Hic1 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000043099 T101179_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; immune system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Hic1
M00141_2.00		 Mus musculus
RTGCCMNBN
NVNKGGCAY		 PBM
Badis et al.(2009)
Hic1_2816		 (Direct) (Direct)
Hic1
M02933_2.00		 Mus musculus
RTGCCAVCYBRTGCCAVC
GBTGGCAYVRGBTGGCAY		 SELEX
Jolma et al.(2013)
Hic1_1		 (Direct) (Direct)
Hic1
M02934_2.00		 Mus musculus
RTGCCAVCN
NGBTGGCAY		 SELEX
Jolma et al.(2013)
Hic1_2		 (Direct) (Direct)
Hic1
M09003_2.00		 Mus musculus
KGGCAMCCH
DGGKTGCCM		 Misc
Kulakovskiy et al.(2013)
HIC1_MOUSE.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HIC2
M02902_2.00 		Homo sapiens
RTGCCMVNN
NNBKGGCAY		 SELEX
Jolma et al.(2013)
HIC2_1 		0.795 0.852
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00141_2.00 C2H2 ZF 16 38
M00141_2.00 C2H2 ZF 86 108
M00141_2.00 C2H2 ZF 114 136
M00141_2.00 C2H2 ZF 142 164
M00141_2.00 C2H2 ZF 170 192

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000053483 C2H2 ZF 597 619
ENSMUSP00000053483 C2H2 ZF 667 689
ENSMUSP00000053483 C2H2 ZF 695 717
ENSMUSP00000053483 C2H2 ZF 723 745
ENSMUSP00000053483 C2H2 ZF 751 773

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

Invalid Input OrderBy

63 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action