CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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SP2
(
Homo sapiens
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
ENSG00000167182
T095047_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
SP2
M04525_2.00
Homo sapiens
NYWAGYCCCGCCCMCYH
DRGKGGGCGGGRCTWRN
SELEX
Yin et al.(2017)
SP2_eDBD_HT-SELEX
(Direct)
(Direct)
SP2
M04526_2.00
Homo sapiens
NTWAGYCCCGCCCMCTT
AAGKGGGCGGGRCTWAN
SELEX
Yin et al.(2017)
SP2_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
SP2
M07932_2.00
Homo sapiens
KSCTAGAGMGGCBVB
VBVGCCKCTCTAGSM
ChIP-seq
Gerstein et al.(2012)
K562_SP2_HudsonAlpha
(Direct)
(Direct)
SP2
M08092_2.00
Homo sapiens
BYCCCGCCYCYBNNB
VNNVRGRGGCGGGRV
ChIP-seq
Mathelier et al.(2014)
MA0516.1
(Direct)
(Direct)
SP2
M08326_2.00
Homo sapiens
YCCCGCCCM
KGGGCGGGR
ChIP-seq
Schmitges et al.(2016)
Q02086_1-3.RCADE
(Direct)
(Direct)
SP2
M08911_2.00
Homo sapiens
SBBSNVSBCCCGCCYCYBBBBS
SVVVVRGRGGCGGGVSBNSVVS
Misc
Kulakovskiy et al.(2013)
SP2_HUMAN.H11MO.0.A
(Direct)
(Direct)
SP2
M10250_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_01
(Direct)
(Direct)
SP2
M10251_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_04
(Direct)
(Direct)
SP2
M10252_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_06
(Direct)
(Direct)
SP2
M10253_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_Q3_01
(Direct)
(Direct)
SP2
M10254_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SP2_Q3
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Sp2
M08970_2.00
Mus musculus
SBBSNVSBCCCGCCYCYBBBBS
SVVVVRGRGGCGGGVSBNSVVS
Misc
Kulakovskiy et al.(2013)
SP2_MOUSE.H11MO.0.B
0.827
1.000
For this family, TFs with SR scores >
0.755
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000365931
C2H2 ZF
525
549
HVCHIPDCGKTFRKTSLLRAHVRLH
ENSP00000365931
C2H2 ZF
555
579
FVCNWFFCGKRFTRSDELQRHARTH
ENSP00000365931
C2H2 ZF
585
607
FECAQCQKRFMRSDHLTKHYKTH
Links
Other
C2H2 ZF
family TFs
Other
Homo sapiens
TFs
55 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy