Zbtb14 (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000049672 T101252_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within heart development and kidney development. Predicted to be located in aggresome; cytosol; and nucleolus. Predicted to be active in nucleoplasm. Is expressed in ureter. Orthologous to human ZBTB14 (zinc finger and BTB domain containing 14). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zbtb14
M00145_2.00		 Mus musculus
NNCGHGNNN
NNNCDCGNN		 PBM
Badis et al.(2009)
Zfp161_2858		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZBTB14
M04629_2.00 		Homo sapiens
DYGCGCGTGCACGHBN
NVDCGTGCACGCGCRH		 SELEX
Yin et al.(2017)
ZBTB14_eDBD_HT-SELEX 		0.827 1.000
ZBTB14
M04631_2.00 		Homo sapiens
HCRCGTGCACGCGCAY
RTGCGCGTGCACGYGD		 SELEX
Yin et al.(2017)
ZBTB14_FL_HT-SELEX 		0.827 1.000
ZBTB14
M08387_2.00 		Homo sapiens
SCGCGCSCS
SGSGCGCGS		 ChIP-seq
Schmitges et al.(2016)
O43829_2-4.RCADE 		0.827 1.000
ZBTB14
M08954_2.00 		Homo sapiens
GCGCGCWCN
NGWGCGCGC		 Misc
Kulakovskiy et al.(2013)
ZBT14_HUMAN.H11MO.0.C 		0.827 1.000
ZBTB14
M10316_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZF5_01 		0.827 1.000
ZBTB14
M10317_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZF5_B 		0.827 1.000
ZBTB14
M04630_2.00 		Homo sapiens
VYGCGCGYGCACGYNN
NNRCGTGCRCGCGCRB		 SELEX
Yin et al.(2017)
ZBTB14_eDBD_Methyl-HT-SELEX 		0.827 1.000
ZBTB14
M04632_2.00 		Homo sapiens
TCACGTGCACGCGCAC
GTGCGCGTGCACGTGA		 SELEX
Yin et al.(2017)
ZBTB14_FL_Methyl-HT-SELEX 		0.827 1.000
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00145_2.00 C2H2 ZF 16 38
M00145_2.00 C2H2 ZF 44 66
M00145_2.00 C2H2 ZF 72 94
M00145_2.00 C2H2 ZF 100 122
M00145_2.00 C2H2 ZF 128 151

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000054897 C2H2 ZF 277 299
ENSMUSP00000054897 C2H2 ZF 305 327
ENSMUSP00000054897 C2H2 ZF 333 355
ENSMUSP00000054897 C2H2 ZF 361 383
ENSMUSP00000054897 C2H2 ZF 389 412
ENSMUSP00000108294 C2H2 ZF 277 299
ENSMUSP00000108294 C2H2 ZF 305 327
ENSMUSP00000108294 C2H2 ZF 333 355
ENSMUSP00000108294 C2H2 ZF 361 383
ENSMUSP00000108294 C2H2 ZF 389 412
ENSMUSP00000108296 C2H2 ZF 277 299
ENSMUSP00000108296 C2H2 ZF 305 327
ENSMUSP00000108296 C2H2 ZF 333 355
ENSMUSP00000108296 C2H2 ZF 361 383
ENSMUSP00000108296 C2H2 ZF 389 412

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

46 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000003128 Papio anubis ENSPANG00000003128 I 0.827
ZBTB14 Procavia capensis ENSPCAG00000008601 I 0.827
ZBTB14 Otolemur garnettii ENSOGAG00000009683 I 0.827
ZBTB14 Oryctolagus cuniculus ENSOCUG00000004131 I 0.827
ENSMPUG00000004990 Mustela putorius furo ENSMPUG00000004990 I 0.827
ENSNLEG00000006918 Nomascus leucogenys ENSNLEG00000006918 I 0.827
ENSPPYG00000009025 Pongo abelii ENSPPYG00000009025 I 0.827
ZBTB14 Pan troglodytes ENSPTRG00000029352 I 0.827
ENSP00000349503-D1 Bos grunniens ENSP00000349503-D1 I 0.827
ENSP00000349503 Macaca fascicularis ENSP00000349503 I 0.827
ZBTB14 Tupaia belangeri ENSTBEG00000017107 I 0.827
ENSSTOG00000010216 Ictidomys tridecemlineatus ENSSTOG00000010216 I 0.827
ZBTB14 Pteropus vampyrus ENSPVAG00000012683 I 0.827
Zfp161 Rattus norvegicus ENSRNOG00000016719 I 0.827
ZBTB14 Macaca mulatta ENSMMUG00000022005 I 0.827
ZBTB14 Choloepus hoffmanni ENSCHOG00000012883 I 0.827
ZBTB14 Felis catus ENSFCAG00000023573 I 0.827
ZBTB14 Echinops telfairi ENSETEG00000004337 I 0.827
ZBTB14 Equus caballus ENSECAG00000019218 I 0.827
ZBTB14 Callithrix jacchus ENSCJAG00000037461 I 0.827
ENSDORG00000015193 Dipodomys ordii ENSDORG00000015193 I 0.827
ZBTB14 Canis familiaris ENSCAFG00000018554 I 0.827
ZBTB14 Homo sapiens ENSG00000198081 D 0.827
ZBTB14 Gorilla gorilla ENSGGOG00000024397 I 0.827
ENSCSAG00000017588 Chlorocebus sabaeus ENSCSAG00000017588 I 0.827
ENSAMEG00000020014 Ailuropoda melanoleuca ENSAMEG00000020014 I 0.827
ZBTB14 Bos taurus ENSBTAG00000038970 I 0.827
Pvit_14008 Pogona vitticeps Pvit_14008 I 0.779
Ogr15623 Ophisaurus gracilis Ogr15623 I 0.779
Alligator_sinensis_CCG006333.1 Alligator sinensis Alligator_sinensis_CCG006333.1 I 0.779
ENSPSIG00000005537 Pelodiscus sinensis ENSPSIG00000005537 I 0.779
ZBTB14 Anolis carolinensis ENSACAG00000009653 I 0.779
ZBTB14 Ornithorhynchus anatinus ENSOANG00000005381 I 0.779
ENSMEUG00000012751 Macropus eugenii ENSMEUG00000012751 I 0.779
ZBTB14 Monodelphis domestica ENSMODG00000021460 I 0.779
ENSGALG00000014771 Gallus gallus ENSGALG00000014771 I 0.771
ZBTB14 Meleagris gallopavo ENSMGAG00000015827 I 0.769
ENSFALG00000006322 Ficedula albicollis ENSFALG00000006322 I 0.769
Tal_R006431 Tyto alba Tal_R006431 I 0.769
Afo_R005854 Aptenodytes forsteri Afo_R005854 I 0.769
Gfo_R012109 Geospiza fortis Gfo_R012109 I 0.769
Aan_R005355 Calypte anna Aan_R005355 I 0.769
ENSAPLG00000011548 Anas platyrhynchos ENSAPLG00000011548 I 0.769
zbtb14 Xenopus tropicalis XB-GENE-968315 I 0.767
ENSLACG00000011224 Latimeria chalumnae ENSLACG00000011224 I 0.763