klu-1 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00013970 T131613_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in anal depressor muscle; body wall musculature; and reproductive system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Orthologous to human GLI4 (GLI family zinc finger 4) and IKZF1 (IKAROS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
klu-1
M00637_2.00		 Caenorhabditis elegans
CDCCCMCV
BGKGGGHG		 PBM
Narasimhan et al.(2015)
pTH9355		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00637_2.00 C2H2 ZF 51 74
M00637_2.00 C2H2 ZF 88 110
M00637_2.00 C2H2 ZF 116 138
M00637_2.00 C2H2 ZF 144 166

DNA Binding Domains

Protein ID Domain From To Sequence
ZK337.2 C2H2 ZF 332 355
ZK337.2 C2H2 ZF 369 391
ZK337.2 C2H2 ZF 397 419
ZK337.2 C2H2 ZF 425 447

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

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24 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action