENSPANG00000022922 I 0.827
ENSPFOG00000013068 Poecilia formosa ENSPFOG00000013068 I 0.804
ENSPPYG00000008885 Pongo abelii ENSPPYG00000008885 I 0.827
ENSSHAG00000005633 Sarcophilus harrisii ENSSHAG00000005633 I 0.823
ENSSTOG00000015926 Ictidomys tridecemlineatus ENSSTOG00000015926 I 0.827
ENSXMAG00000014321 Xiphophorus maculatus ENSXMAG00000014321 I 0.804
Myotis_brandtii_SP2_10030436 Myotis brandtii Myotis_brandtii_SP2_10030436 I 0.827
Ogr12593 Ophisaurus gracilis Ogr12593 I 0.807
Pvit_13958 Pogona vitticeps Pvit_13958 I 0.807
sp2 Tetraodon nigroviridis ENSTNIG00000006290 I 0.800
SP2 Canis familiaris ENSCAFG00000016812 I 0.827
SP2 Cavia porcellus ENSCPOG00000014943 I 0.827
SP2 Sorex araneus ENSSARG00000003559 I 0.827
Sp2 Rattus norvegicus ENSRNOG00000010492 I 0.827
sp2 Takifugu rubripes ENSTRUG00000007642 I 0.800
SP2 Tursiops truncatus ENSTTRG00000012483 I 0.814
SP2 Loxodonta africana ENSLAFG00000021817 I 0.827
SP2 Bos taurus ENSBTAG00000013740 I 0.827
SP2 Callithrix jacchus ENSCJAG00000007713 I 0.827
SP2 Anolis carolinensis ENSACAG00000006793 I 0.803
sp2 Xenopus tropicalis XB-GENE-968274 I 0.806
SP2 Pteropus vampyrus ENSPVAG00000004255 I 0.827
SP2 Pan troglodytes ENSPTRG00000009342 I 0.827
sp2 Danio rerio ENSDARG00000076763 I 0.800
SP2 Gorilla gorilla ENSGGOG00000005330 I 0.827
SP2 Myotis lucifugus ENSMLUG00000005000 I 0.827
SP2 Macaca mulatta ENSMMUG00000004765 I 0.827
SP2 Monodelphis domestica ENSMODG00000012452 I 0.797
SP2 Gallus gallus ENSGALG00000000233 I 0.807
Sp2 Mus musculus ENSMUSG00000018678 D 0.827
sp2 Gasterosteus aculeatus ENSGACG00000019811 I 0.804
SP2 Felis catus ENSFCAG00000009365 I 0.827
SP2 Oryctolagus cuniculus ENSOCUG00000027415 I 0.827
SP2 Otolemur garnettii ENSOGAG00000030380 I 0.827
SP2 Echinops telfairi ENSETEG00000009168 I 0.827
sp2 Oryzias latipes ENSORLG00000000102 I 0.800
SP2 Erinaceus europaeus ENSEEUG00000014248 I 0.827
SP2 Procavia capensis ENSPCAG00000002140 I 0.827
SP2 Equus caballus ENSECAG00000012859 I 0.827
sp2.S Xenopus laevis XB-GENE-968279 I 0.806