Sp4 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000025323 T101053_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within regulation of heart contraction. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP4 (Sp4 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Sp4
M00133_2.00		 Mus musculus
HMCGCCCMYN
NRKGGGCGKD		 PBM
Badis et al.(2009)
Sp4_1011		 (Direct) (Direct)
Sp4
M01862_2.00		 Mus musculus
NMCGCCCMY
RKGGGCGKN		 PBM
Weirauch et al.(2014)
pTH4998		 (Direct) (Direct)
Sp4
M05859_2.00		 Mus musculus
DGNYMCGCCCHNN
NNDGGGCGKRNCH		 SMiLE-seq
Isakova et al.(2017)
SP4		 (Direct) (Direct)
Sp4
M08975_2.00		 Mus musculus
BYHDKCYCCGCCYYYHBSBB
VVSVDRRRGGCGGRGMHDRV		 Misc
Kulakovskiy et al.(2013)
SP4_MOUSE.H11MO.0.B		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
SP4
M02879_2.00 		Homo sapiens
NWRGCCACGCCCMCHYN
NRDGKGGGCGTGGCYWN		 SELEX
Jolma et al.(2013)
SP4_1 		0.811 0.986
SP4
M08296_2.00 		Homo sapiens
NNVGCYCCKCCYMYH
DRKRGGMGGRGCBNN		 ChIP-seq
Schmitges et al.(2016)
Q02446.MEME 		0.811 0.986
SP4
M08873_2.00 		Homo sapiens
BYHDKCYCCGCCYYYHBSBB
VVSVDRRRGGCGGRGMHDRV		 Misc
Kulakovskiy et al.(2013)
SP4_HUMAN.H11MO.0.A 		0.811 0.986
SP4
M10165_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP4_Q3 		0.811 0.986
SP4
M10166_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP4_Q5 		0.811 0.986
Sp3
M08978_2.00 		Mus musculus
NBBNVSCCCCKCCCMBBBNN
NNVVVKGGGMGGGGSBNVVN		 Misc
Kulakovskiy et al.(2013)
SP3_MOUSE.H11MO.0.B 		0.782 0.942
Sp1
M00765_2.00 		Mus musculus
NMCGCCCMY
RKGGGCGKN		 PBM
Weirauch et al.(2013)
pTH0978 		0.775 0.899
Sp1
M08963_2.00 		Mus musculus
CCCBKCYCCKCCCCCNBCYCSBSC
GSVSGRGVNGGGGGMGGRGMVGGG		 Misc
Kulakovskiy et al.(2013)
SP1_MOUSE.H11MO.0.A 		0.775 0.899
Spps
M06159_2.00 		Drosophila melanogaster
KWDRCCMCGCCCMBH
DVKGGGCGKGGYHWM		 B1H
Zhu et al.(2011)
CG5669_SANGER_10_FBgn0039169 		0.772 0.870
Spps
M06160_2.00 		Drosophila melanogaster
BDDGCCMCGCCCMYN
NRKGGGCGKGGCHHV		 B1H
Zhu et al.(2011)
CG5669_SOLEXA_5_FBgn0039169 		0.772 0.870
SP1
M02921_2.00 		Homo sapiens
RCCMCDCCCMH
DKGGGHGKGGY		 SELEX
Jolma et al.(2013)
SP1_1 		0.772 0.884
SP1
M04605_2.00 		Homo sapiens
NWRRCCACGCCCMCH
DGKGGGCGTGGYYWN		 SELEX
Yin et al.(2017)
SP1_eDBD_HT-SELEX 		0.772 0.884
SP1
M08096_2.00 		Homo sapiens
BYCCCKCCCCY
RGGGGMGGGRV		 ChIP-seq
Mathelier et al.(2014)
MA0079.3 		0.772 0.884
SP1
M08363_2.00 		Homo sapiens
CCCHNBCYCCDCCCY
RGGGHGGRGVNDGGG		 ChIP-seq
Schmitges et al.(2016)
P08047.MEME 		0.772 0.884
SP1
M08938_2.00 		Homo sapiens
BCSSSBCCHVGCCCCGCCCCYN
NRGGGGCGGGGCBDGGVSSSGV		 Misc
Kulakovskiy et al.(2013)
SP1_HUMAN.H11MO.0.A 		0.772 0.884
SP1
M10294_2.00 		Homo sapiens
DSCMHGCCYH
DRGGCDKGSH		 Transfac
Matys et al.(2006)
V$SP1_01 		0.772 0.884
SP1
M10295_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_02 		0.772 0.884
SP1
M10296_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_07 		0.772 0.884
SP1
M10297_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_08 		0.772 0.884
SP1
M10298_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_Q2_02 		0.772 0.884
SP1
M10299_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP1_Q3 		0.772 0.884
SP1
M10300_2.00 		Homo sapiens
VVCCCCGCCCMBN
NVKGGGCGGGGBB		 Transfac
Matys et al.(2006)
V$SP1_Q6 		0.772 0.884
SP1
M04606_2.00 		Homo sapiens
NWRGCCMCGCCCMYH
DRKGGGCGKGGCYWN		 SELEX
Yin et al.(2017)
SP1_eDBD_Methyl-HT-SELEX 		0.772 0.884
Sp5
M09016_2.00 		Mus musculus
CYCCKCCYHYHBCYYHBYYYHYHB
VDRDRRRVDRRGVDRDRGGMGGRG		 Misc
Kulakovskiy et al.(2013)
SP5_MOUSE.H11MO.0.C 		0.769 0.899
SP5
M10319_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP5_Q2 		0.769 0.899
SP3
M02910_2.00 		Homo sapiens
VCCMCRCCCMY
RKGGGYGKGGB		 SELEX
Jolma et al.(2013)
SP3_1 		0.762 0.913
SP3
M04558_2.00 		Homo sapiens
NRCCACGCCCMYH
DRKGGGCGTGGYN		 SELEX
Yin et al.(2017)
SP3_eDBD_HT-SELEX 		0.762 0.913
SP3
M08920_2.00 		Homo sapiens
NBBNVSCCCCKCCCMBBBNN
NNVVVKGGGMGGGGSBNVVN		 Misc
Kulakovskiy et al.(2013)
SP3_HUMAN.H11MO.0.B 		0.762 0.913
SP3
M10263_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP3_Q3_01 		0.762 0.913
SP3
M10264_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$SP3_Q3 		0.762 0.913
SP3
M04559_2.00 		Homo sapiens
NRCCMCGCCCMCH
DGKGGGCGKGGYN		 SELEX
Yin et al.(2017)
SP3_eDBD_Methyl-HT-SELEX 		0.762 0.913
SP8
M02898_2.00 		Homo sapiens
VMCACBCCCMCH
DGKGGGVGTGKB		 SELEX
Jolma et al.(2013)
SP8_1 		0.762 0.899
SP8
M04517_2.00 		Homo sapiens
NMCMCGCCCMYH
DRKGGGCGKGKN		 SELEX
Yin et al.(2017)
SP8_eDBD_HT-SELEX 		0.762 0.899
SP8
M04518_2.00 		Homo sapiens
RHCACGCCCMYH
DRKGGGCGTGDY		 SELEX
Yin et al.(2017)
SP8_eDBD_Methyl-HT-SELEX 		0.762 0.899
SP9
M04645_2.00 		Homo sapiens
VMCMCGCCCMYH
DRKGGGCGKGKB		 SELEX
Yin et al.(2017)
SP9_eDBD_HT-SELEX 		0.762 0.884
SP9
M04646_2.00 		Homo sapiens
RYCACGCCCMYH
DRKGGGCGTGRY		 SELEX
Yin et al.(2017)
SP9_eDBD_Methyl-HT-SELEX 		0.762 0.884
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00133_2.00 C2H2 ZF 16 40
M00133_2.00 C2H2 ZF 46 70
M00133_2.00 C2H2 ZF 76 98
M01862_2.00 C2H2 ZF 1 25
M01862_2.00 C2H2 ZF 31 55
M01862_2.00 C2H2 ZF 61 83

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000026367 C2H2 ZF 645 669
ENSMUSP00000026367 C2H2 ZF 675 699
ENSMUSP00000026367 C2H2 ZF 705 727

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

422 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action